Clinical significance of intraluminal pH in intestinal ammonia transport
1. 1. In the canine small intestine the ammonia furnished by the relatively alkaline ammonium acetate (pH 7.1) is absorbed at a faster rate than is ammonia from a comparable quantity of the relatively acid dibasic ammonium citrate (pH 4.8). 2. 2. In the canine and human colon ammonia can be dialyzed...
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| Veröffentlicht in: | The American journal of surgery 1970-05, Vol.119 (5), p.595-598 |
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| container_title | The American journal of surgery |
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| creator | Price, John B Sawada, Masashi Voorhees, Arthur B |
| description | 1.
1. In the canine small intestine the ammonia furnished by the relatively alkaline ammonium acetate (pH 7.1) is absorbed at a faster rate than is ammonia from a comparable quantity of the relatively acid dibasic ammonium citrate (pH 4.8).
2.
2. In the canine and human colon ammonia can be dialyzed more efficiently by an acid medium (Impersol) than by saline and much more efficiently than by an alkaline medium (THAM).
3.
3. Passive non-ionic diffusion appears to be the mechanism of ammonia transport in the colon and canine small bowel.
4.
4. Acid dialysis by Impersol in the acute situation or by lactulose for chronic use is suggested for the management of portasystemic encephalopathy. |
| doi_str_mv | 10.1016/0002-9610(70)90182-0 |
| format | Article |
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1. In the canine small intestine the ammonia furnished by the relatively alkaline ammonium acetate (pH 7.1) is absorbed at a faster rate than is ammonia from a comparable quantity of the relatively acid dibasic ammonium citrate (pH 4.8).
2.
2. In the canine and human colon ammonia can be dialyzed more efficiently by an acid medium (Impersol) than by saline and much more efficiently than by an alkaline medium (THAM).
3.
3. Passive non-ionic diffusion appears to be the mechanism of ammonia transport in the colon and canine small bowel.
4.
4. Acid dialysis by Impersol in the acute situation or by lactulose for chronic use is suggested for the management of portasystemic encephalopathy.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/0002-9610(70)90182-0</identifier><identifier>PMID: 5441753</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Ammonia - metabolism ; Animals ; Biological Transport ; Colon - metabolism ; Dogs ; Humans ; Hydrogen-Ion Concentration ; Intestinal Absorption ; Intestinal Mucosa - metabolism ; Intestine, Small - metabolism ; Liver Diseases - drug therapy ; Mental Disorders - drug therapy ; Nervous System Diseases - drug therapy ; Quaternary Ammonium Compounds - metabolism ; Tromethamine - administration & dosage</subject><ispartof>The American journal of surgery, 1970-05, Vol.119 (5), p.595-598</ispartof><rights>1970</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-e5ee76389f110556bef20f54761b54ab6e2fd9fe0188fe7204b157187097559b3</citedby><cites>FETCH-LOGICAL-c357t-e5ee76389f110556bef20f54761b54ab6e2fd9fe0188fe7204b157187097559b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9610(70)90182-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5441753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Price, John B</creatorcontrib><creatorcontrib>Sawada, Masashi</creatorcontrib><creatorcontrib>Voorhees, Arthur B</creatorcontrib><title>Clinical significance of intraluminal pH in intestinal ammonia transport</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>1.
1. In the canine small intestine the ammonia furnished by the relatively alkaline ammonium acetate (pH 7.1) is absorbed at a faster rate than is ammonia from a comparable quantity of the relatively acid dibasic ammonium citrate (pH 4.8).
2.
2. In the canine and human colon ammonia can be dialyzed more efficiently by an acid medium (Impersol) than by saline and much more efficiently than by an alkaline medium (THAM).
3.
3. Passive non-ionic diffusion appears to be the mechanism of ammonia transport in the colon and canine small bowel.
4.
4. Acid dialysis by Impersol in the acute situation or by lactulose for chronic use is suggested for the management of portasystemic encephalopathy.</description><subject>Ammonia - metabolism</subject><subject>Animals</subject><subject>Biological Transport</subject><subject>Colon - metabolism</subject><subject>Dogs</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Intestinal Absorption</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestine, Small - metabolism</subject><subject>Liver Diseases - drug therapy</subject><subject>Mental Disorders - drug therapy</subject><subject>Nervous System Diseases - drug therapy</subject><subject>Quaternary Ammonium Compounds - metabolism</subject><subject>Tromethamine - administration & dosage</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMo67r6DRR6Ej1UZ9qkaS-CLOoKC170HNJ2IpH-M-kKfnvT3WWPnpKZ92aS92PsEuEOAbN7AEjiIkO4kXBbAOZJDEdsjrksYszz9JjND5ZTdub9VygReTpjM8E5SpHO2WrZ2M5Wuom8_eysCdeuoqg3ke1Gp5tNa7sgDqtQTy3y47ah27bvrI6Cp_ND78ZzdmJ04-lify7Yx_PT-3IVr99eXpeP67hKhRxjEkQyS_PCIIIQWUkmASO4zLAUXJcZJaYuDIU4uSGZAC9RyJAJCilEUaYLdr3bO7j-exO-o1rrK2oa3VG_8SrnQmAismDkO2Pleu8dGTU422r3qxDUBFBNdNRER0lQW4AKwtjVfv-mbKk-DO2JBf1hp1MI-WPJKV9ZCsxq66gaVd3b_x_4AzHIfqQ</recordid><startdate>197005</startdate><enddate>197005</enddate><creator>Price, John B</creator><creator>Sawada, Masashi</creator><creator>Voorhees, Arthur B</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197005</creationdate><title>Clinical significance of intraluminal pH in intestinal ammonia transport</title><author>Price, John B ; Sawada, Masashi ; Voorhees, Arthur B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-e5ee76389f110556bef20f54761b54ab6e2fd9fe0188fe7204b157187097559b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Ammonia - metabolism</topic><topic>Animals</topic><topic>Biological Transport</topic><topic>Colon - metabolism</topic><topic>Dogs</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Intestinal Absorption</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestine, Small - metabolism</topic><topic>Liver Diseases - drug therapy</topic><topic>Mental Disorders - drug therapy</topic><topic>Nervous System Diseases - drug therapy</topic><topic>Quaternary Ammonium Compounds - metabolism</topic><topic>Tromethamine - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Price, John B</creatorcontrib><creatorcontrib>Sawada, Masashi</creatorcontrib><creatorcontrib>Voorhees, Arthur B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Price, John B</au><au>Sawada, Masashi</au><au>Voorhees, Arthur B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of intraluminal pH in intestinal ammonia transport</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>1970-05</date><risdate>1970</risdate><volume>119</volume><issue>5</issue><spage>595</spage><epage>598</epage><pages>595-598</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>1.
1. In the canine small intestine the ammonia furnished by the relatively alkaline ammonium acetate (pH 7.1) is absorbed at a faster rate than is ammonia from a comparable quantity of the relatively acid dibasic ammonium citrate (pH 4.8).
2.
2. In the canine and human colon ammonia can be dialyzed more efficiently by an acid medium (Impersol) than by saline and much more efficiently than by an alkaline medium (THAM).
3.
3. Passive non-ionic diffusion appears to be the mechanism of ammonia transport in the colon and canine small bowel.
4.
4. Acid dialysis by Impersol in the acute situation or by lactulose for chronic use is suggested for the management of portasystemic encephalopathy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>5441753</pmid><doi>10.1016/0002-9610(70)90182-0</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Ammonia - metabolism Animals Biological Transport Colon - metabolism Dogs Humans Hydrogen-Ion Concentration Intestinal Absorption Intestinal Mucosa - metabolism Intestine, Small - metabolism Liver Diseases - drug therapy Mental Disorders - drug therapy Nervous System Diseases - drug therapy Quaternary Ammonium Compounds - metabolism Tromethamine - administration & dosage |
| title | Clinical significance of intraluminal pH in intestinal ammonia transport |
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