Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells

Mouse CCL8 is a CC chemokine of the monocyte chemoattractant protein (MCP) family whose biological activity and receptor usage have remained elusive. Here we show that CCL8 is highly expressed in the skin, where it serves as an agonist for the chemokine receptor CCR8 but not for CCR2. This distingui...

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Veröffentlicht in:	Nature immunology 2011-02, Vol.12 (2), p.167-177
Hauptverfasser:	Islam, Sabina A, Chang, Daniel S, Colvin, Richard A, Byrne, Mike H, McCully, Michelle L, Moser, Bernhard, Lira, Sergio A, Charo, Israel F, Luster, Andrew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals Calcium Signaling - immunology Cells, Cultured Chemokine CCL1 - genetics Chemokine CCL1 - immunology Chemokine CCL1 - metabolism Chemokine CCL8 - genetics Chemokine CCL8 - immunology Chemokine CCL8 - metabolism Chemotaxis - genetics Chemotaxis - immunology Cloning, Molecular Dermatitis, Atopic - immunology Disease Models, Animal Humans Interleukin-5 - immunology Interleukin-5 - metabolism Mice Mice, Inbred C57BL Mice, Knockout Receptors, Lymphocyte Homing - immunology Skin - pathology Th2 Cells - immunology Th2 Cells - metabolism Th2 Cells - pathology
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