Serum Kynurenine in Bronchial Asthma and Chronic Bronchitis
Estimations of serum kynurenine were carried out in 20 normal Individuals, 20 patients with clinical evidence of chronic airway obstruction, and in 46 patients with airway obstruction in whom its presence and degree were also assessed by spirometry. The selection of patients was based on avoiding an...
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| Veröffentlicht in: | Chest 1970-02, Vol.57 (2), p.148-150 |
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| creator | Warraki, S.E. El-Gammal, M.Y. El-Asmar, M.F. Wahba, N. |
| description | Estimations of serum kynurenine were carried out in 20 normal Individuals, 20 patients with clinical evidence of chronic airway obstruction, and in 46 patients with airway obstruction in whom its presence and degree were also assessed by spirometry. The selection of patients was based on avoiding any possible cause of elevated serum kynurenine, at the same time ensuring a satisfactory state of nutrition, as well as normal liver function. The serum kynurenine mean value of the normal individuals was ± SD = 10 ± 2.29 mg percent. In the 20 patients with clinical evidence of chronic airway obstruction (no spirometry), all except one had higher serum kynurenine than the normal subjects. Of the 46 patients with clinical and spirometric evidence of chronic airway obstruction, 32 (69.6 percent) had high serum kynurenine values which were correlated with their indirect maximum breathing capacities. |
| doi_str_mv | 10.1378/chest.57.2.148 |
| format | Article |
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The selection of patients was based on avoiding any possible cause of elevated serum kynurenine, at the same time ensuring a satisfactory state of nutrition, as well as normal liver function. The serum kynurenine mean value of the normal individuals was ± SD = 10 ± 2.29 mg percent. In the 20 patients with clinical evidence of chronic airway obstruction (no spirometry), all except one had higher serum kynurenine than the normal subjects. Of the 46 patients with clinical and spirometric evidence of chronic airway obstruction, 32 (69.6 percent) had high serum kynurenine values which were correlated with their indirect maximum breathing capacities.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.57.2.148</identifier><identifier>PMID: 5411715</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Asthma - blood ; Bronchitis - blood ; Cortisone - pharmacology ; Female ; Humans ; Kynurenine - blood ; Male ; Methods ; Middle Aged ; Nicotinic Acids - biosynthesis ; Protein Biosynthesis ; Serotonin - biosynthesis ; Spirometry ; Tryptophan - metabolism ; Tryptophan Oxygenase</subject><ispartof>Chest, 1970-02, Vol.57 (2), p.148-150</ispartof><rights>1970 The American College of Chest Physicians</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c378t-49af1418523f835237f80c5c3a29eed9c105e5a8cb60d0f96c7d0bda3fc586d33</citedby><cites>FETCH-LOGICAL-c378t-49af1418523f835237f80c5c3a29eed9c105e5a8cb60d0f96c7d0bda3fc586d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5411715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Warraki, S.E.</creatorcontrib><creatorcontrib>El-Gammal, M.Y.</creatorcontrib><creatorcontrib>El-Asmar, M.F.</creatorcontrib><creatorcontrib>Wahba, N.</creatorcontrib><title>Serum Kynurenine in Bronchial Asthma and Chronic Bronchitis</title><title>Chest</title><addtitle>Chest</addtitle><description>Estimations of serum kynurenine were carried out in 20 normal Individuals, 20 patients with clinical evidence of chronic airway obstruction, and in 46 patients with airway obstruction in whom its presence and degree were also assessed by spirometry. The selection of patients was based on avoiding any possible cause of elevated serum kynurenine, at the same time ensuring a satisfactory state of nutrition, as well as normal liver function. The serum kynurenine mean value of the normal individuals was ± SD = 10 ± 2.29 mg percent. In the 20 patients with clinical evidence of chronic airway obstruction (no spirometry), all except one had higher serum kynurenine than the normal subjects. Of the 46 patients with clinical and spirometric evidence of chronic airway obstruction, 32 (69.6 percent) had high serum kynurenine values which were correlated with their indirect maximum breathing capacities.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Asthma - blood</subject><subject>Bronchitis - blood</subject><subject>Cortisone - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Kynurenine - blood</subject><subject>Male</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Nicotinic Acids - biosynthesis</subject><subject>Protein Biosynthesis</subject><subject>Serotonin - biosynthesis</subject><subject>Spirometry</subject><subject>Tryptophan - metabolism</subject><subject>Tryptophan Oxygenase</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtPxCAURonRjONj686kK3etUEpL42qc-IqTuFDXhIFby6SlI7Sa-feiHR8bNxDg-04uB6ETghNCC36uavB9wookTUjGd9CUlJTElGV0F00xJmlM8zLdRwfer3A4kzKfoAnLCCkIm6KLR3BDG91v7ODAGguRsdGl66yqjWyime_rVkbS6mheh1ujvh9744_QXiUbD8fb_RA9X189zW_jxcPN3Xy2iFUYsI-zUlYkI5yltOI0rEXFsWKKyrQE0KUimAGTXC1zrHFV5qrQeKklrRTjuab0EJ2N3LXrXofwXdEar6BppIVu8IJnWZEXvAzBZAwq13nvoBJrZ1rpNoJg8WlLfNkSrBCpCLZC4XRLHpYt6J_4Vs8vsDYv9btxIHwrmyak6YhadYOzsvkD5GMBgo83A054ZcAq0KGseqE7898sHz78ijU</recordid><startdate>197002</startdate><enddate>197002</enddate><creator>Warraki, S.E.</creator><creator>El-Gammal, M.Y.</creator><creator>El-Asmar, M.F.</creator><creator>Wahba, N.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197002</creationdate><title>Serum Kynurenine in Bronchial Asthma and Chronic Bronchitis</title><author>Warraki, S.E. ; El-Gammal, M.Y. ; El-Asmar, M.F. ; Wahba, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-49af1418523f835237f80c5c3a29eed9c105e5a8cb60d0f96c7d0bda3fc586d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Asthma - blood</topic><topic>Bronchitis - blood</topic><topic>Cortisone - pharmacology</topic><topic>Female</topic><topic>Humans</topic><topic>Kynurenine - blood</topic><topic>Male</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Nicotinic Acids - biosynthesis</topic><topic>Protein Biosynthesis</topic><topic>Serotonin - biosynthesis</topic><topic>Spirometry</topic><topic>Tryptophan - metabolism</topic><topic>Tryptophan Oxygenase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Warraki, S.E.</creatorcontrib><creatorcontrib>El-Gammal, M.Y.</creatorcontrib><creatorcontrib>El-Asmar, M.F.</creatorcontrib><creatorcontrib>Wahba, N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Warraki, S.E.</au><au>El-Gammal, M.Y.</au><au>El-Asmar, M.F.</au><au>Wahba, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Kynurenine in Bronchial Asthma and Chronic Bronchitis</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1970-02</date><risdate>1970</risdate><volume>57</volume><issue>2</issue><spage>148</spage><epage>150</epage><pages>148-150</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><abstract>Estimations of serum kynurenine were carried out in 20 normal Individuals, 20 patients with clinical evidence of chronic airway obstruction, and in 46 patients with airway obstruction in whom its presence and degree were also assessed by spirometry. The selection of patients was based on avoiding any possible cause of elevated serum kynurenine, at the same time ensuring a satisfactory state of nutrition, as well as normal liver function. The serum kynurenine mean value of the normal individuals was ± SD = 10 ± 2.29 mg percent. In the 20 patients with clinical evidence of chronic airway obstruction (no spirometry), all except one had higher serum kynurenine than the normal subjects. Of the 46 patients with clinical and spirometric evidence of chronic airway obstruction, 32 (69.6 percent) had high serum kynurenine values which were correlated with their indirect maximum breathing capacities.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>5411715</pmid><doi>10.1378/chest.57.2.148</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-3692 |
| ispartof | Chest, 1970-02, Vol.57 (2), p.148-150 |
| issn | 0012-3692 1931-3543 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Asthma - blood Bronchitis - blood Cortisone - pharmacology Female Humans Kynurenine - blood Male Methods Middle Aged Nicotinic Acids - biosynthesis Protein Biosynthesis Serotonin - biosynthesis Spirometry Tryptophan - metabolism Tryptophan Oxygenase |
| title | Serum Kynurenine in Bronchial Asthma and Chronic Bronchitis |
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