Prevention by Estrogen of the Decidual Alkaline Phosphatase Response in Intact and Ovariectomized Pseudopregnant Rats
Summary The decidual alkaline phosphatase of traumatized intact pseudopregnant rats was 10–15 times greater on day 8 than nondecidualized uteri. This effect was not altered by treatment of (a) intact rats with 5 mg of progesterone and/or 17β-estradiol, 0.1 μg on days 1–3, 1.0 μg on days 4–7, daily,...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1970-03, Vol.133 (3), p.1031-1034 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 133 |
| creator | Manning, John P. Calenti, Lali Carter, Shirley G. |
| description | Summary
The decidual alkaline phosphatase of traumatized intact pseudopregnant rats was 10–15 times greater on day 8 than nondecidualized uteri. This effect was not altered by treatment of (a) intact rats with 5 mg of progesterone and/or 17β-estradiol, 0.1 μg on days 1–3, 1.0 μg on days 4–7, daily, and (b) castrated animals with the progestin (days 1–7) alone or combined with either the above estrogen regimen, or a single 1.01 μg dose of 17β-estradiol on days 3, 4, or 5. If 1.0 μg of 17β-estradiol was administered with or without progesterone for days 1–7, no decidualization or rise in alkaline phosphatase was noted. Similarly, the enzyme failed to increase in nondecidualized castrated rats receiving the 0.1 μg on days 1–3, 1.0 μg on days 4–7, estrogen regimen. The data demonstrate that the decidual alkaline phosphatase response is independent of circulating ovarian estrogen.
Estrogen (0.1 μg on days 1–3 or 4, 1.0 μg on days 4 or 5–7) appeared to reduce the number of intact rats exhibiting decidualization and enhanced enzyme activity. |
| doi_str_mv | 10.3181/00379727-133-34620 |
| format | Article |
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The decidual alkaline phosphatase of traumatized intact pseudopregnant rats was 10–15 times greater on day 8 than nondecidualized uteri. This effect was not altered by treatment of (a) intact rats with 5 mg of progesterone and/or 17β-estradiol, 0.1 μg on days 1–3, 1.0 μg on days 4–7, daily, and (b) castrated animals with the progestin (days 1–7) alone or combined with either the above estrogen regimen, or a single 1.01 μg dose of 17β-estradiol on days 3, 4, or 5. If 1.0 μg of 17β-estradiol was administered with or without progesterone for days 1–7, no decidualization or rise in alkaline phosphatase was noted. Similarly, the enzyme failed to increase in nondecidualized castrated rats receiving the 0.1 μg on days 1–3, 1.0 μg on days 4–7, estrogen regimen. The data demonstrate that the decidual alkaline phosphatase response is independent of circulating ovarian estrogen.
Estrogen (0.1 μg on days 1–3 or 4, 1.0 μg on days 4 or 5–7) appeared to reduce the number of intact rats exhibiting decidualization and enhanced enzyme activity.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-133-34620</identifier><identifier>PMID: 5435559</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Alkaline Phosphatase - metabolism ; Animals ; Castration ; Decidua - enzymology ; Electric Stimulation ; Estradiol - therapeutic use ; Estrogens - blood ; Female ; Pregnancy ; Progesterone - pharmacology ; Pseudopregnancy ; Rats</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1970-03, Vol.133 (3), p.1031-1034</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5435559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manning, John P.</creatorcontrib><creatorcontrib>Calenti, Lali</creatorcontrib><creatorcontrib>Carter, Shirley G.</creatorcontrib><title>Prevention by Estrogen of the Decidual Alkaline Phosphatase Response in Intact and Ovariectomized Pseudopregnant Rats</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
The decidual alkaline phosphatase of traumatized intact pseudopregnant rats was 10–15 times greater on day 8 than nondecidualized uteri. This effect was not altered by treatment of (a) intact rats with 5 mg of progesterone and/or 17β-estradiol, 0.1 μg on days 1–3, 1.0 μg on days 4–7, daily, and (b) castrated animals with the progestin (days 1–7) alone or combined with either the above estrogen regimen, or a single 1.01 μg dose of 17β-estradiol on days 3, 4, or 5. If 1.0 μg of 17β-estradiol was administered with or without progesterone for days 1–7, no decidualization or rise in alkaline phosphatase was noted. Similarly, the enzyme failed to increase in nondecidualized castrated rats receiving the 0.1 μg on days 1–3, 1.0 μg on days 4–7, estrogen regimen. The data demonstrate that the decidual alkaline phosphatase response is independent of circulating ovarian estrogen.
Estrogen (0.1 μg on days 1–3 or 4, 1.0 μg on days 4 or 5–7) appeared to reduce the number of intact rats exhibiting decidualization and enhanced enzyme activity.</description><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>Castration</subject><subject>Decidua - enzymology</subject><subject>Electric Stimulation</subject><subject>Estradiol - therapeutic use</subject><subject>Estrogens - blood</subject><subject>Female</subject><subject>Pregnancy</subject><subject>Progesterone - pharmacology</subject><subject>Pseudopregnancy</subject><subject>Rats</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhi1EBVvgD1RC8olbwJ9xckRACxISK9SerUk82Q3N2sF2kODXN8tue-xpRprnfaV5CPnG2aXkFb9iTJraCFNwKQupSsEOyIJrqQtZ1vUhWWyBYksck68pvTDGtRHlETnSSmqt6wWZlhHf0Oc-eNq807uUY1ihp6GjeY30FtveTTDQ6-E3DL1HulyHNK4hQ0L6jGkMfl56Tx98hjZT8I4-vUHssc1h03-go8uEkwtjxJUHn-kz5HRKvnQwJDzbzxPy6_vdz5v74vHpx8PN9WPRiqrOhXSN4kaplpesKZXRTQmm6oTsnHBGy6qRteNg6oaB0kpwhyg0llg3wFAzeUIudr1jDK8Tpmw3fWpxGMBjmJKtlBZKaD2DYge2MaQUsbNj7DcQ3y1nduva_nVtZ9f20_UcOt-3T80G3b_IXu58v9rdE6zQvoQp-vnZ_zX-AUkMiME</recordid><startdate>197003</startdate><enddate>197003</enddate><creator>Manning, John P.</creator><creator>Calenti, Lali</creator><creator>Carter, Shirley G.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197003</creationdate><title>Prevention by Estrogen of the Decidual Alkaline Phosphatase Response in Intact and Ovariectomized Pseudopregnant Rats</title><author>Manning, John P. ; Calenti, Lali ; Carter, Shirley G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c289t-3db41744c160b6475b6a78f23fd2d7538b39d1a79b0a45421dee25e6e9ba0e503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>Castration</topic><topic>Decidua - enzymology</topic><topic>Electric Stimulation</topic><topic>Estradiol - therapeutic use</topic><topic>Estrogens - blood</topic><topic>Female</topic><topic>Pregnancy</topic><topic>Progesterone - pharmacology</topic><topic>Pseudopregnancy</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manning, John P.</creatorcontrib><creatorcontrib>Calenti, Lali</creatorcontrib><creatorcontrib>Carter, Shirley G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manning, John P.</au><au>Calenti, Lali</au><au>Carter, Shirley G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention by Estrogen of the Decidual Alkaline Phosphatase Response in Intact and Ovariectomized Pseudopregnant Rats</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1970-03</date><risdate>1970</risdate><volume>133</volume><issue>3</issue><spage>1031</spage><epage>1034</epage><pages>1031-1034</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
The decidual alkaline phosphatase of traumatized intact pseudopregnant rats was 10–15 times greater on day 8 than nondecidualized uteri. This effect was not altered by treatment of (a) intact rats with 5 mg of progesterone and/or 17β-estradiol, 0.1 μg on days 1–3, 1.0 μg on days 4–7, daily, and (b) castrated animals with the progestin (days 1–7) alone or combined with either the above estrogen regimen, or a single 1.01 μg dose of 17β-estradiol on days 3, 4, or 5. If 1.0 μg of 17β-estradiol was administered with or without progesterone for days 1–7, no decidualization or rise in alkaline phosphatase was noted. Similarly, the enzyme failed to increase in nondecidualized castrated rats receiving the 0.1 μg on days 1–3, 1.0 μg on days 4–7, estrogen regimen. The data demonstrate that the decidual alkaline phosphatase response is independent of circulating ovarian estrogen.
Estrogen (0.1 μg on days 1–3 or 4, 1.0 μg on days 4 or 5–7) appeared to reduce the number of intact rats exhibiting decidualization and enhanced enzyme activity.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>5435559</pmid><doi>10.3181/00379727-133-34620</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1970-03, Vol.133 (3), p.1031-1034 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84524255 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Alkaline Phosphatase - metabolism Animals Castration Decidua - enzymology Electric Stimulation Estradiol - therapeutic use Estrogens - blood Female Pregnancy Progesterone - pharmacology Pseudopregnancy Rats |
| title | Prevention by Estrogen of the Decidual Alkaline Phosphatase Response in Intact and Ovariectomized Pseudopregnant Rats |
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