Syntheses of Aminoalkylguanidine Derivatives

Syntheses of Aminoalkylguanidine Derivatives

The hydrochlorides of N1-benzyl-2-methyl-1, 2-propanediamine (I) and 5-amino-1, 3-dibenzyl-5-methylhexahydropyrimidine (II) were debenzylated by the catalytic hydrogenation under pressure. 2-Methyl-1, 2-propanediamine (III) which obtained from I, was derived to monoguanidine compound. The structure...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1967/07/25, Vol.15(7), pp.936-943
Hauptverfasser: Tsuji, Tadakazu, Momona, Hiroko, Ueda, Takeo
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Sprache:eng
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Amines
Guanidines - chemical synthesis
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container_end_page 943
container_issue 7
container_start_page 936
container_title Chemical & pharmaceutical bulletin
container_volume 15
creator Tsuji, Tadakazu
Momona, Hiroko
Ueda, Takeo
description The hydrochlorides of N1-benzyl-2-methyl-1, 2-propanediamine (I) and 5-amino-1, 3-dibenzyl-5-methylhexahydropyrimidine (II) were debenzylated by the catalytic hydrogenation under pressure. 2-Methyl-1, 2-propanediamine (III) which obtained from I, was derived to monoguanidine compound. The structure of this compound was concluded to be (2-amino-2-methylpropyl) guanidine from the comparison of the infrared spectra of related compounds. 2-Methyl-1, 2, 3-propanetriamine obtained from II, its starting material II, and other ethylenediamine derivatives were also guanidilated by the action of S-methylisothiourea sulfate.
doi_str_mv 10.1248/cpb.15.936
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subjects Amines
Guanidines - chemical synthesis
title Syntheses of Aminoalkylguanidine Derivatives
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