Peripheral Administration of Loperamide and Methylnaloxone Decreases the Degree of Anxiety in Rats
We studied the effect of μ-opioid receptor ligands on anxious and depressive behavior of rats. Intragastric administration of loperamide and methylnaloxone reduced animal anxiety evaluated by an increase in the number of entries into and time spent in open arms of the elevated plus-maze. μ-Opioid re...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2010-09, Vol.149 (3), p.273-275 |
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| creator | Sudakov, S. K Bashkatova, V. G Kolpakov, A. A Trigub, M. M |
| description | We studied the effect of μ-opioid receptor ligands on anxious and depressive behavior of rats. Intragastric administration of loperamide and methylnaloxone reduced animal anxiety evaluated by an increase in the number of entries into and time spent in open arms of the elevated plus-maze. μ-Opioid receptor agonist loperamide had the most pronounced anxiolytic effect. Analysis of animal behavior in the forced swimming test showed that administration of μ-opioid receptor antagonist methylnaloxone reduced the latency of the first submersion, increased the total time of submersion episodes, and shortened the time of active swimming, which attested to depressive properties of this agent. Loperamide had little effect on behavior of rats in the forced swimming test. Thus, μ-opioid receptor agonist loperamide has the antianxiety properties and produced no sedative effect. Therefore, this agent holds much promise as an anxiolytic drug. |
| doi_str_mv | 10.1007/s10517-010-0925-0 |
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Thus, μ-opioid receptor agonist loperamide has the antianxiety properties and produced no sedative effect. Therefore, this agent holds much promise as an anxiolytic drug.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-010-0925-0</identifier><identifier>PMID: 21246080</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Analysis of Variance ; Animal behavior ; Animals ; Antianxiety agents ; Anxiety - drug therapy ; anxiolytic effect ; Behavior, Animal - drug effects ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; central and peripheral μ-opioid receptors ; elevated plus-maze ; Internal Medicine ; Laboratory Medicine ; Loperamide ; Loperamide - administration & dosage ; Loperamide - pharmacology ; Loperamide - therapeutic use ; Male ; Maze Learning - drug effects ; methylnaloxone ; Naloxone - administration & dosage ; Naloxone - analogs & derivatives ; Naloxone - pharmacology ; Naloxone - therapeutic use ; Pathology ; Physiology ; Quaternary Ammonium Compounds - administration & dosage ; Quaternary Ammonium Compounds - pharmacology ; Quaternary Ammonium Compounds - therapeutic use ; Rats ; Rats, Wistar ; Receptors, Opioid, mu - antagonists & inhibitors ; Swimming - psychology ; Time Factors</subject><ispartof>Bulletin of experimental biology and medicine, 2010-09, Vol.149 (3), p.273-275</ispartof><rights>Springer Science+Business Media, Inc. 2010</rights><rights>COPYRIGHT 2010 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-6b78a9931309d2c928ce0e11c956526bef75f9ca7854da8dfcc8054236b9c8933</citedby><cites>FETCH-LOGICAL-c492t-6b78a9931309d2c928ce0e11c956526bef75f9ca7854da8dfcc8054236b9c8933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-010-0925-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-010-0925-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21246080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sudakov, S. K</creatorcontrib><creatorcontrib>Bashkatova, V. G</creatorcontrib><creatorcontrib>Kolpakov, A. A</creatorcontrib><creatorcontrib>Trigub, M. M</creatorcontrib><title>Peripheral Administration of Loperamide and Methylnaloxone Decreases the Degree of Anxiety in Rats</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We studied the effect of μ-opioid receptor ligands on anxious and depressive behavior of rats. Intragastric administration of loperamide and methylnaloxone reduced animal anxiety evaluated by an increase in the number of entries into and time spent in open arms of the elevated plus-maze. μ-Opioid receptor agonist loperamide had the most pronounced anxiolytic effect. Analysis of animal behavior in the forced swimming test showed that administration of μ-opioid receptor antagonist methylnaloxone reduced the latency of the first submersion, increased the total time of submersion episodes, and shortened the time of active swimming, which attested to depressive properties of this agent. Loperamide had little effect on behavior of rats in the forced swimming test. Thus, μ-opioid receptor agonist loperamide has the antianxiety properties and produced no sedative effect. Therefore, this agent holds much promise as an anxiolytic drug.</description><subject>Analysis of Variance</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Antianxiety agents</subject><subject>Anxiety - drug therapy</subject><subject>anxiolytic effect</subject><subject>Behavior, Animal - drug effects</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>central and peripheral μ-opioid receptors</subject><subject>elevated plus-maze</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Loperamide</subject><subject>Loperamide - administration & dosage</subject><subject>Loperamide - pharmacology</subject><subject>Loperamide - therapeutic use</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>methylnaloxone</subject><subject>Naloxone - administration & dosage</subject><subject>Naloxone - analogs & derivatives</subject><subject>Naloxone - pharmacology</subject><subject>Naloxone - therapeutic use</subject><subject>Pathology</subject><subject>Physiology</subject><subject>Quaternary Ammonium Compounds - administration & dosage</subject><subject>Quaternary Ammonium Compounds - pharmacology</subject><subject>Quaternary Ammonium Compounds - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Opioid, mu - antagonists & inhibitors</subject><subject>Swimming - psychology</subject><subject>Time Factors</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kVtv1DAQhS0EotvCD-AFIpDgKWVsx4n9uCrlIi0CAX22HGeycZXEi51I3X-Po5RLEUJ-sGbmOyPNOYQ8oXBOAarXkYKgVQ4UclBM5HCPbKioeC4Zo_fJBhKUF1LKE3Ia4_VSQkkfkhNGWVGChA2pP2Nwhw6D6bNtM7jRxSmYyfkx822284c0GVyDmRmb7CNO3bEfTe9v_IjZG7QBTcSYTd1S7QPiotqONw6nY-bG7IuZ4iPyoDV9xMe3_xm5env57eJ9vvv07sPFdpfbQrEpL-tKGqU45aAaZhWTFgEptUqUgpU1tpVolTWVFEVjZNNaK0EUjJe1slJxfkZerXsPwX-fMU56cNFi35sR_Ry1LERVFrQUiXz-F3nt55DuiroqZFWCUDJBL1Zob3rUbmx9MsYuK_WWc1Ymn4El6vwfVHoNDs4ml1qX-ncEL_8QdGj6qYu-nxfL412QrqANPsaArT4EN5hw1BT0Er9e49cpfr3EryFpnt4eNtcDNr8UP_NOAFuBmEbjHsPvy_-39dkqao3XZh9c1FdfGaSgqJQcKsF_AL0dwFM</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Sudakov, S. 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K ; Bashkatova, V. G ; Kolpakov, A. A ; Trigub, M. 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Analysis of animal behavior in the forced swimming test showed that administration of μ-opioid receptor antagonist methylnaloxone reduced the latency of the first submersion, increased the total time of submersion episodes, and shortened the time of active swimming, which attested to depressive properties of this agent. Loperamide had little effect on behavior of rats in the forced swimming test. Thus, μ-opioid receptor agonist loperamide has the antianxiety properties and produced no sedative effect. Therefore, this agent holds much promise as an anxiolytic drug.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>21246080</pmid><doi>10.1007/s10517-010-0925-0</doi><tpages>3</tpages></addata></record> |
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| subjects | Analysis of Variance Animal behavior Animals Antianxiety agents Anxiety - drug therapy anxiolytic effect Behavior, Animal - drug effects Biomedical and Life Sciences Biomedicine Cell Biology central and peripheral μ-opioid receptors elevated plus-maze Internal Medicine Laboratory Medicine Loperamide Loperamide - administration & dosage Loperamide - pharmacology Loperamide - therapeutic use Male Maze Learning - drug effects methylnaloxone Naloxone - administration & dosage Naloxone - analogs & derivatives Naloxone - pharmacology Naloxone - therapeutic use Pathology Physiology Quaternary Ammonium Compounds - administration & dosage Quaternary Ammonium Compounds - pharmacology Quaternary Ammonium Compounds - therapeutic use Rats Rats, Wistar Receptors, Opioid, mu - antagonists & inhibitors Swimming - psychology Time Factors |
| title | Peripheral Administration of Loperamide and Methylnaloxone Decreases the Degree of Anxiety in Rats |
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