Determination of Deoxyribonucleic Acid Content of Heart Muscle in Experimental Cardiac Hypertrophy
Total DNA content of the whole heart muscle of the Goldblatt rats was chemically determined, and the DNA content per single nucleus of the heart muscle cell and of the interstitial cell was determined by the microspectrophotometric method, in order to substantiate the assumption of cell division of...
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| Veröffentlicht in: | The Tohoku Journal of Experimental Medicine 1970, Vol.101(2), pp.153-159 |
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| container_title | The Tohoku Journal of Experimental Medicine |
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| creator | SASAKI, RIKURO MORISHITA, TOSHIAKI YAMAGATA, SHOICHI |
| description | Total DNA content of the whole heart muscle of the Goldblatt rats was chemically determined, and the DNA content per single nucleus of the heart muscle cell and of the interstitial cell was determined by the microspectrophotometric method, in order to substantiate the assumption of cell division of the heart muscle in experimental cardiac hypertrophy. Total DNA content of the whole heart muscle and the DNA content per 100mg of heart weight in the hypertensive group was significantly higher than those in the control group. The DNA content per nucleus of the muscle cell and of interstitial cell was found to be constant in both groups. It seems that the increase in DNA content indicates the increase in the number of heart muscle cells as well as of interstitial cells. |
| doi_str_mv | 10.1620/tjem.101.153 |
| format | Article |
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Total DNA content of the whole heart muscle and the DNA content per 100mg of heart weight in the hypertensive group was significantly higher than those in the control group. The DNA content per nucleus of the muscle cell and of interstitial cell was found to be constant in both groups. 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Exp. Med.</addtitle><description>Total DNA content of the whole heart muscle of the Goldblatt rats was chemically determined, and the DNA content per single nucleus of the heart muscle cell and of the interstitial cell was determined by the microspectrophotometric method, in order to substantiate the assumption of cell division of the heart muscle in experimental cardiac hypertrophy. Total DNA content of the whole heart muscle and the DNA content per 100mg of heart weight in the hypertensive group was significantly higher than those in the control group. The DNA content per nucleus of the muscle cell and of interstitial cell was found to be constant in both groups. It seems that the increase in DNA content indicates the increase in the number of heart muscle cells as well as of interstitial cells.</description><subject>Animals</subject><subject>Body Weight</subject><subject>Cardiomegaly - metabolism</subject><subject>deoxyribonucleic acid</subject><subject>DNA - analysis</subject><subject>experimental cardiac hvnertrophy</subject><subject>heart muscle</subject><subject>Hypertension - metabolism</subject><subject>Hypertrophy - metabolism</subject><subject>Myocardium - analysis</subject><subject>Organ Size</subject><subject>Rats</subject><issn>0040-8727</issn><issn>1349-3329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAURi0EgvLYWJE8MZHiV2JnROVRJBAD7JHt3oCrJC62I9F_j0tLF1v2d-6nq4PQJSVTWjFym5bQTymhU1ryAzShXNQF56w-RBNCBCmUZPIEnca4JIQLIqtjdCyYkFUlJ8jcQ4LQu0En5wfsW3wP_mcdnPHDaDtwFt9Zt8AzPyQY0gaYgw4Jv44xx9gN-OFnBcH1OdUdnumwcNri-Tp_puBXX-tzdNTqLsLF7j5D748PH7N58fL29Dy7eylsWYpUGMtY1YI1tagMK5VtqdVcaqm0Va1hkirGRFVKo5Rhi5pwVXImoOS6tYyfoett6yr47xFianoXLXSdHsCPsVF5lBNCM3izBW3wMQZom1XeXod1Q0mzEdpshOYHbbLQjF_tekfTw2IP7wzm_HGbL2PSn7DPsyOXBf2V0Tq3bgrZ_1nyPWC_dGhg4L-5c4ss</recordid><startdate>19700101</startdate><enddate>19700101</enddate><creator>SASAKI, RIKURO</creator><creator>MORISHITA, TOSHIAKI</creator><creator>YAMAGATA, SHOICHI</creator><general>Tohoku University Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19700101</creationdate><title>Determination of Deoxyribonucleic Acid Content of Heart Muscle in Experimental Cardiac Hypertrophy</title><author>SASAKI, RIKURO ; MORISHITA, TOSHIAKI ; YAMAGATA, SHOICHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-bc226fecb946b258cf1ca37a78ac8fb2718224657b88b2d90385324e53afc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Animals</topic><topic>Body Weight</topic><topic>Cardiomegaly - metabolism</topic><topic>deoxyribonucleic acid</topic><topic>DNA - analysis</topic><topic>experimental cardiac hvnertrophy</topic><topic>heart muscle</topic><topic>Hypertension - metabolism</topic><topic>Hypertrophy - metabolism</topic><topic>Myocardium - analysis</topic><topic>Organ Size</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SASAKI, RIKURO</creatorcontrib><creatorcontrib>MORISHITA, TOSHIAKI</creatorcontrib><creatorcontrib>YAMAGATA, SHOICHI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Tohoku Journal of Experimental Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SASAKI, RIKURO</au><au>MORISHITA, TOSHIAKI</au><au>YAMAGATA, SHOICHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of Deoxyribonucleic Acid Content of Heart Muscle in Experimental Cardiac Hypertrophy</atitle><jtitle>The Tohoku Journal of Experimental Medicine</jtitle><addtitle>Tohoku J. Exp. Med.</addtitle><date>1970-01-01</date><risdate>1970</risdate><volume>101</volume><issue>2</issue><spage>153</spage><epage>159</epage><pages>153-159</pages><issn>0040-8727</issn><eissn>1349-3329</eissn><abstract>Total DNA content of the whole heart muscle of the Goldblatt rats was chemically determined, and the DNA content per single nucleus of the heart muscle cell and of the interstitial cell was determined by the microspectrophotometric method, in order to substantiate the assumption of cell division of the heart muscle in experimental cardiac hypertrophy. Total DNA content of the whole heart muscle and the DNA content per 100mg of heart weight in the hypertensive group was significantly higher than those in the control group. The DNA content per nucleus of the muscle cell and of interstitial cell was found to be constant in both groups. It seems that the increase in DNA content indicates the increase in the number of heart muscle cells as well as of interstitial cells.</abstract><cop>Japan</cop><pub>Tohoku University Medical Press</pub><pmid>4247667</pmid><doi>10.1620/tjem.101.153</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Body Weight Cardiomegaly - metabolism deoxyribonucleic acid DNA - analysis experimental cardiac hvnertrophy heart muscle Hypertension - metabolism Hypertrophy - metabolism Myocardium - analysis Organ Size Rats |
| title | Determination of Deoxyribonucleic Acid Content of Heart Muscle in Experimental Cardiac Hypertrophy |
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