HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF

Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks of malignancy, but their molecular basis and interrelationship remains enigmatic. We report that the host-produced histidine-rich glycoprotei...

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Veröffentlicht in:	Cancer cell 2011-01, Vol.19 (1), p.31-44
Hauptverfasser:	Rolny, Charlotte, Mazzone, Massimiliano, Tugues, Sònia, Laoui, Damya, Johansson, Irja, Coulon, Cathy, Squadrito, Mario Leonardo, Segura, Inmaculada, Li, Xiujuan, Knevels, Ellen, Costa, Sandra, Vinckier, Stefan, Dresselaer, Tom, Åkerud, Peter, De Mol, Maria, Salomäki, Henriikka, Phillipson, Mia, Wyns, Sabine, Larsson, Erik, Buysschaert, Ian, Botling, Johan, Himmelreich, Uwe, Van Ginderachter, Jo A., De Palma, Michele, Dewerchin, Mieke, Claesson-Welsh, Lena, Carmeliet, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - immunology Antibodies - pharmacology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell Line, Tumor Cell Proliferation - drug effects Chemotactic Factors - metabolism Clodronic Acid - pharmacology Culture Media, Conditioned - pharmacology Cytokines - metabolism Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - pathology Down-Regulation - genetics Endothelial Cells - cytology Endothelial Cells - drug effects Gene Expression - drug effects Gene Expression - genetics Humans Hypoxia - genetics Hypoxia - metabolism Lung Neoplasms - genetics Lung Neoplasms - immunology Lung Neoplasms - pathology Lung Neoplasms - secondary Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Macrophages - pathology Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Microvessels - drug effects Microvessels - pathology Microvessels - ultrastructure Neoplasm Metastasis - genetics Neoplasm Metastasis - immunology Neoplasm Metastasis - pathology Neoplasms - blood supply Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - immunology Neovascularization, Pathologic - pathology Placenta Growth Factor Pregnancy Proteins - genetics Pregnancy Proteins - immunology Pregnancy Proteins - metabolism Proteins - genetics Proteins - metabolism Proteins - pharmacology Regional Blood Flow - drug effects Regional Blood Flow - genetics Transfection
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