Cells of origin in cancer
Both solid tumours and leukaemias show considerable histological and functional heterogeneity. It is widely accepted that genetic lesions have a major role in determining tumour phenotype, but evidence is also accumulating that cancers of distinct subtypes within an organ may derive from different &...
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| Veröffentlicht in: | Nature (London) 2011-01, Vol.469 (7330), p.314-322 |
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| creator | Visvader, Jane E. |
| description | Both solid tumours and leukaemias show considerable histological and functional heterogeneity. It is widely accepted that genetic lesions have a major role in determining tumour phenotype, but evidence is also accumulating that cancers of distinct subtypes within an organ may derive from different 'cells of origin'. These cells acquire the first genetic hit or hits that culminate in the initiation of cancer. The identification of these crucial target cell populations may allow earlier detection of malignancies and better prediction of tumour behaviour, and ultimately may lead to preventive therapies for individuals at high risk of developing cancer. |
| doi_str_mv | 10.1038/nature09781 |
| format | Article |
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| subjects | 631/67/71 692/700/139 692/700/565/1436/1983 Animals Biological and medical sciences Cancer Carcinogenesis, carcinogens and anticarcinogens Cell Lineage Cells Development and progression DNA repair Epigenetics General aspects Genetic aspects Genotype & phenotype Hematologic Neoplasms - pathology Heterogeneity Humanities and Social Sciences Humans Leukemia Medical sciences Models, Biological multidisciplinary Mutation Neoplasms - diagnosis Neoplasms - genetics Neoplasms - pathology Neoplasms - therapy Neoplastic Stem Cells - pathology Phenotype review-article Science Science (multidisciplinary) Tumors |
| title | Cells of origin in cancer |
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