Metabolism of doubly labelled ethynylestradiol-3-cyclopentyl ether in women
The metabolic fate of orally administered 17α-ethynylestradiol-3-cyclopentyl ether (EECPE) labelled with 3H in the steroid nucleus and with 14C in the cyclo-pentyl group has been studied in women in two independent laboratories. Radioactivity was excreted over a period of up to 127 days, and unchang...
Gespeichert in:
| Veröffentlicht in: | Steroids 1967-03, Vol.9 (3), p.275-287 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 287 |
|---|---|
| container_issue | 3 |
| container_start_page | 275 |
| container_title | Steroids |
| container_volume | 9 |
| creator | Williams, K.I.H. Layne, D.S. Hobkirk, R. Nilsen, M. Blahey, P.R. |
| description | The metabolic fate of orally administered 17α-ethynylestradiol-3-cyclopentyl ether (EECPE) labelled with
3H in the steroid nucleus and with
14C in the cyclo-pentyl group has been studied in women in two independent laboratories. Radioactivity was excreted over a period of up to 127 days, and unchanged EECPE was recovered from fat at 2 and 3 days after ingestion. Substantial quantities of ethynylestradiol were identified in the processed urine by recrystallization with carrier. Three other urinary metabolites were detected; the least polar contained
3H and
14C but was not EECPE. This metabolite is probably present in the urine over the entire excretion period. The most polar metabolite contained only
3H and was quantitatively prominent in urines from the first few days collections but disappeared from the excretion pattern with time. A metabolite of intermediate polarity increased in relative amount during the collection period. |
| doi_str_mv | 10.1016/0039-128X(67)90112-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_84513880</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0039128X67901122</els_id><sourcerecordid>84513880</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-d0f809f49105163098075bd83cb6b9d36e34f0796575dda9aeb701f457e1e3253</originalsourceid><addsrcrecordid>eNp9kEtr3DAQx0Vo2G62-QYp-FSag5ORZb0uhRDyIhtyaSE3YUtjqiJbW8mb4m9fb3fZY09z-D9m5kfIBYUrClRcAzBd0kq9fRXyUgOlVVmdkCVVUpVcCfmBLI-Wj-Qs518AIJiuFmQhoAbBYUmeX3Bs2hh87ovYFS5u2zAVoWkxBHQFjj-nYQqYx9Q4H0PJSjvZEDc4jFPYyZgKPxR_Yo_DJ3LaNSHj-WGuyI_7u--3j-X69eHp9mZdWsblWDroFOiu1hQ4FQy0Aslbp5htRasdE8jqDqQWXHLnGt1gK4F2NZdIkVWcrciXfe8mxd_b-TbT-2zng5sB4zYbVXPKlILZWO-NNsWcE3Zmk3zfpMlQMDuGZgfI7AAZIc0_hqaaY58P_du2R3cMHaDN-re9jvOT7x6TydbjYNH5hHY0Lvr_L_gLuxmAhw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>84513880</pqid></control><display><type>article</type><title>Metabolism of doubly labelled ethynylestradiol-3-cyclopentyl ether in women</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Williams, K.I.H. ; Layne, D.S. ; Hobkirk, R. ; Nilsen, M. ; Blahey, P.R.</creator><creatorcontrib>Williams, K.I.H. ; Layne, D.S. ; Hobkirk, R. ; Nilsen, M. ; Blahey, P.R.</creatorcontrib><description>The metabolic fate of orally administered 17α-ethynylestradiol-3-cyclopentyl ether (EECPE) labelled with
3H in the steroid nucleus and with
14C in the cyclo-pentyl group has been studied in women in two independent laboratories. Radioactivity was excreted over a period of up to 127 days, and unchanged EECPE was recovered from fat at 2 and 3 days after ingestion. Substantial quantities of ethynylestradiol were identified in the processed urine by recrystallization with carrier. Three other urinary metabolites were detected; the least polar contained
3H and
14C but was not EECPE. This metabolite is probably present in the urine over the entire excretion period. The most polar metabolite contained only
3H and was quantitatively prominent in urines from the first few days collections but disappeared from the excretion pattern with time. A metabolite of intermediate polarity increased in relative amount during the collection period.</description><identifier>ISSN: 0039-128X</identifier><identifier>EISSN: 1878-5867</identifier><identifier>DOI: 10.1016/0039-128X(67)90112-2</identifier><identifier>PMID: 6040650</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Carbon Isotopes ; Chromatography, Thin Layer ; Crystallization ; Ethers - metabolism ; Ethinyl Estradiol - metabolism ; Ethinyl Estradiol - pharmacology ; Ethinyl Estradiol - urine ; Female ; Glucuronidase - analysis ; Humans ; Middle Aged ; Ovulation - drug effects ; Tritium</subject><ispartof>Steroids, 1967-03, Vol.9 (3), p.275-287</ispartof><rights>1967</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-d0f809f49105163098075bd83cb6b9d36e34f0796575dda9aeb701f457e1e3253</citedby><cites>FETCH-LOGICAL-c357t-d0f809f49105163098075bd83cb6b9d36e34f0796575dda9aeb701f457e1e3253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0039-128X(67)90112-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6040650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, K.I.H.</creatorcontrib><creatorcontrib>Layne, D.S.</creatorcontrib><creatorcontrib>Hobkirk, R.</creatorcontrib><creatorcontrib>Nilsen, M.</creatorcontrib><creatorcontrib>Blahey, P.R.</creatorcontrib><title>Metabolism of doubly labelled ethynylestradiol-3-cyclopentyl ether in women</title><title>Steroids</title><addtitle>Steroids</addtitle><description>The metabolic fate of orally administered 17α-ethynylestradiol-3-cyclopentyl ether (EECPE) labelled with
3H in the steroid nucleus and with
14C in the cyclo-pentyl group has been studied in women in two independent laboratories. Radioactivity was excreted over a period of up to 127 days, and unchanged EECPE was recovered from fat at 2 and 3 days after ingestion. Substantial quantities of ethynylestradiol were identified in the processed urine by recrystallization with carrier. Three other urinary metabolites were detected; the least polar contained
3H and
14C but was not EECPE. This metabolite is probably present in the urine over the entire excretion period. The most polar metabolite contained only
3H and was quantitatively prominent in urines from the first few days collections but disappeared from the excretion pattern with time. A metabolite of intermediate polarity increased in relative amount during the collection period.</description><subject>Adult</subject><subject>Carbon Isotopes</subject><subject>Chromatography, Thin Layer</subject><subject>Crystallization</subject><subject>Ethers - metabolism</subject><subject>Ethinyl Estradiol - metabolism</subject><subject>Ethinyl Estradiol - pharmacology</subject><subject>Ethinyl Estradiol - urine</subject><subject>Female</subject><subject>Glucuronidase - analysis</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Ovulation - drug effects</subject><subject>Tritium</subject><issn>0039-128X</issn><issn>1878-5867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtr3DAQx0Vo2G62-QYp-FSag5ORZb0uhRDyIhtyaSE3YUtjqiJbW8mb4m9fb3fZY09z-D9m5kfIBYUrClRcAzBd0kq9fRXyUgOlVVmdkCVVUpVcCfmBLI-Wj-Qs518AIJiuFmQhoAbBYUmeX3Bs2hh87ovYFS5u2zAVoWkxBHQFjj-nYQqYx9Q4H0PJSjvZEDc4jFPYyZgKPxR_Yo_DJ3LaNSHj-WGuyI_7u--3j-X69eHp9mZdWsblWDroFOiu1hQ4FQy0Aslbp5htRasdE8jqDqQWXHLnGt1gK4F2NZdIkVWcrciXfe8mxd_b-TbT-2zng5sB4zYbVXPKlILZWO-NNsWcE3Zmk3zfpMlQMDuGZgfI7AAZIc0_hqaaY58P_du2R3cMHaDN-re9jvOT7x6TydbjYNH5hHY0Lvr_L_gLuxmAhw</recordid><startdate>196703</startdate><enddate>196703</enddate><creator>Williams, K.I.H.</creator><creator>Layne, D.S.</creator><creator>Hobkirk, R.</creator><creator>Nilsen, M.</creator><creator>Blahey, P.R.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196703</creationdate><title>Metabolism of doubly labelled ethynylestradiol-3-cyclopentyl ether in women</title><author>Williams, K.I.H. ; Layne, D.S. ; Hobkirk, R. ; Nilsen, M. ; Blahey, P.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-d0f809f49105163098075bd83cb6b9d36e34f0796575dda9aeb701f457e1e3253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Adult</topic><topic>Carbon Isotopes</topic><topic>Chromatography, Thin Layer</topic><topic>Crystallization</topic><topic>Ethers - metabolism</topic><topic>Ethinyl Estradiol - metabolism</topic><topic>Ethinyl Estradiol - pharmacology</topic><topic>Ethinyl Estradiol - urine</topic><topic>Female</topic><topic>Glucuronidase - analysis</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Ovulation - drug effects</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, K.I.H.</creatorcontrib><creatorcontrib>Layne, D.S.</creatorcontrib><creatorcontrib>Hobkirk, R.</creatorcontrib><creatorcontrib>Nilsen, M.</creatorcontrib><creatorcontrib>Blahey, P.R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Steroids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, K.I.H.</au><au>Layne, D.S.</au><au>Hobkirk, R.</au><au>Nilsen, M.</au><au>Blahey, P.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolism of doubly labelled ethynylestradiol-3-cyclopentyl ether in women</atitle><jtitle>Steroids</jtitle><addtitle>Steroids</addtitle><date>1967-03</date><risdate>1967</risdate><volume>9</volume><issue>3</issue><spage>275</spage><epage>287</epage><pages>275-287</pages><issn>0039-128X</issn><eissn>1878-5867</eissn><abstract>The metabolic fate of orally administered 17α-ethynylestradiol-3-cyclopentyl ether (EECPE) labelled with
3H in the steroid nucleus and with
14C in the cyclo-pentyl group has been studied in women in two independent laboratories. Radioactivity was excreted over a period of up to 127 days, and unchanged EECPE was recovered from fat at 2 and 3 days after ingestion. Substantial quantities of ethynylestradiol were identified in the processed urine by recrystallization with carrier. Three other urinary metabolites were detected; the least polar contained
3H and
14C but was not EECPE. This metabolite is probably present in the urine over the entire excretion period. The most polar metabolite contained only
3H and was quantitatively prominent in urines from the first few days collections but disappeared from the excretion pattern with time. A metabolite of intermediate polarity increased in relative amount during the collection period.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6040650</pmid><doi>10.1016/0039-128X(67)90112-2</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-128X |
| ispartof | Steroids, 1967-03, Vol.9 (3), p.275-287 |
| issn | 0039-128X 1878-5867 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84513880 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Carbon Isotopes Chromatography, Thin Layer Crystallization Ethers - metabolism Ethinyl Estradiol - metabolism Ethinyl Estradiol - pharmacology Ethinyl Estradiol - urine Female Glucuronidase - analysis Humans Middle Aged Ovulation - drug effects Tritium |
| title | Metabolism of doubly labelled ethynylestradiol-3-cyclopentyl ether in women |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T10%3A58%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metabolism%20of%20doubly%20labelled%20ethynylestradiol-3-cyclopentyl%20ether%20in%20women&rft.jtitle=Steroids&rft.au=Williams,%20K.I.H.&rft.date=1967-03&rft.volume=9&rft.issue=3&rft.spage=275&rft.epage=287&rft.pages=275-287&rft.issn=0039-128X&rft.eissn=1878-5867&rft_id=info:doi/10.1016/0039-128X(67)90112-2&rft_dat=%3Cproquest_cross%3E84513880%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=84513880&rft_id=info:pmid/6040650&rft_els_id=0039128X67901122&rfr_iscdi=true |