Relapses of thromboembolic disease after discontinued anticoagulant therapy: A comparison of the incidence after abrupt and after gradual termination of treatment

On 89 occasions anticoagulant therapy for thromboembolic disease was stopped electively. Treatment was reduced gradually over a six week period on 42 occasions and stopped abruptly on 47. Patients were followed up for four months afterwards. The relapse rate was 21 per cent after stopping treatment...

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Veröffentlicht in:	The American journal of cardiology 1967-11, Vol.20 (5), p.670-673
Hauptverfasser:	Michaels, Leon, Beamish, Robert E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants - administration & dosage Coronary Disease - drug therapy Humans Intracranial Embolism and Thrombosis - drug therapy Thromboembolism - drug therapy Thrombophlebitis - drug therapy
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description	On 89 occasions anticoagulant therapy for thromboembolic disease was stopped electively. Treatment was reduced gradually over a six week period on 42 occasions and stopped abruptly on 47. Patients were followed up for four months afterwards. The relapse rate was 21 per cent after stopping treatment abruptly and 17 per cent after doing so gradually. The difference is not statistically significant, and suggests that gradual reduction in anticoagulant dosage over a period of weeks is without appreciable benefit as far as preventing recurrence of thromboembolic disease is concerned.
doi_str_mv	10.1016/0002-9149(67)90010-0
format	Article
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Treatment was reduced gradually over a six week period on 42 occasions and stopped abruptly on 47. Patients were followed up for four months afterwards. The relapse rate was 21 per cent after stopping treatment abruptly and 17 per cent after doing so gradually. 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The difference is not statistically significant, and suggests that gradual reduction in anticoagulant dosage over a period of weeks is without appreciable benefit as far as preventing recurrence of thromboembolic disease is concerned.</description><subject>Anticoagulants - administration & dosage</subject><subject>Coronary Disease - drug therapy</subject><subject>Humans</subject><subject>Intracranial Embolism and Thrombosis - drug therapy</subject><subject>Thromboembolism - drug therapy</subject><subject>Thrombophlebitis - drug therapy</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9Ud1qFjEQDWKpn61voJArqRdbk_3JjxdCKVqFgiD1OswmszWyu1mTrNDX8Umb9dt6EXIm58whM4eQ15xdcsbFe8ZYXWne6gsh32nGOKvYM3LgSuqKa948J4f_khfkZUq_Ssl5J07JqWCiUOxA_n7HEZaEiYaB5p8xTH3AckZvqfMJISGFIWPcKhvm7OcVHYUCbID7dSyo9GGE5eEDvaI2TAtEn8J8NETqZ-sdzvbJB_q4Lrk4uP3hPoJbYaQFT36G7PfeiJAnnPM5ORlgTPhqv8_Ij8-f7q6_VLffbr5eX91WWAueq6EbFLDewoBcqFYr4NK6jumaWbSgdC07oWXjZNG3dSvbXrf9MFguRV8jb87I26PvEsPvFVM2UxkZxzIihjUZ1XaqaZQqwje7cO0ndGaJfoL4YPalFv7jkcfy2z8eo0nWbxtwPqLNxgVvODNbiGZLyGwJGSHNvxANax4BVauRuQ</recordid><startdate>196711</startdate><enddate>196711</enddate><creator>Michaels, Leon</creator><creator>Beamish, Robert E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>196711</creationdate><title>Relapses of thromboembolic disease after discontinued anticoagulant therapy: A comparison of the incidence after abrupt and after gradual termination of treatment</title><author>Michaels, Leon ; Beamish, Robert E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e261t-f5f8a0bcafe168498a17cd50920ceca892756973d7e2642474b94bffc176b2e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Anticoagulants - administration & dosage</topic><topic>Coronary Disease - drug therapy</topic><topic>Humans</topic><topic>Intracranial Embolism and Thrombosis - drug therapy</topic><topic>Thromboembolism - drug therapy</topic><topic>Thrombophlebitis - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Michaels, Leon</creatorcontrib><creatorcontrib>Beamish, Robert E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Michaels, Leon</au><au>Beamish, Robert E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relapses of thromboembolic disease after discontinued anticoagulant therapy: A comparison of the incidence after abrupt and after gradual termination of treatment</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1967-11</date><risdate>1967</risdate><volume>20</volume><issue>5</issue><spage>670</spage><epage>673</epage><pages>670-673</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><abstract>On 89 occasions anticoagulant therapy for thromboembolic disease was stopped electively. 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subjects	Anticoagulants - administration & dosage Coronary Disease - drug therapy Humans Intracranial Embolism and Thrombosis - drug therapy Thromboembolism - drug therapy Thrombophlebitis - drug therapy
title	Relapses of thromboembolic disease after discontinued anticoagulant therapy: A comparison of the incidence after abrupt and after gradual termination of treatment
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