Changes in erythrocyte I agglutinogen and anti-I-agglutinins during Mycoplasma pneumoniae infection in man
Changes in the erythrocyte I agglutinogen and in serum anti-I agglutinins were studied following experimental infection of 27 adult volunteers with Mycoplasma pneumoniae. An increase in thermal amplitude of anti-I agglutinins developed in 12, among whom seven had simultaneous rises in titer of cold...
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| Veröffentlicht in: | The Journal of immunology (1950) 1967-08, Vol.99 (2), p.333-339 |
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| container_end_page | 339 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 99 |
| creator | Smith, C B McGinniss, M H Schmidt, P J |
| description | Changes in the erythrocyte I agglutinogen and in serum anti-I agglutinins were studied following experimental infection of 27 adult volunteers with Mycoplasma pneumoniae. An increase in thermal amplitude of anti-I agglutinins developed in 12, among whom seven had simultaneous rises in titer of cold agglutinins. The activity of the erythrocyte I agglutinogen was transiently reduced following M. pneumoniae infection in five of the volunteers. These changes were not associated with clinical or laboratory evidence of hemolytic anemia. The possibility that M. pneumoniae organisms directly altered the erythrocyte I antigen leading to the production of anti-I antibodies is discussed. |
| doi_str_mv | 10.4049/jimmunol.99.2.333 |
| format | Article |
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An increase in thermal amplitude of anti-I agglutinins developed in 12, among whom seven had simultaneous rises in titer of cold agglutinins. The activity of the erythrocyte I agglutinogen was transiently reduced following M. pneumoniae infection in five of the volunteers. These changes were not associated with clinical or laboratory evidence of hemolytic anemia. 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An increase in thermal amplitude of anti-I agglutinins developed in 12, among whom seven had simultaneous rises in titer of cold agglutinins. The activity of the erythrocyte I agglutinogen was transiently reduced following M. pneumoniae infection in five of the volunteers. These changes were not associated with clinical or laboratory evidence of hemolytic anemia. The possibility that M. pneumoniae organisms directly altered the erythrocyte I antigen leading to the production of anti-I antibodies is discussed.</description><subject>Antibodies</subject><subject>Antigens</subject><subject>Blood Group Antigens</subject><subject>Erythrocytes</subject><subject>Hemagglutination</subject><subject>Humans</subject><subject>Male</subject><subject>Mycoplasma - immunology</subject><subject>Pleuropneumonia - immunology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1PwzAURS0EKqXwAxiQPLElPMeOE4-o4qNSEQvMlus4qavEDnYy5N-TqoXh6UpP957hIHRPIGXAxNPBdt3ofJsKkWYppfQCLUmeQ8I58Eu0BMiyhBS8uEY3MR4AgEPGFmjBgZIM8iU6rPfKNSZi67AJ07APXk-DwRusmqYdB-t8YxxWrppvsMkm-ftbF3E1Busa_DFp37cqdgr3zoydd1aZmVgbPVjvjuxOuVt0Vas2mrtzrtD368vX-j3Zfr5t1s_bRFMqhoSoWqvc7EoOO15TygXhBWgguqxZlUMmtKC6ZJqWUFdKcVC8AmAmp0QUnNMVejxx--B_RhMH2dmoTdsqZ_wYZcmYKAqRz0VyKurgYwymln2wnQqTJCCPfuWfXymEzOTsd948nOHjrjPV_-IslP4CJ456Lw</recordid><startdate>196708</startdate><enddate>196708</enddate><creator>Smith, C B</creator><creator>McGinniss, M H</creator><creator>Schmidt, P J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196708</creationdate><title>Changes in erythrocyte I agglutinogen and anti-I-agglutinins during Mycoplasma pneumoniae infection in man</title><author>Smith, C B ; McGinniss, M H ; Schmidt, P J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-1afca5eb860b6f33691670c01c8f4d5029c93c84c380fdaa60a6d004e53197663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Antibodies</topic><topic>Antigens</topic><topic>Blood Group Antigens</topic><topic>Erythrocytes</topic><topic>Hemagglutination</topic><topic>Humans</topic><topic>Male</topic><topic>Mycoplasma - immunology</topic><topic>Pleuropneumonia - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, C B</creatorcontrib><creatorcontrib>McGinniss, M H</creatorcontrib><creatorcontrib>Schmidt, P J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, C B</au><au>McGinniss, M H</au><au>Schmidt, P J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in erythrocyte I agglutinogen and anti-I-agglutinins during Mycoplasma pneumoniae infection in man</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1967-08</date><risdate>1967</risdate><volume>99</volume><issue>2</issue><spage>333</spage><epage>339</epage><pages>333-339</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>Changes in the erythrocyte I agglutinogen and in serum anti-I agglutinins were studied following experimental infection of 27 adult volunteers with Mycoplasma pneumoniae. An increase in thermal amplitude of anti-I agglutinins developed in 12, among whom seven had simultaneous rises in titer of cold agglutinins. The activity of the erythrocyte I agglutinogen was transiently reduced following M. pneumoniae infection in five of the volunteers. These changes were not associated with clinical or laboratory evidence of hemolytic anemia. The possibility that M. pneumoniae organisms directly altered the erythrocyte I antigen leading to the production of anti-I antibodies is discussed.</abstract><cop>United States</cop><pmid>6031205</pmid><doi>10.4049/jimmunol.99.2.333</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of immunology (1950), 1967-08, Vol.99 (2), p.333-339 |
| issn | 0022-1767 1550-6606 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Antibodies Antigens Blood Group Antigens Erythrocytes Hemagglutination Humans Male Mycoplasma - immunology Pleuropneumonia - immunology |
| title | Changes in erythrocyte I agglutinogen and anti-I-agglutinins during Mycoplasma pneumoniae infection in man |
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