Hemoglobin-Seattle (α2Aβ276Glu): An Unstable Hemoglobin Causing Chronic Hemolytic Anemia

Mild to moderate chronic hemolytic anemia in a mother and her two sons was found to be associated with the presence of about 40 per cent abnormal hemoglobin of rapid electrophoretic mobility: Hb-Seattle. Hb-Seattle was found to be unstable in vitro. It was shown to be due to a replacement of alanine...

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Veröffentlicht in:	Blood 1970-08, Vol.36 (2), p.209-218
Hauptverfasser:	Huehns, E.R, Hecht, F., Yoshida, A., Stamatoyannopoulos, G., Hartman, J., Motulsky, A.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alanine - analysis Anemia, Hemolytic - complications Anemia, Hemolytic - genetics Anemia, Hemolytic - therapy Anemia, Hypochromic - complications Anemia, Hypochromic - drug therapy Blood Protein Electrophoresis Blood Transfusion Bone Marrow Examination Child Child, Preschool Chromatography Chromium Isotopes Cytoplasmic Granules Dextrans Erythrocyte Aging Erythrocytes - analysis Erythrocytes - cytology Female Gels Glutamates - analysis Glutamates - metabolism Hemoglobins, Abnormal - analysis Histidine - metabolism Humans Iron - blood Iron - therapeutic use Male Methemoglobin - analysis Molecular Weight Peptides - analysis Spectrum Analysis Spleen - metabolism Starch
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