Oxidative metabolism of the brain in the experimental cerebral edema
The interrelation of the cerebral water content on the activity of some cerebral enzymes was studied in dogs with experimental edema of the brain. NAD-specific isocitric dehydrogenase, glutamyl transferase and acid phosphatase activity were found to be increased in the edematous cerebral tissue, whi...
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| Veröffentlicht in: | Experimental neurology 1967-12, Vol.19 (4), p.455-462 |
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| container_end_page | 462 |
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| container_issue | 4 |
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| container_title | Experimental neurology |
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| creator | Păuşescu, E. Schwartz, B. Chirvasie, R. Dincă, A. |
| description | The interrelation of the cerebral water content on the activity of some cerebral enzymes was studied in dogs with experimental edema of the brain. NAD-specific isocitric dehydrogenase, glutamyl transferase and acid phosphatase activity were found to be increased in the edematous cerebral tissue, while succinic dehydrogenase, α-ketoglutaric dehydrogenase and alkaline phosphatase activity were unmodified; 2,4-dinitrophenol did not induce depression of the ability of edematous cerebral tissue to oxidize isocitrate, α-ketoglutarate and succinate. These observations suggest that the effect of cerebral edema may be related to decreased high-energy phosphate metabolism with subsequent alteration of oxidative phosphorilation of some substrates. |
| doi_str_mv | 10.1016/0014-4886(67)90165-3 |
| format | Article |
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NAD-specific isocitric dehydrogenase, glutamyl transferase and acid phosphatase activity were found to be increased in the edematous cerebral tissue, while succinic dehydrogenase, α-ketoglutaric dehydrogenase and alkaline phosphatase activity were unmodified; 2,4-dinitrophenol did not induce depression of the ability of edematous cerebral tissue to oxidize isocitrate, α-ketoglutarate and succinate. These observations suggest that the effect of cerebral edema may be related to decreased high-energy phosphate metabolism with subsequent alteration of oxidative phosphorilation of some substrates.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1016/0014-4886(67)90165-3</identifier><identifier>PMID: 6078168</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acid Phosphatase - metabolism ; Alkaline Phosphatase - metabolism ; Animals ; Brain - metabolism ; Brain Edema - enzymology ; Brain Edema - metabolism ; Dinitrophenols - pharmacology ; Dogs ; Isocitrate Dehydrogenase - metabolism ; Oxidative Phosphorylation - drug effects ; Oxidoreductases - metabolism ; Succinate Dehydrogenase - metabolism ; Transaminases - metabolism ; Water - analysis</subject><ispartof>Experimental neurology, 1967-12, Vol.19 (4), p.455-462</ispartof><rights>1967</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-3860c513018742557e775b7330e508d23853a42325db7701707c0e381df1db0e3</citedby><cites>FETCH-LOGICAL-c357t-3860c513018742557e775b7330e508d23853a42325db7701707c0e381df1db0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-4886(67)90165-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6078168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Păuşescu, E.</creatorcontrib><creatorcontrib>Schwartz, B.</creatorcontrib><creatorcontrib>Chirvasie, R.</creatorcontrib><creatorcontrib>Dincă, A.</creatorcontrib><title>Oxidative metabolism of the brain in the experimental cerebral edema</title><title>Experimental neurology</title><addtitle>Exp Neurol</addtitle><description>The interrelation of the cerebral water content on the activity of some cerebral enzymes was studied in dogs with experimental edema of the brain. NAD-specific isocitric dehydrogenase, glutamyl transferase and acid phosphatase activity were found to be increased in the edematous cerebral tissue, while succinic dehydrogenase, α-ketoglutaric dehydrogenase and alkaline phosphatase activity were unmodified; 2,4-dinitrophenol did not induce depression of the ability of edematous cerebral tissue to oxidize isocitrate, α-ketoglutarate and succinate. These observations suggest that the effect of cerebral edema may be related to decreased high-energy phosphate metabolism with subsequent alteration of oxidative phosphorilation of some substrates.</description><subject>Acid Phosphatase - metabolism</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Brain - metabolism</subject><subject>Brain Edema - enzymology</subject><subject>Brain Edema - metabolism</subject><subject>Dinitrophenols - pharmacology</subject><subject>Dogs</subject><subject>Isocitrate Dehydrogenase - metabolism</subject><subject>Oxidative Phosphorylation - drug effects</subject><subject>Oxidoreductases - metabolism</subject><subject>Succinate Dehydrogenase - metabolism</subject><subject>Transaminases - metabolism</subject><subject>Water - analysis</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gcKeRA-rk02ySS-C1E8o9KLnkE1mMbLbrcm21H9v1haPwkAm874zmTyEnFO4oUDLWwDKc65UeVXK62mqiJwdkDGFKeQFZ3BIxn-WY3IS4ycATHkhR2RUglS0VGPysNh6Z3q_wazF3lRd42ObdXXWf2BWBeOXWYrhgtsVBt_isjdNZjFgUpsMHbbmlBzVpol4tj8n5P3p8W32ks8Xz6-z-3lumZB9zlQJVlAGVEleCCFRSlFJxgAFKFcwJZjhBSuEq6QEKkFaQKaoq6mrUjYhl7u5q9B9rTH2uvXRYtOYJXbrqBUveTGVKhn5zmhDF2PAWq_S6iZ8awp6gKcHMnogo0upf-Fpltou9vPXVYvur2lPK-l3Ox3TJzceg47W49Ki8wFtr13n_3_gB1KPe-I</recordid><startdate>196712</startdate><enddate>196712</enddate><creator>Păuşescu, E.</creator><creator>Schwartz, B.</creator><creator>Chirvasie, R.</creator><creator>Dincă, A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196712</creationdate><title>Oxidative metabolism of the brain in the experimental cerebral edema</title><author>Păuşescu, E. ; Schwartz, B. ; Chirvasie, R. ; Dincă, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-3860c513018742557e775b7330e508d23853a42325db7701707c0e381df1db0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Acid Phosphatase - metabolism</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>Brain - metabolism</topic><topic>Brain Edema - enzymology</topic><topic>Brain Edema - metabolism</topic><topic>Dinitrophenols - pharmacology</topic><topic>Dogs</topic><topic>Isocitrate Dehydrogenase - metabolism</topic><topic>Oxidative Phosphorylation - drug effects</topic><topic>Oxidoreductases - metabolism</topic><topic>Succinate Dehydrogenase - metabolism</topic><topic>Transaminases - metabolism</topic><topic>Water - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Păuşescu, E.</creatorcontrib><creatorcontrib>Schwartz, B.</creatorcontrib><creatorcontrib>Chirvasie, R.</creatorcontrib><creatorcontrib>Dincă, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Păuşescu, E.</au><au>Schwartz, B.</au><au>Chirvasie, R.</au><au>Dincă, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative metabolism of the brain in the experimental cerebral edema</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>1967-12</date><risdate>1967</risdate><volume>19</volume><issue>4</issue><spage>455</spage><epage>462</epage><pages>455-462</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><abstract>The interrelation of the cerebral water content on the activity of some cerebral enzymes was studied in dogs with experimental edema of the brain. NAD-specific isocitric dehydrogenase, glutamyl transferase and acid phosphatase activity were found to be increased in the edematous cerebral tissue, while succinic dehydrogenase, α-ketoglutaric dehydrogenase and alkaline phosphatase activity were unmodified; 2,4-dinitrophenol did not induce depression of the ability of edematous cerebral tissue to oxidize isocitrate, α-ketoglutarate and succinate. These observations suggest that the effect of cerebral edema may be related to decreased high-energy phosphate metabolism with subsequent alteration of oxidative phosphorilation of some substrates.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6078168</pmid><doi>10.1016/0014-4886(67)90165-3</doi><tpages>8</tpages></addata></record> |
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| ispartof | Experimental neurology, 1967-12, Vol.19 (4), p.455-462 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acid Phosphatase - metabolism Alkaline Phosphatase - metabolism Animals Brain - metabolism Brain Edema - enzymology Brain Edema - metabolism Dinitrophenols - pharmacology Dogs Isocitrate Dehydrogenase - metabolism Oxidative Phosphorylation - drug effects Oxidoreductases - metabolism Succinate Dehydrogenase - metabolism Transaminases - metabolism Water - analysis |
| title | Oxidative metabolism of the brain in the experimental cerebral edema |
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