Effects of propranolol on patients with complete heart block and implanted pacemakers
The effects of beta-adrenergic blockade with propranolol were studied in 10 patients with complete heart block and fixed rate internal pacemakers. The patients were grouped according to the absence or presence of premature systoles before propranolol was given. In the patients with premature systole...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 1967-10, Vol.36 (4), p.534-538 |
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| container_end_page | 538 |
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| container_issue | 4 |
| container_start_page | 534 |
| container_title | Circulation (New York, N.Y.) |
| container_volume | 36 |
| creator | Donoso, E Cohn, L J Newman, B J Bloom, H S Stein, W G Friedberg, C K |
| description | The effects of beta-adrenergic blockade with propranolol were studied in 10 patients with complete heart block and fixed rate internal pacemakers. The patients were grouped according to the absence or presence of premature systoles before propranolol was given. In the patients with premature systoles propranolol was uniformly effective in abolishing the premature systoles. Propranolol was found to increase the systemic venous pressure, to decrease the cardiac output, and to lower myocardial contractility both at rest and during exercise in both groups. Since the heart rate was fixed, it was concluded that beta-adrenergic blockade has a significant negative inotropic effect, in addition to the chronotropic effect. |
| doi_str_mv | 10.1161/01.CIR.36.4.534 |
| format | Article |
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The patients were grouped according to the absence or presence of premature systoles before propranolol was given. In the patients with premature systoles propranolol was uniformly effective in abolishing the premature systoles. Propranolol was found to increase the systemic venous pressure, to decrease the cardiac output, and to lower myocardial contractility both at rest and during exercise in both groups. Since the heart rate was fixed, it was concluded that beta-adrenergic blockade has a significant negative inotropic effect, in addition to the chronotropic effect.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.36.4.534</identifier><identifier>PMID: 6041866</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Blood Pressure - drug effects ; Cardiac Output - drug effects ; Heart - drug effects ; Heart Block - drug therapy ; Humans ; Pacemaker, Artificial ; Propranolol - pharmacology ; Propranolol - therapeutic use ; Veins - drug effects</subject><ispartof>Circulation (New York, N.Y.), 1967-10, Vol.36 (4), p.534-538</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2884-9ef591245f60dc857009a51783715bddca84f736d7f7ddaee6488f5e016f62423</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6041866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Donoso, E</creatorcontrib><creatorcontrib>Cohn, L J</creatorcontrib><creatorcontrib>Newman, B J</creatorcontrib><creatorcontrib>Bloom, H S</creatorcontrib><creatorcontrib>Stein, W G</creatorcontrib><creatorcontrib>Friedberg, C K</creatorcontrib><title>Effects of propranolol on patients with complete heart block and implanted pacemakers</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>The effects of beta-adrenergic blockade with propranolol were studied in 10 patients with complete heart block and fixed rate internal pacemakers. The patients were grouped according to the absence or presence of premature systoles before propranolol was given. In the patients with premature systoles propranolol was uniformly effective in abolishing the premature systoles. Propranolol was found to increase the systemic venous pressure, to decrease the cardiac output, and to lower myocardial contractility both at rest and during exercise in both groups. Since the heart rate was fixed, it was concluded that beta-adrenergic blockade has a significant negative inotropic effect, in addition to the chronotropic effect.</description><subject>Aged</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiac Output - drug effects</subject><subject>Heart - drug effects</subject><subject>Heart Block - drug therapy</subject><subject>Humans</subject><subject>Pacemaker, Artificial</subject><subject>Propranolol - pharmacology</subject><subject>Propranolol - therapeutic use</subject><subject>Veins - drug effects</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1LAzEQxYMotVbPnoScvO0235s9SqkfIAhizyFNJnTt7mbdbBH_eyMtnoaZee_x-CF0S0lJqaJLQsvVy3vJVSlKycUZmlPJRCEkr8_RnBBSFxVn7BJdpfSZV8UrOUMzRQTVSs3RZh0CuCnhGPAwxmG0fWxji2OPBzs10OfXdzPtsIvd0MIEeAd2nPC2jW6Pbe9xk--2n8Bng4PO7mFM1-gi2DbBzWku0OZx_bF6Ll7fnl5WD6-FY1qLooYga8qEDIp4p2WV61pJK80rKrfeO6tFqLjyVai8twBKaB0kEKqCYoLxBbo_5ubqXwdIk-ma5KDNhSAektFCSlZrmoXLo9CNMaURghnGprPjj6HE_IE0hJoM0nBlhMkgs-PuFH3YduD_9Sdy_BfMc26G</recordid><startdate>196710</startdate><enddate>196710</enddate><creator>Donoso, E</creator><creator>Cohn, L J</creator><creator>Newman, B J</creator><creator>Bloom, H S</creator><creator>Stein, W G</creator><creator>Friedberg, C K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196710</creationdate><title>Effects of propranolol on patients with complete heart block and implanted pacemakers</title><author>Donoso, E ; Cohn, L J ; Newman, B J ; Bloom, H S ; Stein, W G ; Friedberg, C K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2884-9ef591245f60dc857009a51783715bddca84f736d7f7ddaee6488f5e016f62423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Aged</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiac Output - drug effects</topic><topic>Heart - drug effects</topic><topic>Heart Block - drug therapy</topic><topic>Humans</topic><topic>Pacemaker, Artificial</topic><topic>Propranolol - pharmacology</topic><topic>Propranolol - therapeutic use</topic><topic>Veins - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donoso, E</creatorcontrib><creatorcontrib>Cohn, L J</creatorcontrib><creatorcontrib>Newman, B J</creatorcontrib><creatorcontrib>Bloom, H S</creatorcontrib><creatorcontrib>Stein, W G</creatorcontrib><creatorcontrib>Friedberg, C K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Donoso, E</au><au>Cohn, L J</au><au>Newman, B J</au><au>Bloom, H S</au><au>Stein, W G</au><au>Friedberg, C K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of propranolol on patients with complete heart block and implanted pacemakers</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>1967-10</date><risdate>1967</risdate><volume>36</volume><issue>4</issue><spage>534</spage><epage>538</epage><pages>534-538</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><abstract>The effects of beta-adrenergic blockade with propranolol were studied in 10 patients with complete heart block and fixed rate internal pacemakers. 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| fulltext | fulltext |
| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 1967-10, Vol.36 (4), p.534-538 |
| issn | 0009-7322 1524-4539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84552981 |
| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Aged Blood Pressure - drug effects Cardiac Output - drug effects Heart - drug effects Heart Block - drug therapy Humans Pacemaker, Artificial Propranolol - pharmacology Propranolol - therapeutic use Veins - drug effects |
| title | Effects of propranolol on patients with complete heart block and implanted pacemakers |
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