A comparative study of drug metabolism in the isolated perfused liver and in vivo in rats

The plasma half-lives of five drugs, phenylbutazone, antipyrine, oxotremorine, nortriptyline and desmethylimipramine were compared in vivo and in the isolated perfused rat liver. All drugs showed first order elimination in the perfusion experiments over wide concentration ranges. The half-lives in v...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 1970, Vol.9 (1), p.99-105
Hauptverfasser:	Von Bahr, C., Alexanderson, B., Azarnoff, D.L., Sjöqvist, F., Orrenius, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipyrine Antipyrine - metabolism Desipramine - blood Desipramine - metabolism Desmethylimipramine Drug metabolism Enzyme Induction In Vitro Techniques Liver - metabolism Male Nortriptyline Nortriptyline - blood Nortriptyline - metabolism Oxotremorine Perfused rat liver Perfusion Phenobarbital - pharmacology Phenylbutazone Phenylbutazone - blood Phenylbutazone - metabolism Rats Tremorine - blood Tremorine - metabolism Volume of distribution
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!