Influence of Hydrocortisone Acetate on the Chemical Composition of Experimental Granulomas.
Summary Granulomas were induced by the bilateral implantation of weighed sterile cotton sponges in the dorsum of male Sherman rats. Hydrocortisone acetate (300 μg) impregnation significantly inhibited granuloma growth for approximately 5 days. In addition, steroid treatment significantly reduced the...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1967-08, Vol.125 (4), p.1297-1301 |
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| container_end_page | 1301 |
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| container_issue | 4 |
| container_start_page | 1297 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 125 |
| creator | Oronsky, A. L. Nocenti, M. R. |
| description | Summary
Granulomas were induced by the bilateral implantation of weighed sterile cotton sponges in the dorsum of male Sherman rats. Hydrocortisone acetate (300 μg) impregnation significantly inhibited granuloma growth for approximately 5 days. In addition, steroid treatment significantly reduced the total amount and concentration of collagen, total protein, DNA and RNA. Water content was increased by about 4% in the steroid treated granulomas. Hydrocortisone acetate (300 μg) impregnation resulted in significant reduction of both total C14-L-proline incorporation and specific activity (cpm/μg protein), measured at 12 and 24 hours after implantation. |
| doi_str_mv | 10.3181/00379727-125-32340 |
| format | Article |
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Granulomas were induced by the bilateral implantation of weighed sterile cotton sponges in the dorsum of male Sherman rats. Hydrocortisone acetate (300 μg) impregnation significantly inhibited granuloma growth for approximately 5 days. In addition, steroid treatment significantly reduced the total amount and concentration of collagen, total protein, DNA and RNA. Water content was increased by about 4% in the steroid treated granulomas. Hydrocortisone acetate (300 μg) impregnation resulted in significant reduction of both total C14-L-proline incorporation and specific activity (cpm/μg protein), measured at 12 and 24 hours after implantation.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-125-32340</identifier><identifier>PMID: 6042446</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Carbon Isotopes ; Collagen - metabolism ; DNA, Neoplasm - metabolism ; Granuloma - drug therapy ; Granuloma - metabolism ; Hydrocortisone - pharmacology ; Hydroxyproline - metabolism ; Male ; Neoplasm Proteins - metabolism ; Neoplasms, Experimental - drug therapy ; Neoplasms, Experimental - metabolism ; Proline - metabolism ; Rats ; RNA, Neoplasm - metabolism ; Water</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1967-08, Vol.125 (4), p.1297-1301</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-35e32b751b2b63b0312af71a6e0008ea3b2cbe41401d2378f7885072e186752e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6042446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oronsky, A. L.</creatorcontrib><creatorcontrib>Nocenti, M. R.</creatorcontrib><title>Influence of Hydrocortisone Acetate on the Chemical Composition of Experimental Granulomas.</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
Granulomas were induced by the bilateral implantation of weighed sterile cotton sponges in the dorsum of male Sherman rats. Hydrocortisone acetate (300 μg) impregnation significantly inhibited granuloma growth for approximately 5 days. In addition, steroid treatment significantly reduced the total amount and concentration of collagen, total protein, DNA and RNA. Water content was increased by about 4% in the steroid treated granulomas. Hydrocortisone acetate (300 μg) impregnation resulted in significant reduction of both total C14-L-proline incorporation and specific activity (cpm/μg protein), measured at 12 and 24 hours after implantation.</description><subject>Animals</subject><subject>Carbon Isotopes</subject><subject>Collagen - metabolism</subject><subject>DNA, Neoplasm - metabolism</subject><subject>Granuloma - drug therapy</subject><subject>Granuloma - metabolism</subject><subject>Hydrocortisone - pharmacology</subject><subject>Hydroxyproline - metabolism</subject><subject>Male</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Neoplasms, Experimental - drug therapy</subject><subject>Neoplasms, Experimental - metabolism</subject><subject>Proline - metabolism</subject><subject>Rats</subject><subject>RNA, Neoplasm - metabolism</subject><subject>Water</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LwzAchoMoc06_gCD05K1b_rXJjqPMbTDwoicPIe1-dR1tUpMU9NubuenRUwjP-74kD0L3BE8ZkWSGMRNzQUVKaJYyyji-QGOSsXjJ5_NLND4G0mPiGt14f8CYZILmIzTKMaec52P0tjF1O4CpILF1sv7aOVtZFxpvDSSLCoIOkZgk7CEp9tA1lW6Twna99U1oIoit5WcPrunAhMhWTpuhtZ3201t0VevWw935nKDXp-VLsU63z6tNsdimFWMypCwDRkuRkZKWOSsxI1TXgugcMMYSNCtpVQInHJMdZULWQsoMCwpE5iKjwCbo8bTbO_sxgA-qa3wFbasN2MEryTPOpcQxSE_BylnvHdSqj-_W7ksRrI5G1a9RFY2qH6Ox9HBeH8oOdn-Vs8LIZyfu9Tuogx2ciZ_9b_EbiLd-BA</recordid><startdate>196708</startdate><enddate>196708</enddate><creator>Oronsky, A. L.</creator><creator>Nocenti, M. R.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196708</creationdate><title>Influence of Hydrocortisone Acetate on the Chemical Composition of Experimental Granulomas.</title><author>Oronsky, A. L. ; Nocenti, M. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-35e32b751b2b63b0312af71a6e0008ea3b2cbe41401d2378f7885072e186752e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Animals</topic><topic>Carbon Isotopes</topic><topic>Collagen - metabolism</topic><topic>DNA, Neoplasm - metabolism</topic><topic>Granuloma - drug therapy</topic><topic>Granuloma - metabolism</topic><topic>Hydrocortisone - pharmacology</topic><topic>Hydroxyproline - metabolism</topic><topic>Male</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Neoplasms, Experimental - drug therapy</topic><topic>Neoplasms, Experimental - metabolism</topic><topic>Proline - metabolism</topic><topic>Rats</topic><topic>RNA, Neoplasm - metabolism</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oronsky, A. L.</creatorcontrib><creatorcontrib>Nocenti, M. R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oronsky, A. L.</au><au>Nocenti, M. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Hydrocortisone Acetate on the Chemical Composition of Experimental Granulomas.</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1967-08</date><risdate>1967</risdate><volume>125</volume><issue>4</issue><spage>1297</spage><epage>1301</epage><pages>1297-1301</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
Granulomas were induced by the bilateral implantation of weighed sterile cotton sponges in the dorsum of male Sherman rats. Hydrocortisone acetate (300 μg) impregnation significantly inhibited granuloma growth for approximately 5 days. In addition, steroid treatment significantly reduced the total amount and concentration of collagen, total protein, DNA and RNA. Water content was increased by about 4% in the steroid treated granulomas. Hydrocortisone acetate (300 μg) impregnation resulted in significant reduction of both total C14-L-proline incorporation and specific activity (cpm/μg protein), measured at 12 and 24 hours after implantation.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>6042446</pmid><doi>10.3181/00379727-125-32340</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1967-08, Vol.125 (4), p.1297-1301 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Carbon Isotopes Collagen - metabolism DNA, Neoplasm - metabolism Granuloma - drug therapy Granuloma - metabolism Hydrocortisone - pharmacology Hydroxyproline - metabolism Male Neoplasm Proteins - metabolism Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Proline - metabolism Rats RNA, Neoplasm - metabolism Water |
| title | Influence of Hydrocortisone Acetate on the Chemical Composition of Experimental Granulomas. |
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