Immune Cross-reactivity of Penicillin and Cephalothin

WE recently described positive direct Coombs tests in patients receiving sodium cephalothin 1 . Because most normal sera caused the in vitro agglutination of red cells coated with cephalothin, we concluded that some of the positive direct Coombs tests must be related to non-immune binding of a serum...

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Veröffentlicht in:	Nature (London) 1967-12, Vol.216 (5119), p.1026-1027
Hauptverfasser:	GRALNICK, HARVEY R., MCGINNISS, MARY H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglutination Tests Cephalothin Hemagglutination Humanities and Social Sciences Humans In Vitro Techniques letter multidisciplinary Penicillin Resistance Penicillins Protein Binding Science
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description	WE recently described positive direct Coombs tests in patients receiving sodium cephalothin 1 . Because most normal sera caused the in vitro agglutination of red cells coated with cephalothin, we concluded that some of the positive direct Coombs tests must be related to non-immune binding of a serum protein–cephalothin complex to the red cell surface. We also suggested the possibility that some of these test sera contained anti-penicillin agglutinins.
doi_str_mv	10.1038/2161026a0
format	Article
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source	MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online
subjects	Agglutination Tests Cephalothin Hemagglutination Humanities and Social Sciences Humans In Vitro Techniques letter multidisciplinary Penicillin Resistance Penicillins Protein Binding Science
title	Immune Cross-reactivity of Penicillin and Cephalothin
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