Increased Conversion of Tyrosine to Catecholamines in the Intact Rat Following Elevation of Tissue Tyrosine Hydroxylase Levels by Administered Phenoxybenzamine

When phenoxybenzamine (20 mg/kg) was administered to rats for 2 consecutive days, a 2-fold increase in tryosine hydroxylase relative to controls was observed in adrenal and heart homogenates. A 4-6-fold increase in the incorporation of label from 14 C-L-tyrosine into catecholamines was observed foll...

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