The Dynamics of Life, II. The Steady-State Theory of Mutation Rates
The statistical effect of internal irradiation on the survival of beagles is similar to that of aging, with the exception that death occurs earlier. Since biological processes are close to equilibrium most of the time, the above observation suggests that death ensues when the rate of insult has exce...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1970-06, Vol.66 (2), p.441-444 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 66 |
| creator | Eyring, Henry Stover, Betsy J. |
| description | The statistical effect of internal irradiation on the survival of beagles is similar to that of aging, with the exception that death occurs earlier. Since biological processes are close to equilibrium most of the time, the above observation suggests that death ensues when the rate of insult has exceeded the rate of recovery to a sufficient extent that the reserves are depleted and the steady state can no longer be maintained. The steady-state theory of mutation rates is derived from first principles, and, through absolute rate theory, is completely general and is not limited to a specific kind of cellular alteration. However, the nature of the cellular alterations that lead to nonsurvival are considered. The young growing system is also considered in the context of this theory. |
| doi_str_mv | 10.1073/pnas.66.2.441 |
| format | Article |
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The steady-state theory of mutation rates is derived from first principles, and, through absolute rate theory, is completely general and is not limited to a specific kind of cellular alteration. However, the nature of the cellular alterations that lead to nonsurvival are considered. 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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1970-06, Vol.66 (2), p.441-444 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Age Aging Biochemistry Biological Evolution Biological Sciences: Biochemistry Cell growth Genes Genetic mutation Genetics Irradiation Lead Mathematics Models, Theoretical Mutation Neoplasms - genetics Poisons Steady state theory Stover |
| title | The Dynamics of Life, II. The Steady-State Theory of Mutation Rates |
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