Studies on 2-Benzimidazolethiol Derivatives. V : Structure-Activity Relationship on Analgesic Action of 1-(Dialkylaminoalkyl)-2-(p-ethoxyphenylthio)benzimidazole

1-(2-Diethylaminoethyl)-2-(p-ethoxyphenylthio)benzimidazole (I) is considered to be a morphine-like analgesic and its derivatives, 1-(diethylaminoalkyl)-2-(p-ethoxyphenylthio) benzimidazoles, were synthesized to test their analgesic effect by the pressure method. Except for the 1-(2-pyrrolidinoethyl...

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Veröffentlicht in:	YAKUGAKU ZASSHI 1967/03/25, Vol.87(3), pp.301-309
1. Verfasser:	Seki, Teruya
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	Analgesics - pharmacology Benzimidazoles - pharmacology Chemical Phenomena Chemistry Chromatography Spectrum Analysis
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description	1-(2-Diethylaminoethyl)-2-(p-ethoxyphenylthio)benzimidazole (I) is considered to be a morphine-like analgesic and its derivatives, 1-(diethylaminoalkyl)-2-(p-ethoxyphenylthio) benzimidazoles, were synthesized to test their analgesic effect by the pressure method. Except for the 1-(2-pyrrolidinoethyl)derivative showing better activities than I or morphine, other derivatives did not show much effect, such as 1-diethylaminomethyl, 3-diethylaminopropyl, 1-[2-(allylamino)ethyl], 1-(2-dialkylaminopropyl), and 1-(1-methyl-2-piperidinoethyl) derivatives. The allyl derivative did not show any antagonistic action against I or morphine. Some discussions were made on the central atom, basic nitrogen, and the flat aromatic portion in the molecules of I and its analogs.
doi_str_mv	10.1248/yakushi1947.87.3_301
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V : Structure-Activity Relationship on Analgesic Action of 1-(Dialkylaminoalkyl)-2-(p-ethoxyphenylthio)benzimidazole</atitle><jtitle>YAKUGAKU ZASSHI</jtitle><addtitle>YAKUGAKU ZASSHI</addtitle><date>1967-03</date><risdate>1967</risdate><volume>87</volume><issue>3</issue><spage>301</spage><epage>309</epage><pages>301-309</pages><issn>0031-6903</issn><eissn>1347-5231</eissn><abstract>1-(2-Diethylaminoethyl)-2-(p-ethoxyphenylthio)benzimidazole (I) is considered to be a morphine-like analgesic and its derivatives, 1-(diethylaminoalkyl)-2-(p-ethoxyphenylthio) benzimidazoles, were synthesized to test their analgesic effect by the pressure method. Except for the 1-(2-pyrrolidinoethyl)derivative showing better activities than I or morphine, other derivatives did not show much effect, such as 1-diethylaminomethyl, 3-diethylaminopropyl, 1-[2-(allylamino)ethyl], 1-(2-dialkylaminopropyl), and 1-(1-methyl-2-piperidinoethyl) derivatives. 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source	MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Alma/SFX Local Collection
subjects	Analgesics - pharmacology Benzimidazoles - pharmacology Chemical Phenomena Chemistry Chromatography Spectrum Analysis
title	Studies on 2-Benzimidazolethiol Derivatives. V : Structure-Activity Relationship on Analgesic Action of 1-(Dialkylaminoalkyl)-2-(p-ethoxyphenylthio)benzimidazole
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