Independence of Allotypic Determinants and Antibody Specificity
Studies were carried out to ascertain whether the specificity of an IgG antibody molecule influences the expression of the full complement of determinants characteristic of a given allotype. The presence of determinants was measured by the capacity of a given IgG preparation to displace from anti-al...
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| Veröffentlicht in: | The Journal of immunology (1950) 1970-09, Vol.105 (3), p.653-660 |
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| container_end_page | 660 |
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| container_issue | 3 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 105 |
| creator | Spring, Susan B Nisonoff, Alfred Dray, Sheldon |
| description | Studies were carried out to ascertain whether the specificity of an IgG antibody molecule influences the expression of the full complement of determinants characteristic of a given allotype. The presence of determinants was measured by the capacity of a given IgG preparation to displace from anti-allotypic antibodies all of a reference 125I-Fab fragment, possessing the same allotype, but derived from a different source. The results indicated that all IgG molecules studied, including specifically purified antibodies, possess a full complement of determinants (a1, a3, b4) and suggest that the portion of the surface of the molecule comprising the antibody-combining site is independent of the region of the surface which combines with anti-allotypic antibodies. |
| doi_str_mv | 10.4049/jimmunol.105.3.653 |
| format | Article |
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The results indicated that all IgG molecules studied, including specifically purified antibodies, possess a full complement of determinants (a1, a3, b4) and suggest that the portion of the surface of the molecule comprising the antibody-combining site is independent of the region of the surface which combines with anti-allotypic antibodies.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.105.3.653</identifier><identifier>PMID: 4195497</identifier><language>eng</language><publisher>United States: Am Assoc Immnol</publisher><subject>Animals ; Antibodies ; Antibody Specificity ; Antigen-Antibody Reactions ; Antigens ; Azo Compounds ; Benzoates ; Binding Sites ; Chromatography, DEAE-Cellulose ; Dinitrophenols ; Epitopes ; Immune Sera ; Immunochemistry ; Immunoelectrophoresis ; Immunoglobulin G ; Iodine Isotopes ; Molecular Biology ; Rabbits</subject><ispartof>The Journal of immunology (1950), 1970-09, Vol.105 (3), p.653-660</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-a3bcf49f3199a37b444a6250735798954d4bbe56bbc75fac02293f7c0363821d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4195497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spring, Susan B</creatorcontrib><creatorcontrib>Nisonoff, Alfred</creatorcontrib><creatorcontrib>Dray, Sheldon</creatorcontrib><title>Independence of Allotypic Determinants and Antibody Specificity</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>Studies were carried out to ascertain whether the specificity of an IgG antibody molecule influences the expression of the full complement of determinants characteristic of a given allotype. 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| ispartof | The Journal of immunology (1950), 1970-09, Vol.105 (3), p.653-660 |
| issn | 0022-1767 1550-6606 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84689180 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antibodies Antibody Specificity Antigen-Antibody Reactions Antigens Azo Compounds Benzoates Binding Sites Chromatography, DEAE-Cellulose Dinitrophenols Epitopes Immune Sera Immunochemistry Immunoelectrophoresis Immunoglobulin G Iodine Isotopes Molecular Biology Rabbits |
| title | Independence of Allotypic Determinants and Antibody Specificity |
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