Polymorphism Ala54Thr of Fatty Acid-Binding Protein 2: Allelic Frequencies and Influence on Cardiovascular Risk Factors in a Multicenter Study of Castilla y Leon
Background: A transition of guanin to alanin at codon 54 of the fatty acid-binding protein 2 gene (FABP2) results in an amino acid substitution (Ala54 to Thr54). This polymorphism was associated with some cardiovascular risk factors. Objective: The aim of our study was to investigate the influence o...
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| Veröffentlicht in: | Annals of nutrition and metabolism 2011-01, Vol.57 (3/4), p.163-168 |
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| creator | de Luis, D.A. Ballesteros, M. Ruiz, E. Cordero, M. Muñoz, C. Penacho, M.A. Iglesias, P. Guzman, A. Lopez Maldonado, A. Martin, L. San Puigdevall, V. Romero, E. Sagrado, M. Gonzalez Izaola, O. Conde, R. |
| description | Background: A transition of guanin to alanin at codon 54 of the fatty acid-binding protein 2 gene (FABP2) results in an amino acid substitution (Ala54 to Thr54). This polymorphism was associated with some cardiovascular risk factors. Objective: The aim of our study was to investigate the influence of the Thr54 polymorphism in the FABP2 gene on obesity anthropometric parameters and cardiovascular risk factors in the fasted state in obese subjects and the allelic distribution of this polymorphism in a geographic area of Spain. Design: A population of 264 obese subjects was analyzed in a cross-sectional study from all health centers of Castilla y Leon (Spain). A nutritional and biochemical evaluation was performed. The statistical analysis was performed for the combined Ala54/Thr54 and Thr54/Thr54 genotype as a dominant model. Results: The mean age was 41.1 ± 13.1 years and the mean BMI 36.5 ± 5.9, with 94 males (35.6%) and 170 females (74.4%). One hundred and fifty-three subjects (58%) had the genotype Ala54/Ala54 (wild-type group) and 111 (42%) participants had the genotype Ala54/Thr54 (n = 92, 34.8%) or Thr54/Thr54 (n = 19, 7.2%) (mutant-type group). The health area of Valladolid had a lower frequency of wild-type genotype and Ala54 allelic frequency than all the other health areas of Castilla y Leon. C-reactive protein was higher in the mutant-type than the wild-type group (3.4 ± 5.6 vs. 7.9 ± 10.4 mg/dl; p < 0.05). Conclusion: The finding of this study is the association of the Thr54/Ala54 and Thr54/Thr54 FABP2 phenotypes with higher levels of C-reactive protein without relation to insulin resistance. Frequencies of this polymorphism are different among health areas of Castilla y Leon. |
| doi_str_mv | 10.1159/000321632 |
| format | Article |
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Lopez ; Maldonado, A. ; Martin, L. San ; Puigdevall, V. ; Romero, E. ; Sagrado, M. Gonzalez ; Izaola, O. ; Conde, R.</creator><creatorcontrib>de Luis, D.A. ; Ballesteros, M. ; Ruiz, E. ; Cordero, M. ; Muñoz, C. ; Penacho, M.A. ; Iglesias, P. ; Guzman, A. Lopez ; Maldonado, A. ; Martin, L. San ; Puigdevall, V. ; Romero, E. ; Sagrado, M. Gonzalez ; Izaola, O. ; Conde, R.</creatorcontrib><description>Background: A transition of guanin to alanin at codon 54 of the fatty acid-binding protein 2 gene (FABP2) results in an amino acid substitution (Ala54 to Thr54). This polymorphism was associated with some cardiovascular risk factors. Objective: The aim of our study was to investigate the influence of the Thr54 polymorphism in the FABP2 gene on obesity anthropometric parameters and cardiovascular risk factors in the fasted state in obese subjects and the allelic distribution of this polymorphism in a geographic area of Spain. Design: A population of 264 obese subjects was analyzed in a cross-sectional study from all health centers of Castilla y Leon (Spain). A nutritional and biochemical evaluation was performed. The statistical analysis was performed for the combined Ala54/Thr54 and Thr54/Thr54 genotype as a dominant model. Results: The mean age was 41.1 ± 13.1 years and the mean BMI 36.5 ± 5.9, with 94 males (35.6%) and 170 females (74.4%). One hundred and fifty-three subjects (58%) had the genotype Ala54/Ala54 (wild-type group) and 111 (42%) participants had the genotype Ala54/Thr54 (n = 92, 34.8%) or Thr54/Thr54 (n = 19, 7.2%) (mutant-type group). The health area of Valladolid had a lower frequency of wild-type genotype and Ala54 allelic frequency than all the other health areas of Castilla y Leon. C-reactive protein was higher in the mutant-type than the wild-type group (3.4 ± 5.6 vs. 7.9 ± 10.4 mg/dl; p < 0.05). Conclusion: The finding of this study is the association of the Thr54/Ala54 and Thr54/Thr54 FABP2 phenotypes with higher levels of C-reactive protein without relation to insulin resistance. Frequencies of this polymorphism are different among health areas of Castilla y Leon.</description><identifier>ISSN: 0250-6807</identifier><identifier>EISSN: 1421-9697</identifier><identifier>DOI: 10.1159/000321632</identifier><identifier>PMID: 21079390</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Alanine - genetics ; Alanine - metabolism ; Amino acids ; Anthropometry ; Body Mass Index ; C-Reactive Protein - analysis ; C-Reactive Protein - metabolism ; Cardiovascular disease ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - genetics ; Cross-Sectional Studies ; Fatty Acid-Binding Proteins - genetics ; Fatty acids ; Female ; Gene Frequency ; Genes ; Genetic Predisposition to Disease ; Genotype ; Health risks ; Humans ; Insulin Resistance - genetics ; Insulin Resistance - physiology ; Male ; Mutation ; Obesity ; Obesity - blood ; Obesity - complications ; Obesity - genetics ; Original Paper ; Phenotype ; Polymorphism ; Polymorphism, Genetic ; Risk Factors ; Spain ; Statistical analysis ; Threonine - genetics ; Threonine - metabolism</subject><ispartof>Annals of nutrition and metabolism, 2011-01, Vol.57 (3/4), p.163-168</ispartof><rights>2010 S. Karger AG</rights><rights>2010 S. Karger AG, Basel</rights><rights>Copyright © 2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-ea4307a1b44da470e7cc3f56720343899a7d72322ba59b31d8d48e79a869d5a13</citedby><cites>FETCH-LOGICAL-c354t-ea4307a1b44da470e7cc3f56720343899a7d72322ba59b31d8d48e79a869d5a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/48514065$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/48514065$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2422,27903,27904,57996,58229</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21079390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Luis, D.A.</creatorcontrib><creatorcontrib>Ballesteros, M.</creatorcontrib><creatorcontrib>Ruiz, E.</creatorcontrib><creatorcontrib>Cordero, M.</creatorcontrib><creatorcontrib>Muñoz, C.</creatorcontrib><creatorcontrib>Penacho, M.A.</creatorcontrib><creatorcontrib>Iglesias, P.</creatorcontrib><creatorcontrib>Guzman, A. Lopez</creatorcontrib><creatorcontrib>Maldonado, A.</creatorcontrib><creatorcontrib>Martin, L. San</creatorcontrib><creatorcontrib>Puigdevall, V.</creatorcontrib><creatorcontrib>Romero, E.</creatorcontrib><creatorcontrib>Sagrado, M. Gonzalez</creatorcontrib><creatorcontrib>Izaola, O.</creatorcontrib><creatorcontrib>Conde, R.</creatorcontrib><title>Polymorphism Ala54Thr of Fatty Acid-Binding Protein 2: Allelic Frequencies and Influence on Cardiovascular Risk Factors in a Multicenter Study of Castilla y Leon</title><title>Annals of nutrition and metabolism</title><addtitle>Ann Nutr Metab</addtitle><description>Background: A transition of guanin to alanin at codon 54 of the fatty acid-binding protein 2 gene (FABP2) results in an amino acid substitution (Ala54 to Thr54). This polymorphism was associated with some cardiovascular risk factors. Objective: The aim of our study was to investigate the influence of the Thr54 polymorphism in the FABP2 gene on obesity anthropometric parameters and cardiovascular risk factors in the fasted state in obese subjects and the allelic distribution of this polymorphism in a geographic area of Spain. Design: A population of 264 obese subjects was analyzed in a cross-sectional study from all health centers of Castilla y Leon (Spain). A nutritional and biochemical evaluation was performed. The statistical analysis was performed for the combined Ala54/Thr54 and Thr54/Thr54 genotype as a dominant model. Results: The mean age was 41.1 ± 13.1 years and the mean BMI 36.5 ± 5.9, with 94 males (35.6%) and 170 females (74.4%). One hundred and fifty-three subjects (58%) had the genotype Ala54/Ala54 (wild-type group) and 111 (42%) participants had the genotype Ala54/Thr54 (n = 92, 34.8%) or Thr54/Thr54 (n = 19, 7.2%) (mutant-type group). The health area of Valladolid had a lower frequency of wild-type genotype and Ala54 allelic frequency than all the other health areas of Castilla y Leon. C-reactive protein was higher in the mutant-type than the wild-type group (3.4 ± 5.6 vs. 7.9 ± 10.4 mg/dl; p < 0.05). Conclusion: The finding of this study is the association of the Thr54/Ala54 and Thr54/Thr54 FABP2 phenotypes with higher levels of C-reactive protein without relation to insulin resistance. Frequencies of this polymorphism are different among health areas of Castilla y Leon.</description><subject>Adult</subject><subject>Alanine - genetics</subject><subject>Alanine - metabolism</subject><subject>Amino acids</subject><subject>Anthropometry</subject><subject>Body Mass Index</subject><subject>C-Reactive Protein - analysis</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Cross-Sectional Studies</subject><subject>Fatty Acid-Binding Proteins - genetics</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Health risks</subject><subject>Humans</subject><subject>Insulin Resistance - genetics</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Mutation</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Obesity - genetics</subject><subject>Original Paper</subject><subject>Phenotype</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><subject>Spain</subject><subject>Statistical analysis</subject><subject>Threonine - genetics</subject><subject>Threonine - metabolism</subject><issn>0250-6807</issn><issn>1421-9697</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpd0D1PwzAQBmALgWgpDOyAIhbEEPBnbI-looBUiQ5ljpzYaVOSuNjJ0H-PUUqQmG645053LwCXCD4gxOQjhJBglBB8BMaIYhTLRPJjMIaYwTgRkI_AmfdbCBEWlJ2CEUaQSyLhGLClrfa1dbtN6etoWilGVxsX2SKaq7bdR9O81PFT2eiyWUdLZ1tTNhE-ByeFqry5ONQJ-Jg_r2av8eL95W02XcQ5YbSNjaIEcoUySrWiHBqe56RgCceQUCKkVFxzTDDOFJMZQVpoKgyXSiRSM4XIBNz1e3fOfnXGt2ld-txUlWqM7XwaviGSsQQHeftPbm3nmnBcQELiEA4L6L5HubPeO1OkO1fWyu1TBNOfJNMhyWBvDgu7rDZ6kL_RBXDVg0_l1sYNYJi_7ttb39q_LhUMUZgw8g1vSnxS</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>de Luis, D.A.</creator><creator>Ballesteros, M.</creator><creator>Ruiz, E.</creator><creator>Cordero, M.</creator><creator>Muñoz, C.</creator><creator>Penacho, M.A.</creator><creator>Iglesias, P.</creator><creator>Guzman, A. 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Lopez ; Maldonado, A. ; Martin, L. San ; Puigdevall, V. ; Romero, E. ; Sagrado, M. 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Gonzalez</creatorcontrib><creatorcontrib>Izaola, O.</creatorcontrib><creatorcontrib>Conde, R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of nutrition and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Luis, D.A.</au><au>Ballesteros, M.</au><au>Ruiz, E.</au><au>Cordero, M.</au><au>Muñoz, C.</au><au>Penacho, M.A.</au><au>Iglesias, P.</au><au>Guzman, A. Lopez</au><au>Maldonado, A.</au><au>Martin, L. San</au><au>Puigdevall, V.</au><au>Romero, E.</au><au>Sagrado, M. Gonzalez</au><au>Izaola, O.</au><au>Conde, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphism Ala54Thr of Fatty Acid-Binding Protein 2: Allelic Frequencies and Influence on Cardiovascular Risk Factors in a Multicenter Study of Castilla y Leon</atitle><jtitle>Annals of nutrition and metabolism</jtitle><addtitle>Ann Nutr Metab</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>57</volume><issue>3/4</issue><spage>163</spage><epage>168</epage><pages>163-168</pages><issn>0250-6807</issn><eissn>1421-9697</eissn><abstract>Background: A transition of guanin to alanin at codon 54 of the fatty acid-binding protein 2 gene (FABP2) results in an amino acid substitution (Ala54 to Thr54). This polymorphism was associated with some cardiovascular risk factors. Objective: The aim of our study was to investigate the influence of the Thr54 polymorphism in the FABP2 gene on obesity anthropometric parameters and cardiovascular risk factors in the fasted state in obese subjects and the allelic distribution of this polymorphism in a geographic area of Spain. Design: A population of 264 obese subjects was analyzed in a cross-sectional study from all health centers of Castilla y Leon (Spain). A nutritional and biochemical evaluation was performed. The statistical analysis was performed for the combined Ala54/Thr54 and Thr54/Thr54 genotype as a dominant model. Results: The mean age was 41.1 ± 13.1 years and the mean BMI 36.5 ± 5.9, with 94 males (35.6%) and 170 females (74.4%). One hundred and fifty-three subjects (58%) had the genotype Ala54/Ala54 (wild-type group) and 111 (42%) participants had the genotype Ala54/Thr54 (n = 92, 34.8%) or Thr54/Thr54 (n = 19, 7.2%) (mutant-type group). The health area of Valladolid had a lower frequency of wild-type genotype and Ala54 allelic frequency than all the other health areas of Castilla y Leon. C-reactive protein was higher in the mutant-type than the wild-type group (3.4 ± 5.6 vs. 7.9 ± 10.4 mg/dl; p < 0.05). Conclusion: The finding of this study is the association of the Thr54/Ala54 and Thr54/Thr54 FABP2 phenotypes with higher levels of C-reactive protein without relation to insulin resistance. Frequencies of this polymorphism are different among health areas of Castilla y Leon.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>21079390</pmid><doi>10.1159/000321632</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0250-6807 |
| ispartof | Annals of nutrition and metabolism, 2011-01, Vol.57 (3/4), p.163-168 |
| issn | 0250-6807 1421-9697 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_845395562 |
| source | MEDLINE; Jstor Complete Legacy; Karger Journals; Alma/SFX Local Collection |
| subjects | Adult Alanine - genetics Alanine - metabolism Amino acids Anthropometry Body Mass Index C-Reactive Protein - analysis C-Reactive Protein - metabolism Cardiovascular disease Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Cardiovascular Diseases - genetics Cross-Sectional Studies Fatty Acid-Binding Proteins - genetics Fatty acids Female Gene Frequency Genes Genetic Predisposition to Disease Genotype Health risks Humans Insulin Resistance - genetics Insulin Resistance - physiology Male Mutation Obesity Obesity - blood Obesity - complications Obesity - genetics Original Paper Phenotype Polymorphism Polymorphism, Genetic Risk Factors Spain Statistical analysis Threonine - genetics Threonine - metabolism |
| title | Polymorphism Ala54Thr of Fatty Acid-Binding Protein 2: Allelic Frequencies and Influence on Cardiovascular Risk Factors in a Multicenter Study of Castilla y Leon |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T19%3A26%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Polymorphism%20Ala54Thr%20of%20Fatty%20Acid-Binding%20Protein%202:%20Allelic%20Frequencies%20and%20Influence%20on%20Cardiovascular%20Risk%20Factors%20in%20a%20Multicenter%20Study%20of%20Castilla%20y%20Leon&rft.jtitle=Annals%20of%20nutrition%20and%20metabolism&rft.au=de%20Luis,%20D.A.&rft.date=2011-01-01&rft.volume=57&rft.issue=3/4&rft.spage=163&rft.epage=168&rft.pages=163-168&rft.issn=0250-6807&rft.eissn=1421-9697&rft_id=info:doi/10.1159/000321632&rft_dat=%3Cjstor_proqu%3E48514065%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=848926325&rft_id=info:pmid/21079390&rft_jstor_id=48514065&rfr_iscdi=true |