A comparative study of drug metabolism in the isolated perfused liver and in vivo in rats
The plasma half-lives of five drugs, phenylbutazone, antipyrine, oxotremorine, nortriptyline and desmethylimipramine were compared in vivo and in the isolated perfused rat liver. All drugs showed first order elimination in the perfusion experiments over wide concentration ranges. The half-lives in v...
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| Veröffentlicht in: | European journal of pharmacology 1970, Vol.9 (1), p.99-105 |
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| container_title | European journal of pharmacology |
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| creator | Von Bahr, C. Alexanderson, B. Azarnoff, D.L. Sjöqvist, F. Orrenius, S. |
| description | The plasma half-lives of five drugs, phenylbutazone, antipyrine, oxotremorine, nortriptyline and desmethylimipramine were compared
in vivo and in the isolated perfused rat liver. All drugs showed first order elimination in the perfusion experiments over wide concentration ranges. The half-lives
in vivo and in the isolated perfused liver agreed well for drugs with a small volume of distribution (antipyrine, oxotremorine and phenylbutazone) but were markedly different for those with a large volume of distribution (nortriptyline and desmethylimipramine). The half lives of the latter two drugs were 30 times longer
in vivo than in the perfused liver.
After phenobarbital treatment of rats
in vivo the elimination rate of phenylbutazone increased both
in vivo and in the isolated perfused liver in a parallel manner. The disappearance of this drug was also shown to be associated with the appearance of its metabolite oxyphenbutazone. |
| doi_str_mv | 10.1016/0014-2999(70)90326-2 |
| format | Article |
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in vivo and in the isolated perfused rat liver. All drugs showed first order elimination in the perfusion experiments over wide concentration ranges. The half-lives
in vivo and in the isolated perfused liver agreed well for drugs with a small volume of distribution (antipyrine, oxotremorine and phenylbutazone) but were markedly different for those with a large volume of distribution (nortriptyline and desmethylimipramine). The half lives of the latter two drugs were 30 times longer
in vivo than in the perfused liver.
After phenobarbital treatment of rats
in vivo the elimination rate of phenylbutazone increased both
in vivo and in the isolated perfused liver in a parallel manner. The disappearance of this drug was also shown to be associated with the appearance of its metabolite oxyphenbutazone.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(70)90326-2</identifier><identifier>PMID: 5434299</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antipyrine ; Antipyrine - metabolism ; Desipramine - blood ; Desipramine - metabolism ; Desmethylimipramine ; Drug metabolism ; Enzyme Induction ; In Vitro Techniques ; Liver - metabolism ; Male ; Nortriptyline ; Nortriptyline - blood ; Nortriptyline - metabolism ; Oxotremorine ; Perfused rat liver ; Perfusion ; Phenobarbital - pharmacology ; Phenylbutazone ; Phenylbutazone - blood ; Phenylbutazone - metabolism ; Rats ; Tremorine - blood ; Tremorine - metabolism ; Volume of distribution</subject><ispartof>European journal of pharmacology, 1970, Vol.9 (1), p.99-105</ispartof><rights>1970</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-e197e3ee4db4e3ba06e7da673dfd796514651cba789956521c7129bf215c9b5c3</citedby><cites>FETCH-LOGICAL-c272t-e197e3ee4db4e3ba06e7da673dfd796514651cba789956521c7129bf215c9b5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(70)90326-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5434299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Von Bahr, C.</creatorcontrib><creatorcontrib>Alexanderson, B.</creatorcontrib><creatorcontrib>Azarnoff, D.L.</creatorcontrib><creatorcontrib>Sjöqvist, F.</creatorcontrib><creatorcontrib>Orrenius, S.</creatorcontrib><title>A comparative study of drug metabolism in the isolated perfused liver and in vivo in rats</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The plasma half-lives of five drugs, phenylbutazone, antipyrine, oxotremorine, nortriptyline and desmethylimipramine were compared
in vivo and in the isolated perfused rat liver. All drugs showed first order elimination in the perfusion experiments over wide concentration ranges. The half-lives
in vivo and in the isolated perfused liver agreed well for drugs with a small volume of distribution (antipyrine, oxotremorine and phenylbutazone) but were markedly different for those with a large volume of distribution (nortriptyline and desmethylimipramine). The half lives of the latter two drugs were 30 times longer
in vivo than in the perfused liver.
After phenobarbital treatment of rats
in vivo the elimination rate of phenylbutazone increased both
in vivo and in the isolated perfused liver in a parallel manner. The disappearance of this drug was also shown to be associated with the appearance of its metabolite oxyphenbutazone.</description><subject>Animals</subject><subject>Antipyrine</subject><subject>Antipyrine - metabolism</subject><subject>Desipramine - blood</subject><subject>Desipramine - metabolism</subject><subject>Desmethylimipramine</subject><subject>Drug metabolism</subject><subject>Enzyme Induction</subject><subject>In Vitro Techniques</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Nortriptyline</subject><subject>Nortriptyline - blood</subject><subject>Nortriptyline - metabolism</subject><subject>Oxotremorine</subject><subject>Perfused rat liver</subject><subject>Perfusion</subject><subject>Phenobarbital - pharmacology</subject><subject>Phenylbutazone</subject><subject>Phenylbutazone - blood</subject><subject>Phenylbutazone - metabolism</subject><subject>Rats</subject><subject>Tremorine - blood</subject><subject>Tremorine - metabolism</subject><subject>Volume of distribution</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMo67r6DRRyEj1Uk7RpNhdhWfwHC1704CmkyVQj7WZN2sJ-e1N38ehhmCHz3gvzQ-ickhtKaHlLCC0yJqW8EuRakpyVGTtAUzoXMiOCskM0_ZMco5MYvwghXDI-QRNe5EV6n6L3BTa-3eigOzcAjl1vt9jX2Ib-A7fQ6co3LrbYrXH3CdhF3-gOLN5AqPuYhibZAtZrO0oGN_ixp7R4io5q3UQ42_cZenu4f10-ZauXx-flYpUZJliXAZUCcoDCVgXklSYlCKtLkdvaCllyWqQylRZzKXnJGTXpNFnVjHIjK27yGbrc5W6C_-4hdqp10UDT6DX4Pqp5wRkjRCRhsROa4GMMUKtNcK0OW0WJGomqEZcacSlB1C9RxZLtYp_fVy3YP9MeYdrf7faQjhwcBBWNg7UB6wKYTlnv_v_gB2irhS0</recordid><startdate>1970</startdate><enddate>1970</enddate><creator>Von Bahr, C.</creator><creator>Alexanderson, B.</creator><creator>Azarnoff, D.L.</creator><creator>Sjöqvist, F.</creator><creator>Orrenius, S.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1970</creationdate><title>A comparative study of drug metabolism in the isolated perfused liver and in vivo in rats</title><author>Von Bahr, C. ; Alexanderson, B. ; Azarnoff, D.L. ; Sjöqvist, F. ; Orrenius, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-e197e3ee4db4e3ba06e7da673dfd796514651cba789956521c7129bf215c9b5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Animals</topic><topic>Antipyrine</topic><topic>Antipyrine - metabolism</topic><topic>Desipramine - blood</topic><topic>Desipramine - metabolism</topic><topic>Desmethylimipramine</topic><topic>Drug metabolism</topic><topic>Enzyme Induction</topic><topic>In Vitro Techniques</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Nortriptyline</topic><topic>Nortriptyline - blood</topic><topic>Nortriptyline - metabolism</topic><topic>Oxotremorine</topic><topic>Perfused rat liver</topic><topic>Perfusion</topic><topic>Phenobarbital - pharmacology</topic><topic>Phenylbutazone</topic><topic>Phenylbutazone - blood</topic><topic>Phenylbutazone - metabolism</topic><topic>Rats</topic><topic>Tremorine - blood</topic><topic>Tremorine - metabolism</topic><topic>Volume of distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Von Bahr, C.</creatorcontrib><creatorcontrib>Alexanderson, B.</creatorcontrib><creatorcontrib>Azarnoff, D.L.</creatorcontrib><creatorcontrib>Sjöqvist, F.</creatorcontrib><creatorcontrib>Orrenius, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Von Bahr, C.</au><au>Alexanderson, B.</au><au>Azarnoff, D.L.</au><au>Sjöqvist, F.</au><au>Orrenius, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparative study of drug metabolism in the isolated perfused liver and in vivo in rats</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1970</date><risdate>1970</risdate><volume>9</volume><issue>1</issue><spage>99</spage><epage>105</epage><pages>99-105</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>The plasma half-lives of five drugs, phenylbutazone, antipyrine, oxotremorine, nortriptyline and desmethylimipramine were compared
in vivo and in the isolated perfused rat liver. All drugs showed first order elimination in the perfusion experiments over wide concentration ranges. The half-lives
in vivo and in the isolated perfused liver agreed well for drugs with a small volume of distribution (antipyrine, oxotremorine and phenylbutazone) but were markedly different for those with a large volume of distribution (nortriptyline and desmethylimipramine). The half lives of the latter two drugs were 30 times longer
in vivo than in the perfused liver.
After phenobarbital treatment of rats
in vivo the elimination rate of phenylbutazone increased both
in vivo and in the isolated perfused liver in a parallel manner. The disappearance of this drug was also shown to be associated with the appearance of its metabolite oxyphenbutazone.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>5434299</pmid><doi>10.1016/0014-2999(70)90326-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1970, Vol.9 (1), p.99-105 |
| issn | 0014-2999 1879-0712 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84522007 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Antipyrine Antipyrine - metabolism Desipramine - blood Desipramine - metabolism Desmethylimipramine Drug metabolism Enzyme Induction In Vitro Techniques Liver - metabolism Male Nortriptyline Nortriptyline - blood Nortriptyline - metabolism Oxotremorine Perfused rat liver Perfusion Phenobarbital - pharmacology Phenylbutazone Phenylbutazone - blood Phenylbutazone - metabolism Rats Tremorine - blood Tremorine - metabolism Volume of distribution |
| title | A comparative study of drug metabolism in the isolated perfused liver and in vivo in rats |
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