Differential regulation of MMP7 in colon cancer cells resistant and sensitive to oxaliplatin-induced cell death

Background: We have previously shown that metalloproteinase 7 (MMP7) expression is increased during the acquisition of resistance to oxaliplatin in colon cancer cells. Now we have analyzed the implication of β-catenin and EGFR pathways in the up-regulation of MMP7 in the oxaliplatin-resistant human...

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Veröffentlicht in:	Cancer biology & therapy 2011-01, Vol.11 (1), p.4-13
Hauptverfasser:	Ametller, Elisabet, García-Recio, Susana, Pastor-Arroyo, Eva-María, Callejo, Gerard, Carbó, Neus, Gascón, Pedro, Almendro, Vanessa
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology beta Catenin - antagonists & inhibitors beta Catenin - biosynthesis beta Catenin - genetics beta Catenin - metabolism Binding Biology Bioscience Calcium Cancer Cell Cell Line, Tumor Cell Nucleus - drug effects Cell Nucleus - metabolism Colonic Neoplasms - drug therapy Colonic Neoplasms - enzymology Colonic Neoplasms - genetics Cycle Drug Resistance, Neoplasm Enzyme Activation - drug effects ErbB Receptors - biosynthesis ErbB Receptors - genetics ErbB Receptors - metabolism HCT116 Cells HT29 Cells Humans Landes Matrix Metalloproteinase 7 - biosynthesis Matrix Metalloproteinase 7 - genetics Organogenesis Organoplatinum Compounds - pharmacology Oxaliplatin Proteins RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics Transcription Factors - metabolism Transfection Up-Regulation
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