Effect of glycine loading on plasma and urinary uric acid and amino acids in normal and gouty subjects

A single oral dose of glycine, 100 mg/kg body weight, a “physiologic” load, was given to ten normal men and seventeen patients with primary gout. The ensuing uricosuria, chiefly due to increased renal clearance of uric acid, was relatively greater in the gouty subjects. That the uricosuria was not d...

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