Reactions of amine drugs with sugars II Synthesis and in vivo evaluation of mannose amphetamine sulfonate and N-phenylisopropyl-d-mannamine
Mannose amphetamine sulfonate was synthesized from the reaction of amphetamine bisulfite with D-mannose. N-Phenylisopropyl-D-mannamine was synthesized by catalytic hydrogenation of N-phenylisopropyl-D-mannosylamine. The products were evaluated in vivo by the Williamson activity cage method. Mannose...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1967-09, Vol.56 (9), p.1101-1103 |
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| container_end_page | 1103 |
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| container_issue | 9 |
| container_start_page | 1101 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 56 |
| creator | Griffin, J.C. Banker, G.S. |
| description | Mannose amphetamine sulfonate was synthesized from the reaction of amphetamine bisulfite with D-mannose. N-Phenylisopropyl-D-mannamine was synthesized by catalytic hydrogenation of N-phenylisopropyl-D-mannosylamine. The products were evaluated in vivo by the Williamson activity cage method. Mannose amphetamine sulfonate was found to have a significantly longer duration of activity and produced a higher level of mean activity, from 3.5hr. to 4.5hr. after administration, than dextroamphetamine sulfate. N-Phenylisopropyl-D-mannamine was found to be orally inactive at dosage levels of 10 and 50 mg./Kg. of body weight. |
| doi_str_mv | 10.1002/jps.2600560910 |
| format | Article |
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N-Phenylisopropyl-D-mannamine was synthesized by catalytic hydrogenation of N-phenylisopropyl-D-mannosylamine. The products were evaluated in vivo by the Williamson activity cage method. Mannose amphetamine sulfonate was found to have a significantly longer duration of activity and produced a higher level of mean activity, from 3.5hr. to 4.5hr. after administration, than dextroamphetamine sulfate. N-Phenylisopropyl-D-mannamine was found to be orally inactive at dosage levels of 10 and 50 mg./Kg. of body weight.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600560910</identifier><identifier>PMID: 6049694</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Amino Sugars - chemical synthesis ; Amino Sugars - pharmacology ; Animals ; Dextroamphetamine ; In Vitro Techniques ; Mannose ; Rats ; Sulfonic Acids - chemical synthesis</subject><ispartof>Journal of pharmaceutical sciences, 1967-09, Vol.56 (9), p.1101-1103</ispartof><rights>1967 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1967 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3420-23fa67b5e3250fd76d0793bad4ac12e4381cdcbd879b4c564a952c799219f23c3</citedby><cites>FETCH-LOGICAL-c3420-23fa67b5e3250fd76d0793bad4ac12e4381cdcbd879b4c564a952c799219f23c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600560910$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600560910$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27911,27912,45561,45562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6049694$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Griffin, J.C.</creatorcontrib><creatorcontrib>Banker, G.S.</creatorcontrib><title>Reactions of amine drugs with sugars II Synthesis and in vivo evaluation of mannose amphetamine sulfonate and N-phenylisopropyl-d-mannamine</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Mannose amphetamine sulfonate was synthesized from the reaction of amphetamine bisulfite with D-mannose. N-Phenylisopropyl-D-mannamine was synthesized by catalytic hydrogenation of N-phenylisopropyl-D-mannosylamine. The products were evaluated in vivo by the Williamson activity cage method. Mannose amphetamine sulfonate was found to have a significantly longer duration of activity and produced a higher level of mean activity, from 3.5hr. to 4.5hr. after administration, than dextroamphetamine sulfate. N-Phenylisopropyl-D-mannamine was found to be orally inactive at dosage levels of 10 and 50 mg./Kg. of body weight.</description><subject>Amino Sugars - chemical synthesis</subject><subject>Amino Sugars - pharmacology</subject><subject>Animals</subject><subject>Dextroamphetamine</subject><subject>In Vitro Techniques</subject><subject>Mannose</subject><subject>Rats</subject><subject>Sulfonic Acids - chemical synthesis</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAURSMEKtPClh2SV-wyOI7txEs0gjKjqnwU1KXl2C8dl8Qe7GRKfkP_NJ5mVMQCsfLinnPld7PsVYGXBcbk7e0uLgnHmHEsCvwkWxSM4JzjonqaLRJA8pJR8Tw7jfEWY8wxYyfZCcdUcEEX2f1XUHqw3kXkW6R66wCZMN5EdGeHLYrjjQoRrdfoanLDFqKNSDmDrEN7u_cI9qob1cE_6L1yzkdINbstDHNZHLvWOzXAg3eZp8RNnY1-F_xu6nKTH6wH9kX2rFVdhJfH9yz7_uH9t9XH_OLT-Xr17iLXJU23kbJVvGoYlITh1lTc4EqUjTJU6YIALetCG92YuhIN1YxTJRjRlRCkEC0pdXmWvZl70xd-jhAH2duooeuUAz9GWVPGCMV1ApczqIOPMUArd8H2KkyywPKwvkzryz_rJ-H1sXlsejCP-HHulIs5v7MdTP9pk5vPV39157Nr4wC_Hl0VfkhelRWT15fn8nq1YRsiuPyS-HrmIU25txBk1BacBmMD6EEab_91xm8tarVX</recordid><startdate>196709</startdate><enddate>196709</enddate><creator>Griffin, J.C.</creator><creator>Banker, G.S.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196709</creationdate><title>Reactions of amine drugs with sugars II Synthesis and in vivo evaluation of mannose amphetamine sulfonate and N-phenylisopropyl-d-mannamine</title><author>Griffin, J.C. ; Banker, G.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3420-23fa67b5e3250fd76d0793bad4ac12e4381cdcbd879b4c564a952c799219f23c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Amino Sugars - chemical synthesis</topic><topic>Amino Sugars - pharmacology</topic><topic>Animals</topic><topic>Dextroamphetamine</topic><topic>In Vitro Techniques</topic><topic>Mannose</topic><topic>Rats</topic><topic>Sulfonic Acids - chemical synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Griffin, J.C.</creatorcontrib><creatorcontrib>Banker, G.S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Griffin, J.C.</au><au>Banker, G.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reactions of amine drugs with sugars II Synthesis and in vivo evaluation of mannose amphetamine sulfonate and N-phenylisopropyl-d-mannamine</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1967-09</date><risdate>1967</risdate><volume>56</volume><issue>9</issue><spage>1101</spage><epage>1103</epage><pages>1101-1103</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Mannose amphetamine sulfonate was synthesized from the reaction of amphetamine bisulfite with D-mannose. N-Phenylisopropyl-D-mannamine was synthesized by catalytic hydrogenation of N-phenylisopropyl-D-mannosylamine. The products were evaluated in vivo by the Williamson activity cage method. Mannose amphetamine sulfonate was found to have a significantly longer duration of activity and produced a higher level of mean activity, from 3.5hr. to 4.5hr. after administration, than dextroamphetamine sulfate. N-Phenylisopropyl-D-mannamine was found to be orally inactive at dosage levels of 10 and 50 mg./Kg. of body weight.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>6049694</pmid><doi>10.1002/jps.2600560910</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1967-09, Vol.56 (9), p.1101-1103 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84552408 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Amino Sugars - chemical synthesis Amino Sugars - pharmacology Animals Dextroamphetamine In Vitro Techniques Mannose Rats Sulfonic Acids - chemical synthesis |
| title | Reactions of amine drugs with sugars II Synthesis and in vivo evaluation of mannose amphetamine sulfonate and N-phenylisopropyl-d-mannamine |
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