Exercise-induced bronchospasm: Effect of adrenergic or cholinergic blockade
To assess the role of the autonomic nervous system in the bronchospasm which occurs in asthmatic children following exercise, β-adrenergic, α-adrenergic, or cholinergic blockade was induced by the intravenous injection of propranolol, phentolamine, or atropine, respectively, with saline as a control...
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| Veröffentlicht in: | The Journal of allergy 1967-08, Vol.40 (2), p.93-99 |
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| container_title | The Journal of allergy |
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| creator | Sly, R. Michael Heimlich, Ernest M. Busser, Ray J. Strick, Lawrence |
| description | To assess the role of the autonomic nervous system in the bronchospasm which occurs in asthmatic children following exercise, β-adrenergic, α-adrenergic, or cholinergic blockade was induced by the intravenous injection of propranolol, phentolamine, or atropine, respectively, with saline as a control. Treatments were given by random assignment once to each of 10 asthmatic children on each of four successive afternoons, with each child acting as his own control. Measurement of peak expiratory flow rates (PEFR) before injections, 15 minutes later before standard treadmill exercise, and 10 minutes after completion of 8 minutes of exercise disclosed a significant decrease in PEFR following injection with propranolol only. Pulse rate alterations were consistent with the various kinds of blockade sought. None of the treatments affected the decrease in PEFR induced by exercise. It seems unlikely, therefore, that exercise-induced bronchospasm is mediated in major fashion by the autonomic nervous system. |
| doi_str_mv | 10.1016/0021-8707(67)90102-5 |
| format | Article |
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Pulse rate alterations were consistent with the various kinds of blockade sought. None of the treatments affected the decrease in PEFR induced by exercise. It seems unlikely, therefore, that exercise-induced bronchospasm is mediated in major fashion by the autonomic nervous system.</description><identifier>ISSN: 0021-8707</identifier><identifier>DOI: 10.1016/0021-8707(67)90102-5</identifier><identifier>PMID: 5230414</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Asthma - physiopathology ; Atropine - pharmacology ; Bronchial Spasm - etiology ; Cardiovascular System - drug effects ; Child ; Humans ; Phentolamine - pharmacology ; Physical Exertion ; Propranolol - pharmacology ; Pulse ; Respiration - drug effects ; Respiratory Function Tests ; Sodium Chloride - pharmacology</subject><ispartof>The Journal of allergy, 1967-08, Vol.40 (2), p.93-99</ispartof><rights>1967 The C. V. 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Michael</creatorcontrib><creatorcontrib>Heimlich, Ernest M.</creatorcontrib><creatorcontrib>Busser, Ray J.</creatorcontrib><creatorcontrib>Strick, Lawrence</creatorcontrib><title>Exercise-induced bronchospasm: Effect of adrenergic or cholinergic blockade</title><title>The Journal of allergy</title><addtitle>J Allergy</addtitle><description>To assess the role of the autonomic nervous system in the bronchospasm which occurs in asthmatic children following exercise, β-adrenergic, α-adrenergic, or cholinergic blockade was induced by the intravenous injection of propranolol, phentolamine, or atropine, respectively, with saline as a control. Treatments were given by random assignment once to each of 10 asthmatic children on each of four successive afternoons, with each child acting as his own control. Measurement of peak expiratory flow rates (PEFR) before injections, 15 minutes later before standard treadmill exercise, and 10 minutes after completion of 8 minutes of exercise disclosed a significant decrease in PEFR following injection with propranolol only. Pulse rate alterations were consistent with the various kinds of blockade sought. None of the treatments affected the decrease in PEFR induced by exercise. It seems unlikely, therefore, that exercise-induced bronchospasm is mediated in major fashion by the autonomic nervous system.</description><subject>Asthma - physiopathology</subject><subject>Atropine - pharmacology</subject><subject>Bronchial Spasm - etiology</subject><subject>Cardiovascular System - drug effects</subject><subject>Child</subject><subject>Humans</subject><subject>Phentolamine - pharmacology</subject><subject>Physical Exertion</subject><subject>Propranolol - pharmacology</subject><subject>Pulse</subject><subject>Respiration - drug effects</subject><subject>Respiratory Function Tests</subject><subject>Sodium Chloride - pharmacology</subject><issn>0021-8707</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOAzEMRbMAlVL4A5BmhWAx4EySScoCCVXlISqxgXWUhwcC00lJWgR_z5RWLFlZ9r3Xlg8hRxTOKdD6AqCipZIgT2t5NgYKVSl2yPBvvEf2c34DYHIMYkAGomLAKR-Sh-kXJhcylqHzK4e-sCl27jXmhcnzy2LaNOiWRWwK4xN2mF6CK2Iqekcbtq1to3s3Hg_IbmPajIfbOiLPN9OnyV05e7y9n1zPSseEXJauptKBrUWlhKwVA-N8LRWrOBXeCmmUAcPGAMZSqxg3vuJAnePMWopNxUbkZLN3keLHCvNSz0N22Lamw7jKWnGuuGCqN_KN0aWYc8JGL1KYm_StKeg1N70GpNeAdC31Lzct-tjxdv_KztH_hbbQev1qo2P_5GfApLML2PXwQuphaR_D_wd-AF_ofcU</recordid><startdate>196708</startdate><enddate>196708</enddate><creator>Sly, R. 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Michael ; Heimlich, Ernest M. ; Busser, Ray J. ; Strick, Lawrence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-c617c0b6528576830acd67832415db57a8a0a3900ab1b834ad2401cc43bb1ef23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Asthma - physiopathology</topic><topic>Atropine - pharmacology</topic><topic>Bronchial Spasm - etiology</topic><topic>Cardiovascular System - drug effects</topic><topic>Child</topic><topic>Humans</topic><topic>Phentolamine - pharmacology</topic><topic>Physical Exertion</topic><topic>Propranolol - pharmacology</topic><topic>Pulse</topic><topic>Respiration - drug effects</topic><topic>Respiratory Function Tests</topic><topic>Sodium Chloride - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>Sly, R. Michael</creatorcontrib><creatorcontrib>Heimlich, Ernest M.</creatorcontrib><creatorcontrib>Busser, Ray J.</creatorcontrib><creatorcontrib>Strick, Lawrence</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sly, R. Michael</au><au>Heimlich, Ernest M.</au><au>Busser, Ray J.</au><au>Strick, Lawrence</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise-induced bronchospasm: Effect of adrenergic or cholinergic blockade</atitle><jtitle>The Journal of allergy</jtitle><addtitle>J Allergy</addtitle><date>1967-08</date><risdate>1967</risdate><volume>40</volume><issue>2</issue><spage>93</spage><epage>99</epage><pages>93-99</pages><issn>0021-8707</issn><abstract>To assess the role of the autonomic nervous system in the bronchospasm which occurs in asthmatic children following exercise, β-adrenergic, α-adrenergic, or cholinergic blockade was induced by the intravenous injection of propranolol, phentolamine, or atropine, respectively, with saline as a control. Treatments were given by random assignment once to each of 10 asthmatic children on each of four successive afternoons, with each child acting as his own control. Measurement of peak expiratory flow rates (PEFR) before injections, 15 minutes later before standard treadmill exercise, and 10 minutes after completion of 8 minutes of exercise disclosed a significant decrease in PEFR following injection with propranolol only. Pulse rate alterations were consistent with the various kinds of blockade sought. None of the treatments affected the decrease in PEFR induced by exercise. It seems unlikely, therefore, that exercise-induced bronchospasm is mediated in major fashion by the autonomic nervous system.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>5230414</pmid><doi>10.1016/0021-8707(67)90102-5</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8707 |
| ispartof | The Journal of allergy, 1967-08, Vol.40 (2), p.93-99 |
| issn | 0021-8707 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Asthma - physiopathology Atropine - pharmacology Bronchial Spasm - etiology Cardiovascular System - drug effects Child Humans Phentolamine - pharmacology Physical Exertion Propranolol - pharmacology Pulse Respiration - drug effects Respiratory Function Tests Sodium Chloride - pharmacology |
| title | Exercise-induced bronchospasm: Effect of adrenergic or cholinergic blockade |
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