Intestinal absorption of carnosine and its constituent amino acids in man

Serum concentrations of β-alanine and l-histidine are compared in five normal adults after ingestion of the dipeptide carnosine (β-alanyl-l-histidine) and after equivalent amounts of the constituent free amino acids. The results indicate that absorption is significantly more rapid after the ingestio...

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Veröffentlicht in:	Gut 1970-03, Vol.11 (3), p.250-254
Hauptverfasser:	Asatoor, A. M., Bandoh, J. K., Lant, A. F., Milne, M. D., Navab, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - blood Alanine - metabolism Dipeptides - metabolism Hartnup Disease - blood Hartnup Disease - metabolism Histidine - blood Histidine - metabolism Humans Intestinal Absorption
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description	Serum concentrations of β-alanine and l-histidine are compared in five normal adults after ingestion of the dipeptide carnosine (β-alanyl-l-histidine) and after equivalent amounts of the constituent free amino acids. The results indicate that absorption is significantly more rapid after the ingestion of the amino acids than after the dipeptide. The use of the test in a case of Hartnup disease suggests that carnosine is taken up by intestinal cells as the dipeptide, but subsequent hydrolysis and delivery of the constituent amino acids to the portal blood is a slower process than transport of the free amino acids themselves.
doi_str_mv	10.1136/gut.11.3.250
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subjects	Alanine - blood Alanine - metabolism Dipeptides - metabolism Hartnup Disease - blood Hartnup Disease - metabolism Histidine - blood Histidine - metabolism Humans Intestinal Absorption
title	Intestinal absorption of carnosine and its constituent amino acids in man
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