A Study of Free Energy Relationships in the Urea-Sodium Sulfate-Water System

A Study of Free Energy Relationships in the Urea-Sodium Sulfate-Water System

Activity coefficients for each of the components, urea and sodium sulfate, in their ternary mixtures with water have been obtained using the isopiestic vapor pressure method over the concentration ranges 0 to 19.4 molal urea and 0 to 2.4 molal Na 2 SO 4 . At the lower molalities of the solutes, ther...

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Veröffentlicht in:The Journal of biological chemistry 1970-05, Vol.245 (9), p.2432-2437
Hauptverfasser: Schrier, E E, Robinson, R A
Format: Artikel
Sprache:eng
Schlagworte:
Osmolar Concentration
Peptides
Protein Denaturation
Sodium
Sulfates
Thermodynamics
Urea
Water
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Zusammenfassung:Activity coefficients for each of the components, urea and sodium sulfate, in their ternary mixtures with water have been obtained using the isopiestic vapor pressure method over the concentration ranges 0 to 19.4 molal urea and 0 to 2.4 molal Na 2 SO 4 . At the lower molalities of the solutes, there is mutual salting-in of the components which changes to salting-out at 0.4 molal Na 2 SO 4 and 5 molal urea. These results are considered as a model for certain interactions in the denaturation of proteins by electrolytes.
ISSN:0021-9258
1083-351X
DOI:10.1016/s0021-9258(18)63170-9