Combined radiotherapy, surgery and chemotherapy in carcinoma of the bladder
A 5‐year experience in 109 patients with cancer of the bladder treated by combination radiotherapy, surgery and chemotherapy is reviewed. This combined therapy did not improve the poor outlook for patients with invasive (stages C or D) tumors. The study reveals that, when the bladder is preserved in...
Gespeichert in:
| Veröffentlicht in: | Cancer 1967-11, Vol.20 (11), p.1879-1885 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1885 |
|---|---|
| container_issue | 11 |
| container_start_page | 1879 |
| container_title | Cancer |
| container_volume | 20 |
| creator | Veenema, Ralph J. Guttmann, Ruth Uson, Aurelio C. Sagerman, Robert H. Dean, Archie L. Ciardullo, Louis |
| description | A 5‐year experience in 109 patients with cancer of the bladder treated by combination radiotherapy, surgery and chemotherapy is reviewed. This combined therapy did not improve the poor outlook for patients with invasive (stages C or D) tumors. The study reveals that, when the bladder is preserved in stage B carcinoma by partial cystectomy or endoscopic excision, postoperative radiotherapy should be added to bring the total dosage to a full therapeutic level. In large bulky Stage A tumors preoperative radiotherapy seems to be distinctly valuable in reducing tumor size and clarifying the extent of pathology. It thus aids in the selection of the surgical approach to the tumors. More definitive biopsies could be done after the preoperative radiation. In such patients preoperative radiation make technically possible partial cystectomy or endoscopic resection rather than total cystectomy. In these stage A tumors, when the bladder is preserved, postoperative instillations of Thio‐TEPA into the bladder is used to supplement the preoperative radiotherapy. |
| doi_str_mv | 10.1002/1097-0142(196711)20:11<1879::AID-CNCR2820201113>3.0.CO;2-N |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_84610059</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>84610059</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3833-bfcad02c80208b08f84dc2c661e6423ce741c316e7ccd5adc03280ea0d32dcad3</originalsourceid><addsrcrecordid>eNqVkFuLE0EQhRtR1uzqTxD6SRScWNU9memJIuyOt8UlAVEQX4qe7hp3ZC6xe4Pk39shcUEfBJ-KqlPnVPEJcYEwRwD1HKEqM8BcPcGqKBGfKlgivkRTVsvl-eXrrF7VH5VRoAAR9Ss9h3m9fqGy1R0xuzXfFTMAMNki11_ui9MYv6e2VAt9Ik7yqsiTfyY-1NPQdCN7GazvpptrDnazeybjNnzjsJN29NJd8_Bbkd0onQ2uG6fByqmVaS6b3nrP4YG419o-8sNjPROf3775VL_PrtbvLuvzq8xpo3XWtM56UM6k900DpjW5d8oVBXKRK-24zNFpLLh0zi-sd6CVAbbgtfLJqs_E40PuJkw_thxvaOii4763I0_bSCYvEsZFlRa_HhZdmGIM3NImdIMNO0KgPWnaw6I9LDqQJpUEpD1pokSa_iRNmoDqNSlapfBHxy-2zcD-NvqINul80H92Pe_-6_I_D_-l6F_SF5tz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>84610059</pqid></control><display><type>article</type><title>Combined radiotherapy, surgery and chemotherapy in carcinoma of the bladder</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Veenema, Ralph J. ; Guttmann, Ruth ; Uson, Aurelio C. ; Sagerman, Robert H. ; Dean, Archie L. ; Ciardullo, Louis</creator><creatorcontrib>Veenema, Ralph J. ; Guttmann, Ruth ; Uson, Aurelio C. ; Sagerman, Robert H. ; Dean, Archie L. ; Ciardullo, Louis</creatorcontrib><description>A 5‐year experience in 109 patients with cancer of the bladder treated by combination radiotherapy, surgery and chemotherapy is reviewed. This combined therapy did not improve the poor outlook for patients with invasive (stages C or D) tumors. The study reveals that, when the bladder is preserved in stage B carcinoma by partial cystectomy or endoscopic excision, postoperative radiotherapy should be added to bring the total dosage to a full therapeutic level. In large bulky Stage A tumors preoperative radiotherapy seems to be distinctly valuable in reducing tumor size and clarifying the extent of pathology. It thus aids in the selection of the surgical approach to the tumors. More definitive biopsies could be done after the preoperative radiation. In such patients preoperative radiation make technically possible partial cystectomy or endoscopic resection rather than total cystectomy. In these stage A tumors, when the bladder is preserved, postoperative instillations of Thio‐TEPA into the bladder is used to supplement the preoperative radiotherapy.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(196711)20:11<1879::AID-CNCR2820201113>3.0.CO;2-N</identifier><identifier>PMID: 4964820</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Biopsy ; Cystoscopy ; Female ; Humans ; Male ; Middle Aged ; Postoperative Care ; Postoperative Complications ; Preoperative Care ; Thiotepa - therapeutic use ; Urinary Bladder Neoplasms - drug therapy ; Urinary Bladder Neoplasms - mortality ; Urinary Bladder Neoplasms - radiotherapy ; Urinary Bladder Neoplasms - surgery ; Urinary Bladder Neoplasms - therapy</subject><ispartof>Cancer, 1967-11, Vol.20 (11), p.1879-1885</ispartof><rights>Copyright © 1967 American Cancer Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3833-bfcad02c80208b08f84dc2c661e6423ce741c316e7ccd5adc03280ea0d32dcad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4964820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Veenema, Ralph J.</creatorcontrib><creatorcontrib>Guttmann, Ruth</creatorcontrib><creatorcontrib>Uson, Aurelio C.</creatorcontrib><creatorcontrib>Sagerman, Robert H.</creatorcontrib><creatorcontrib>Dean, Archie L.</creatorcontrib><creatorcontrib>Ciardullo, Louis</creatorcontrib><title>Combined radiotherapy, surgery and chemotherapy in carcinoma of the bladder</title><title>Cancer</title><addtitle>Cancer</addtitle><description>A 5‐year experience in 109 patients with cancer of the bladder treated by combination radiotherapy, surgery and chemotherapy is reviewed. This combined therapy did not improve the poor outlook for patients with invasive (stages C or D) tumors. The study reveals that, when the bladder is preserved in stage B carcinoma by partial cystectomy or endoscopic excision, postoperative radiotherapy should be added to bring the total dosage to a full therapeutic level. In large bulky Stage A tumors preoperative radiotherapy seems to be distinctly valuable in reducing tumor size and clarifying the extent of pathology. It thus aids in the selection of the surgical approach to the tumors. More definitive biopsies could be done after the preoperative radiation. In such patients preoperative radiation make technically possible partial cystectomy or endoscopic resection rather than total cystectomy. In these stage A tumors, when the bladder is preserved, postoperative instillations of Thio‐TEPA into the bladder is used to supplement the preoperative radiotherapy.</description><subject>Biopsy</subject><subject>Cystoscopy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Postoperative Care</subject><subject>Postoperative Complications</subject><subject>Preoperative Care</subject><subject>Thiotepa - therapeutic use</subject><subject>Urinary Bladder Neoplasms - drug therapy</subject><subject>Urinary Bladder Neoplasms - mortality</subject><subject>Urinary Bladder Neoplasms - radiotherapy</subject><subject>Urinary Bladder Neoplasms - surgery</subject><subject>Urinary Bladder Neoplasms - therapy</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkFuLE0EQhRtR1uzqTxD6SRScWNU9memJIuyOt8UlAVEQX4qe7hp3ZC6xe4Pk39shcUEfBJ-KqlPnVPEJcYEwRwD1HKEqM8BcPcGqKBGfKlgivkRTVsvl-eXrrF7VH5VRoAAR9Ss9h3m9fqGy1R0xuzXfFTMAMNki11_ui9MYv6e2VAt9Ik7yqsiTfyY-1NPQdCN7GazvpptrDnazeybjNnzjsJN29NJd8_Bbkd0onQ2uG6fByqmVaS6b3nrP4YG419o-8sNjPROf3775VL_PrtbvLuvzq8xpo3XWtM56UM6k900DpjW5d8oVBXKRK-24zNFpLLh0zi-sd6CVAbbgtfLJqs_E40PuJkw_thxvaOii4763I0_bSCYvEsZFlRa_HhZdmGIM3NImdIMNO0KgPWnaw6I9LDqQJpUEpD1pokSa_iRNmoDqNSlapfBHxy-2zcD-NvqINul80H92Pe_-6_I_D_-l6F_SF5tz</recordid><startdate>196711</startdate><enddate>196711</enddate><creator>Veenema, Ralph J.</creator><creator>Guttmann, Ruth</creator><creator>Uson, Aurelio C.</creator><creator>Sagerman, Robert H.</creator><creator>Dean, Archie L.</creator><creator>Ciardullo, Louis</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196711</creationdate><title>Combined radiotherapy, surgery and chemotherapy in carcinoma of the bladder</title><author>Veenema, Ralph J. ; Guttmann, Ruth ; Uson, Aurelio C. ; Sagerman, Robert H. ; Dean, Archie L. ; Ciardullo, Louis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3833-bfcad02c80208b08f84dc2c661e6423ce741c316e7ccd5adc03280ea0d32dcad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Biopsy</topic><topic>Cystoscopy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Postoperative Care</topic><topic>Postoperative Complications</topic><topic>Preoperative Care</topic><topic>Thiotepa - therapeutic use</topic><topic>Urinary Bladder Neoplasms - drug therapy</topic><topic>Urinary Bladder Neoplasms - mortality</topic><topic>Urinary Bladder Neoplasms - radiotherapy</topic><topic>Urinary Bladder Neoplasms - surgery</topic><topic>Urinary Bladder Neoplasms - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Veenema, Ralph J.</creatorcontrib><creatorcontrib>Guttmann, Ruth</creatorcontrib><creatorcontrib>Uson, Aurelio C.</creatorcontrib><creatorcontrib>Sagerman, Robert H.</creatorcontrib><creatorcontrib>Dean, Archie L.</creatorcontrib><creatorcontrib>Ciardullo, Louis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Veenema, Ralph J.</au><au>Guttmann, Ruth</au><au>Uson, Aurelio C.</au><au>Sagerman, Robert H.</au><au>Dean, Archie L.</au><au>Ciardullo, Louis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined radiotherapy, surgery and chemotherapy in carcinoma of the bladder</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1967-11</date><risdate>1967</risdate><volume>20</volume><issue>11</issue><spage>1879</spage><epage>1885</epage><pages>1879-1885</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>A 5‐year experience in 109 patients with cancer of the bladder treated by combination radiotherapy, surgery and chemotherapy is reviewed. This combined therapy did not improve the poor outlook for patients with invasive (stages C or D) tumors. The study reveals that, when the bladder is preserved in stage B carcinoma by partial cystectomy or endoscopic excision, postoperative radiotherapy should be added to bring the total dosage to a full therapeutic level. In large bulky Stage A tumors preoperative radiotherapy seems to be distinctly valuable in reducing tumor size and clarifying the extent of pathology. It thus aids in the selection of the surgical approach to the tumors. More definitive biopsies could be done after the preoperative radiation. In such patients preoperative radiation make technically possible partial cystectomy or endoscopic resection rather than total cystectomy. In these stage A tumors, when the bladder is preserved, postoperative instillations of Thio‐TEPA into the bladder is used to supplement the preoperative radiotherapy.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>4964820</pmid><doi>10.1002/1097-0142(196711)20:11<1879::AID-CNCR2820201113>3.0.CO;2-N</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0008-543X |
| ispartof | Cancer, 1967-11, Vol.20 (11), p.1879-1885 |
| issn | 0008-543X 1097-0142 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84610059 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Biopsy Cystoscopy Female Humans Male Middle Aged Postoperative Care Postoperative Complications Preoperative Care Thiotepa - therapeutic use Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - radiotherapy Urinary Bladder Neoplasms - surgery Urinary Bladder Neoplasms - therapy |
| title | Combined radiotherapy, surgery and chemotherapy in carcinoma of the bladder |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T20%3A41%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Combined%20radiotherapy,%20surgery%20and%20chemotherapy%20in%20carcinoma%20of%20the%20bladder&rft.jtitle=Cancer&rft.au=Veenema,%20Ralph%20J.&rft.date=1967-11&rft.volume=20&rft.issue=11&rft.spage=1879&rft.epage=1885&rft.pages=1879-1885&rft.issn=0008-543X&rft.eissn=1097-0142&rft_id=info:doi/10.1002/1097-0142(196711)20:11%3C1879::AID-CNCR2820201113%3E3.0.CO;2-N&rft_dat=%3Cproquest_cross%3E84610059%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=84610059&rft_id=info:pmid/4964820&rfr_iscdi=true |