Antiviral Activity of Double Stranded RNA from a Virus isolated from Aspergillus foetidus
IN recent years virus particles with the property of inducing interferon production in animals have been isolated from Penicillium stoloniferum 1,2 , P. funiculosum 2 and P. cyaneofulvum 3 . Virus particles have also been isolated from penicillin producing strains of P. chrysogenum 4 and we have sho...
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| Veröffentlicht in: | Nature (London) 1970-08, Vol.227 (5257), p.505-507 |
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| creator | BANKS, G. T. BUCK, K. W. CHAIN, E. B. DARBYSHIRE, JOAN E. HIMMELWEIT, F. RATTI, G. SHARPE, T. J. PLANTEROSE, D. N. |
| description | IN recent years virus particles with the property of inducing interferon production in animals have been isolated from
Penicillium stoloniferum
1,2
,
P. funiculosum
2
and
P. cyaneofulvum
3
. Virus particles have also been isolated from penicillin producing strains of
P. chrysogenum
4
and we have shown that both the particles and derived double stranded RNA are active interferon inducers in animals (unpublished results). Following the observation
5
that a high level of cell wall galactosamine seemed to be associated with the presence of virus particles in
P. stoloniferum
, we have examined a number of fungi, reported to contain cell wall galactosamine, for possible virus content. One of those examined,
Aspergillus niger
(strain IMI 146891)
ast;
, was found to contain polyhedral virus particles; similar particles were also found in a closely related species,
A. foetidus
(strain IMI 41871). This is the first report of virus particles in the genus
Aspergillus
. We now describe the isolation and purification of the
A. foetidus
virus and provide evidence that the RNA isolated from the virus particles is double stranded. We have found that both virus particles and double stranded RNA are active in inducing interferon production and protecting mice against encephalomyocarditis and Semliki Forest viruses. |
| doi_str_mv | 10.1038/227505a0 |
| format | Article |
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Penicillium stoloniferum
1,2
,
P. funiculosum
2
and
P. cyaneofulvum
3
. Virus particles have also been isolated from penicillin producing strains of
P. chrysogenum
4
and we have shown that both the particles and derived double stranded RNA are active interferon inducers in animals (unpublished results). Following the observation
5
that a high level of cell wall galactosamine seemed to be associated with the presence of virus particles in
P. stoloniferum
, we have examined a number of fungi, reported to contain cell wall galactosamine, for possible virus content. One of those examined,
Aspergillus niger
(strain IMI 146891)
ast;
, was found to contain polyhedral virus particles; similar particles were also found in a closely related species,
A. foetidus
(strain IMI 41871). This is the first report of virus particles in the genus
Aspergillus
. We now describe the isolation and purification of the
A. foetidus
virus and provide evidence that the RNA isolated from the virus particles is double stranded. We have found that both virus particles and double stranded RNA are active in inducing interferon production and protecting mice against encephalomyocarditis and Semliki Forest viruses.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/227505a0</identifier><identifier>PMID: 4316959</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Aspergillus ; Centrifugation, Density Gradient ; Electrophoresis, Disc ; Encephalitis - drug therapy ; Encephalomyocarditis virus - drug effects ; Hot Temperature ; Humanities and Social Sciences ; Interferons - biosynthesis ; letter ; Mice ; Microscopy, Electron ; multidisciplinary ; Myocarditis - drug therapy ; Nucleic Acid Denaturation ; Ribonucleases ; RNA Viruses ; RNA, Viral - pharmacology ; Science ; Science (multidisciplinary) ; Semliki forest virus - drug effects</subject><ispartof>Nature (London), 1970-08, Vol.227 (5257), p.505-507</ispartof><rights>Springer Nature Limited 1970</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c312t-8dbaf0008ee701ab9e8e1ea7af648969ab739ff751e7d50db6e9ccd3a1a4d0743</citedby><cites>FETCH-LOGICAL-c312t-8dbaf0008ee701ab9e8e1ea7af648969ab739ff751e7d50db6e9ccd3a1a4d0743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/227505a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/227505a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4316959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BANKS, G. T.</creatorcontrib><creatorcontrib>BUCK, K. W.</creatorcontrib><creatorcontrib>CHAIN, E. B.</creatorcontrib><creatorcontrib>DARBYSHIRE, JOAN E.</creatorcontrib><creatorcontrib>HIMMELWEIT, F.</creatorcontrib><creatorcontrib>RATTI, G.</creatorcontrib><creatorcontrib>SHARPE, T. J.</creatorcontrib><creatorcontrib>PLANTEROSE, D. N.</creatorcontrib><title>Antiviral Activity of Double Stranded RNA from a Virus isolated from Aspergillus foetidus</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>IN recent years virus particles with the property of inducing interferon production in animals have been isolated from
Penicillium stoloniferum
1,2
,
P. funiculosum
2
and
P. cyaneofulvum
3
. Virus particles have also been isolated from penicillin producing strains of
P. chrysogenum
4
and we have shown that both the particles and derived double stranded RNA are active interferon inducers in animals (unpublished results). Following the observation
5
that a high level of cell wall galactosamine seemed to be associated with the presence of virus particles in
P. stoloniferum
, we have examined a number of fungi, reported to contain cell wall galactosamine, for possible virus content. One of those examined,
Aspergillus niger
(strain IMI 146891)
ast;
, was found to contain polyhedral virus particles; similar particles were also found in a closely related species,
A. foetidus
(strain IMI 41871). This is the first report of virus particles in the genus
Aspergillus
. We now describe the isolation and purification of the
A. foetidus
virus and provide evidence that the RNA isolated from the virus particles is double stranded. We have found that both virus particles and double stranded RNA are active in inducing interferon production and protecting mice against encephalomyocarditis and Semliki Forest viruses.</description><subject>Animals</subject><subject>Aspergillus</subject><subject>Centrifugation, Density Gradient</subject><subject>Electrophoresis, Disc</subject><subject>Encephalitis - drug therapy</subject><subject>Encephalomyocarditis virus - drug effects</subject><subject>Hot Temperature</subject><subject>Humanities and Social Sciences</subject><subject>Interferons - biosynthesis</subject><subject>letter</subject><subject>Mice</subject><subject>Microscopy, Electron</subject><subject>multidisciplinary</subject><subject>Myocarditis - drug therapy</subject><subject>Nucleic Acid Denaturation</subject><subject>Ribonucleases</subject><subject>RNA Viruses</subject><subject>RNA, Viral - pharmacology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Semliki forest virus - drug effects</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkF1LwzAUhoMoc07BPyDkSvSimjTNRy_L_ARR8Au8KmlzMjq6ZiatsH9v5qY3XuWQ5-HlnBehY0ouKGHqMk0lJ1yTHTSmmRRJJpTcRWNCUpUQxcQ-OghhTgjhVGYjNMoYFTnPx-ij6Prmq_G6xUW9nvoVdhZfuaFqAb_0XncGDH5-LLD1boE1fm_8EHATXKv7SH5-i7AEP2vaNhLroG_MEA7RntVtgKPtO0FvN9ev07vk4en2flo8JDWjaZ8oU2kbF1MAklBd5aCAgpbaikzlIteVZLm1klOQhhNTCcjr2jBNdWaIzNgEnW5yl959DhD6ctGEGtpWd-CGUKqMM6W4iOLZRqy9C8GDLZe-WWi_Kikp1y2Wvy1G9WSbOVQLMH_itrbIzzc8RNLNwJdzN_gunvk_6xu5AHpm</recordid><startdate>19700801</startdate><enddate>19700801</enddate><creator>BANKS, G. T.</creator><creator>BUCK, K. W.</creator><creator>CHAIN, E. B.</creator><creator>DARBYSHIRE, JOAN E.</creator><creator>HIMMELWEIT, F.</creator><creator>RATTI, G.</creator><creator>SHARPE, T. J.</creator><creator>PLANTEROSE, D. N.</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19700801</creationdate><title>Antiviral Activity of Double Stranded RNA from a Virus isolated from Aspergillus foetidus</title><author>BANKS, G. T. ; BUCK, K. W. ; CHAIN, E. B. ; DARBYSHIRE, JOAN E. ; HIMMELWEIT, F. ; RATTI, G. ; SHARPE, T. J. ; PLANTEROSE, D. 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T.</creatorcontrib><creatorcontrib>BUCK, K. W.</creatorcontrib><creatorcontrib>CHAIN, E. B.</creatorcontrib><creatorcontrib>DARBYSHIRE, JOAN E.</creatorcontrib><creatorcontrib>HIMMELWEIT, F.</creatorcontrib><creatorcontrib>RATTI, G.</creatorcontrib><creatorcontrib>SHARPE, T. J.</creatorcontrib><creatorcontrib>PLANTEROSE, D. N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BANKS, G. T.</au><au>BUCK, K. W.</au><au>CHAIN, E. B.</au><au>DARBYSHIRE, JOAN E.</au><au>HIMMELWEIT, F.</au><au>RATTI, G.</au><au>SHARPE, T. J.</au><au>PLANTEROSE, D. N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiviral Activity of Double Stranded RNA from a Virus isolated from Aspergillus foetidus</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1970-08-01</date><risdate>1970</risdate><volume>227</volume><issue>5257</issue><spage>505</spage><epage>507</epage><pages>505-507</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>IN recent years virus particles with the property of inducing interferon production in animals have been isolated from
Penicillium stoloniferum
1,2
,
P. funiculosum
2
and
P. cyaneofulvum
3
. Virus particles have also been isolated from penicillin producing strains of
P. chrysogenum
4
and we have shown that both the particles and derived double stranded RNA are active interferon inducers in animals (unpublished results). Following the observation
5
that a high level of cell wall galactosamine seemed to be associated with the presence of virus particles in
P. stoloniferum
, we have examined a number of fungi, reported to contain cell wall galactosamine, for possible virus content. One of those examined,
Aspergillus niger
(strain IMI 146891)
ast;
, was found to contain polyhedral virus particles; similar particles were also found in a closely related species,
A. foetidus
(strain IMI 41871). This is the first report of virus particles in the genus
Aspergillus
. We now describe the isolation and purification of the
A. foetidus
virus and provide evidence that the RNA isolated from the virus particles is double stranded. We have found that both virus particles and double stranded RNA are active in inducing interferon production and protecting mice against encephalomyocarditis and Semliki Forest viruses.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>4316959</pmid><doi>10.1038/227505a0</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Nature (London), 1970-08, Vol.227 (5257), p.505-507 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Animals Aspergillus Centrifugation, Density Gradient Electrophoresis, Disc Encephalitis - drug therapy Encephalomyocarditis virus - drug effects Hot Temperature Humanities and Social Sciences Interferons - biosynthesis letter Mice Microscopy, Electron multidisciplinary Myocarditis - drug therapy Nucleic Acid Denaturation Ribonucleases RNA Viruses RNA, Viral - pharmacology Science Science (multidisciplinary) Semliki forest virus - drug effects |
| title | Antiviral Activity of Double Stranded RNA from a Virus isolated from Aspergillus foetidus |
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