A novel mechanism of cytokine release in phagocytes induced by aggretin, a snake venom C‐type lectin protein, through CLEC‐2 ligation

Summary Background: Macrophages are major immune cells and play an important role in modulating homeostasis and the immune defense mechanism. In inflammatory responses to the infection of pathogens, macrophages are activated, producing various inflammatory mediators. Snake venom C‐type lectin prote...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2010-11, Vol.8 (11), p.2563-2570
Hauptverfasser:	CHANG, C.‐H., CHUNG, C.‐H., HSU, C.‐C., HUANG, T.‐Y., HUANG, T.‐F.
Format:	Artikel
Sprache:	eng
Schlagworte:	aggretin Animals Cell activation CLEC‐2 Cytokines - metabolism Inflammation Interleukin-6 - metabolism Lectins, C-Type - chemistry Lectins, C-Type - metabolism Macrophages - cytology MAP Kinase Signaling System Mice Mice, Inbred ICR Monocytes - cytology NF-kappa B - metabolism Phagocytes - cytology snake venom C‐type lectin proteins Snake Venoms Tumor Necrosis Factor-alpha - metabolism Viper Venoms - metabolism
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