Distribution of an Arginine–Lysine Interchange in the Invariable Half of Human L-Type Bence-Jones Proteins
SEROLOGICAL reagents have been used to identify allelic antigenic determinants of the peptide chains of immunoglobulins 1 . Several allotypic determinants of the heavy chains of human immunoglobulins have been identified 2 and their distribution in human populations 3 has been investigated. Only a f...
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| Veröffentlicht in: | Nature (London) 1967-10, Vol.216 (5110), p.56-57 |
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| creator | QUATTROCCHI, R. CIOLI, D. BAGLIONI, C. |
| description | SEROLOGICAL reagents have been used to identify allelic antigenic determinants of the peptide chains of immunoglobulins
1
. Several allotypic determinants of the heavy chains of human immunoglobulins have been identified
2
and their distribution in human populations
3
has been investigated. Only a few allotypic determinants of the K-type light chain of human immunoglobulins have been identified
2
and one of these has been correlated with an amino-acid interchange in the invariable half of these peptide chains
4–6
. No homologous serological reagent has been available for the study of the L-type light chain. |
| doi_str_mv | 10.1038/216056a0 |
| format | Article |
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1
. Several allotypic determinants of the heavy chains of human immunoglobulins have been identified
2
and their distribution in human populations
3
has been investigated. Only a few allotypic determinants of the K-type light chain of human immunoglobulins have been identified
2
and one of these has been correlated with an amino-acid interchange in the invariable half of these peptide chains
4–6
. No homologous serological reagent has been available for the study of the L-type light chain.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/216056a0</identifier><identifier>PMID: 4167491</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amino Acid Sequence ; Arginine ; Bence Jones Protein - analysis ; Blood Protein Electrophoresis ; gamma-Globulins - analysis ; Humanities and Social Sciences ; Humans ; letter ; Lysine ; Molecular Biology ; multidisciplinary ; Peptides - analysis ; Science ; Science (multidisciplinary) ; Trypsin</subject><ispartof>Nature (London), 1967-10, Vol.216 (5110), p.56-57</ispartof><rights>Springer Nature Limited 1967</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c312t-714dde2d27a9be8061d88967096db0ed072388122a42631a888a2fa83abb41493</citedby><cites>FETCH-LOGICAL-c312t-714dde2d27a9be8061d88967096db0ed072388122a42631a888a2fa83abb41493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/216056a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/216056a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4167491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>QUATTROCCHI, R.</creatorcontrib><creatorcontrib>CIOLI, D.</creatorcontrib><creatorcontrib>BAGLIONI, C.</creatorcontrib><title>Distribution of an Arginine–Lysine Interchange in the Invariable Half of Human L-Type Bence-Jones Proteins</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>SEROLOGICAL reagents have been used to identify allelic antigenic determinants of the peptide chains of immunoglobulins
1
. Several allotypic determinants of the heavy chains of human immunoglobulins have been identified
2
and their distribution in human populations
3
has been investigated. Only a few allotypic determinants of the K-type light chain of human immunoglobulins have been identified
2
and one of these has been correlated with an amino-acid interchange in the invariable half of these peptide chains
4–6
. No homologous serological reagent has been available for the study of the L-type light chain.</description><subject>Amino Acid Sequence</subject><subject>Arginine</subject><subject>Bence Jones Protein - analysis</subject><subject>Blood Protein Electrophoresis</subject><subject>gamma-Globulins - analysis</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>letter</subject><subject>Lysine</subject><subject>Molecular Biology</subject><subject>multidisciplinary</subject><subject>Peptides - analysis</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Trypsin</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkE1OwzAQhS0EKqUgcQEkrxAsArbj2M6ylJ8WRYJFWUdOMmldJU6xE6TuuAM35CSkamHDakbzvvekeQidU3JDSahuGRUkEpocoCHlUgRcKHmIhoQwFRAVimN04v2KEBJRyQdowKmQPKZDVN0b3zqTda1pLG5KrC0eu4WxxsL351ey8f2CZ7YFly-1XQA2FrfL7elDO6OzCvBUV-XWOu3q3p0E880a8B3YHILnxoLHr65pwVh_io5KXXk4288Rent8mE-mQfLyNJuMkyAPKWsDSXlRACuY1HEGighaKBULSWJRZAQKIlmoFGVMcyZCqpVSmpVahTrLOOVxOEKXu9y1a9478G1aG59DVWkLTedTxaMojJnswasdmLvGewdlunam1m6TUpJui01_i-3Ri31ml9VQ_IH7Jnv9eqf7Xul7cumq6Zzt3_yf9QPVB3_o</recordid><startdate>19671007</startdate><enddate>19671007</enddate><creator>QUATTROCCHI, R.</creator><creator>CIOLI, D.</creator><creator>BAGLIONI, C.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19671007</creationdate><title>Distribution of an Arginine–Lysine Interchange in the Invariable Half of Human L-Type Bence-Jones Proteins</title><author>QUATTROCCHI, R. ; CIOLI, D. ; BAGLIONI, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c312t-714dde2d27a9be8061d88967096db0ed072388122a42631a888a2fa83abb41493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Amino Acid Sequence</topic><topic>Arginine</topic><topic>Bence Jones Protein - analysis</topic><topic>Blood Protein Electrophoresis</topic><topic>gamma-Globulins - analysis</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>letter</topic><topic>Lysine</topic><topic>Molecular Biology</topic><topic>multidisciplinary</topic><topic>Peptides - analysis</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Trypsin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>QUATTROCCHI, R.</creatorcontrib><creatorcontrib>CIOLI, D.</creatorcontrib><creatorcontrib>BAGLIONI, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>QUATTROCCHI, R.</au><au>CIOLI, D.</au><au>BAGLIONI, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of an Arginine–Lysine Interchange in the Invariable Half of Human L-Type Bence-Jones Proteins</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1967-10-07</date><risdate>1967</risdate><volume>216</volume><issue>5110</issue><spage>56</spage><epage>57</epage><pages>56-57</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>SEROLOGICAL reagents have been used to identify allelic antigenic determinants of the peptide chains of immunoglobulins
1
. Several allotypic determinants of the heavy chains of human immunoglobulins have been identified
2
and their distribution in human populations
3
has been investigated. Only a few allotypic determinants of the K-type light chain of human immunoglobulins have been identified
2
and one of these has been correlated with an amino-acid interchange in the invariable half of these peptide chains
4–6
. No homologous serological reagent has been available for the study of the L-type light chain.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>4167491</pmid><doi>10.1038/216056a0</doi><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1967-10, Vol.216 (5110), p.56-57 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_84553927 |
| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Amino Acid Sequence Arginine Bence Jones Protein - analysis Blood Protein Electrophoresis gamma-Globulins - analysis Humanities and Social Sciences Humans letter Lysine Molecular Biology multidisciplinary Peptides - analysis Science Science (multidisciplinary) Trypsin |
| title | Distribution of an Arginine–Lysine Interchange in the Invariable Half of Human L-Type Bence-Jones Proteins |
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