Chemical Composition of Human Skin Surface Lipids from Birth to Puberty
Skin surface lipids from the foreheads of 51 subjects between the ages of five days and fifteen years were analyzed by quantitative thin-layer chromatography. The cholesterol concentrations were low at birth, at maximum levels at six years of age, and low again, almost to adult levels, at nine years...
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| Veröffentlicht in: | Journal of investigative dermatology 1970-02, Vol.54 (2), p.139-144 |
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| container_end_page | 144 |
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| container_issue | 2 |
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| container_title | Journal of investigative dermatology |
| container_volume | 54 |
| creator | Ramasastry, Petra Downing, Donald T. Pochi, Peter E. Strauss, John S. |
| description | Skin surface lipids from the foreheads of 51 subjects between the ages of five days and fifteen years were analyzed by quantitative thin-layer chromatography. The cholesterol concentrations were low at birth, at maximum levels at six years of age, and low again, almost to adult levels, at nine years. Conversely, average concentrations of wax esters were high at birth, low between the ages of three and six years, and rising towards adult levels by nine years. There was no significant change in the combined concentrations of triglycerides plus free fatty acids during development. Concentrations of squalene were highly variable, in contrast to the constant proportions previously reported for adults. |
| doi_str_mv | 10.1111/1523-1747.ep12257164 |
| format | Article |
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The cholesterol concentrations were low at birth, at maximum levels at six years of age, and low again, almost to adult levels, at nine years. Conversely, average concentrations of wax esters were high at birth, low between the ages of three and six years, and rising towards adult levels by nine years. There was no significant change in the combined concentrations of triglycerides plus free fatty acids during development. Concentrations of squalene were highly variable, in contrast to the constant proportions previously reported for adults.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1111/1523-1747.ep12257164</identifier><identifier>PMID: 5414607</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Aging ; Child ; Child, Preschool ; Cholesterol - analysis ; Chromatography, Thin Layer ; Esters - analysis ; Face ; Fatty Acids - analysis ; Humans ; Infant ; Infant, Newborn ; Lipids - analysis ; Skin ; Squalene - analysis ; Triglycerides - analysis ; Waxes - analysis</subject><ispartof>Journal of investigative dermatology, 1970-02, Vol.54 (2), p.139-144</ispartof><rights>1970 The Williams & Wilkins Co.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-e7ba0938cab2d43f07875e302abafb78f85fc450176a105e044dc6453356ecb03</citedby><cites>FETCH-LOGICAL-c491t-e7ba0938cab2d43f07875e302abafb78f85fc450176a105e044dc6453356ecb03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5414607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramasastry, Petra</creatorcontrib><creatorcontrib>Downing, Donald T.</creatorcontrib><creatorcontrib>Pochi, Peter E.</creatorcontrib><creatorcontrib>Strauss, John S.</creatorcontrib><title>Chemical Composition of Human Skin Surface Lipids from Birth to Puberty</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>Skin surface lipids from the foreheads of 51 subjects between the ages of five days and fifteen years were analyzed by quantitative thin-layer chromatography. The cholesterol concentrations were low at birth, at maximum levels at six years of age, and low again, almost to adult levels, at nine years. Conversely, average concentrations of wax esters were high at birth, low between the ages of three and six years, and rising towards adult levels by nine years. There was no significant change in the combined concentrations of triglycerides plus free fatty acids during development. Concentrations of squalene were highly variable, in contrast to the constant proportions previously reported for adults.</description><subject>Adolescent</subject><subject>Aging</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cholesterol - analysis</subject><subject>Chromatography, Thin Layer</subject><subject>Esters - analysis</subject><subject>Face</subject><subject>Fatty Acids - analysis</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Lipids - analysis</subject><subject>Skin</subject><subject>Squalene - analysis</subject><subject>Triglycerides - analysis</subject><subject>Waxes - analysis</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo6_rxDxRy8ladpElTL4IufsGCggreQppOMLptatIK--_tsot7cw4zMO87HzyEnDA4Z2NcMMnzjCmhzrFjnEvFCrFDpn_tXTIF4DzjwN_3yUFKnwCjRZYTMpGCiQLUlNzPPrDx1izoLDRdSL73oaXB0YehMS19-fJjGqIzFuncd75O1MXQ0Bsf-w_aB_o8VBj75RHZc2aR8HhTD8nb3e3r7CGbP90_zq7nmRWXrM9QVQYu89Kaitcid6BKJTEHbirjKlW6UjorJDBVGAYSQYjajj_nuSzQVpAfkrP13i6G7wFTrxufLC4WpsUwJF0KoUqAfDSKtdHGkFJEp7voGxOXmoFe8dMrUHoFSm_5jWOnm_1D1WD9N7QBttVb0w8Rt3rBSs5XZ6_WOo4QfjxGnazH1mLtI9pe18H__8AvMfeIQQ</recordid><startdate>197002</startdate><enddate>197002</enddate><creator>Ramasastry, Petra</creator><creator>Downing, Donald T.</creator><creator>Pochi, Peter E.</creator><creator>Strauss, John S.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197002</creationdate><title>Chemical Composition of Human Skin Surface Lipids from Birth to Puberty</title><author>Ramasastry, Petra ; Downing, Donald T. ; Pochi, Peter E. ; Strauss, John S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-e7ba0938cab2d43f07875e302abafb78f85fc450176a105e044dc6453356ecb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Adolescent</topic><topic>Aging</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cholesterol - analysis</topic><topic>Chromatography, Thin Layer</topic><topic>Esters - analysis</topic><topic>Face</topic><topic>Fatty Acids - analysis</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Lipids - analysis</topic><topic>Skin</topic><topic>Squalene - analysis</topic><topic>Triglycerides - analysis</topic><topic>Waxes - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramasastry, Petra</creatorcontrib><creatorcontrib>Downing, Donald T.</creatorcontrib><creatorcontrib>Pochi, Peter E.</creatorcontrib><creatorcontrib>Strauss, John S.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramasastry, Petra</au><au>Downing, Donald T.</au><au>Pochi, Peter E.</au><au>Strauss, John S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical Composition of Human Skin Surface Lipids from Birth to Puberty</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>1970-02</date><risdate>1970</risdate><volume>54</volume><issue>2</issue><spage>139</spage><epage>144</epage><pages>139-144</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><abstract>Skin surface lipids from the foreheads of 51 subjects between the ages of five days and fifteen years were analyzed by quantitative thin-layer chromatography. The cholesterol concentrations were low at birth, at maximum levels at six years of age, and low again, almost to adult levels, at nine years. Conversely, average concentrations of wax esters were high at birth, low between the ages of three and six years, and rising towards adult levels by nine years. There was no significant change in the combined concentrations of triglycerides plus free fatty acids during development. Concentrations of squalene were highly variable, in contrast to the constant proportions previously reported for adults.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>5414607</pmid><doi>10.1111/1523-1747.ep12257164</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-202X |
| ispartof | Journal of investigative dermatology, 1970-02, Vol.54 (2), p.139-144 |
| issn | 0022-202X 1523-1747 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Aging Child Child, Preschool Cholesterol - analysis Chromatography, Thin Layer Esters - analysis Face Fatty Acids - analysis Humans Infant Infant, Newborn Lipids - analysis Skin Squalene - analysis Triglycerides - analysis Waxes - analysis |
| title | Chemical Composition of Human Skin Surface Lipids from Birth to Puberty |
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