Gas chromatographic determination of iodinated compounds
The qualitative and quantitative gas chromatographic evaluation of a large variety of iodinated substances (iodoamino acids and their side chain and position analogs, intermediates in the synthesis or degradation of the thyroid hormones, and related compounds) is described. As little as a few hundre...
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| Veröffentlicht in: | Analytical biochemistry 1969, Vol.27 (1), p.150-161 |
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| container_title | Analytical biochemistry |
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| creator | Funakoshi, Kazuhisa Cahnmann, H.J. |
| description | The qualitative and quantitative gas chromatographic evaluation of a large variety of iodinated substances (iodoamino acids and their side chain and position analogs, intermediates in the synthesis or degradation of the thyroid hormones, and related compounds) is described. As little as a few hundred picograms can be determined accurately in most cases by means of an electron capture detector. Nonvolatile compounds have been converted to their volatile trimethylsilyl derivatives by treatment with
N,O-bis(trimethylsilyl)acetamide at room temperature or at 80°. Various characteristics of these derivatives as well as precautions which must be taken for the determination of picogram and nanogram amounts are described. Mass spectrometry shows that the gas chromatographically determined derivatives of the iodoamino acids contain three trimethylsilyl groups. |
| doi_str_mv | 10.1016/0003-2697(69)90226-7 |
| format | Article |
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N,O-bis(trimethylsilyl)acetamide at room temperature or at 80°. Various characteristics of these derivatives as well as precautions which must be taken for the determination of picogram and nanogram amounts are described. Mass spectrometry shows that the gas chromatographically determined derivatives of the iodoamino acids contain three trimethylsilyl groups.</description><identifier>ISSN: 0003-2697</identifier><identifier>EISSN: 1096-0309</identifier><identifier>DOI: 10.1016/0003-2697(69)90226-7</identifier><identifier>PMID: 5397235</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acids - analysis ; Chromatography, Gas ; Diiodotyrosine - analysis ; Iodine ; Methods ; Microchemistry ; Monoiodotyrosine - analysis ; Silicon ; Spectrum Analysis ; Thyroid Hormones - analysis ; Thyroxine - analysis ; Triiodothyronine - analysis ; Tyrosine - analysis</subject><ispartof>Analytical biochemistry, 1969, Vol.27 (1), p.150-161</ispartof><rights>1968</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-8dd16cfc6d889f6c2fc9790b910e7aa7379729468af26b3777249d90e292352b3</citedby><cites>FETCH-LOGICAL-c423t-8dd16cfc6d889f6c2fc9790b910e7aa7379729468af26b3777249d90e292352b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0003269769902267$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5397235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Funakoshi, Kazuhisa</creatorcontrib><creatorcontrib>Cahnmann, H.J.</creatorcontrib><title>Gas chromatographic determination of iodinated compounds</title><title>Analytical biochemistry</title><addtitle>Anal Biochem</addtitle><description>The qualitative and quantitative gas chromatographic evaluation of a large variety of iodinated substances (iodoamino acids and their side chain and position analogs, intermediates in the synthesis or degradation of the thyroid hormones, and related compounds) is described. As little as a few hundred picograms can be determined accurately in most cases by means of an electron capture detector. Nonvolatile compounds have been converted to their volatile trimethylsilyl derivatives by treatment with
N,O-bis(trimethylsilyl)acetamide at room temperature or at 80°. Various characteristics of these derivatives as well as precautions which must be taken for the determination of picogram and nanogram amounts are described. Mass spectrometry shows that the gas chromatographically determined derivatives of the iodoamino acids contain three trimethylsilyl groups.</description><subject>Amino Acids - analysis</subject><subject>Chromatography, Gas</subject><subject>Diiodotyrosine - analysis</subject><subject>Iodine</subject><subject>Methods</subject><subject>Microchemistry</subject><subject>Monoiodotyrosine - analysis</subject><subject>Silicon</subject><subject>Spectrum Analysis</subject><subject>Thyroid Hormones - analysis</subject><subject>Thyroxine - analysis</subject><subject>Triiodothyronine - analysis</subject><subject>Tyrosine - analysis</subject><issn>0003-2697</issn><issn>1096-0309</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo67r6DxR6Ej1U89WkuQiy-AULXvQc0mTqRrZNTVrBf2_rLnv0NAzvO-_MPAidE3xDMBG3GGOWU6HklVDXClMqcnmA5gQrkWOG1SGa7y3H6CSlT4wJ4YWYoVnBlKSsmKPyyaTMrmNoTB8-ounW3mYOeoiNb03vQ5uFOvPBTR24zIamC0Pr0ik6qs0mwdmuLtD748Pb8jlfvT69LO9XueWU9XnpHBG2tsKVpaqFpbVVUuFKEQzSGMnkeIjiojQ1FRWTUlKunMJA1XgfrdgCXW5zuxi-Bki9bnyysNmYFsKQdMm5LAQho5FvjTaGlCLUuou-MfFHE6wnYHqioScaWij9B0zLcexilz9UDbj90I7QqN9tdRif_PYQdbIeWgvOR7C9dsH_v-AXcgt5OQ</recordid><startdate>1969</startdate><enddate>1969</enddate><creator>Funakoshi, Kazuhisa</creator><creator>Cahnmann, H.J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1969</creationdate><title>Gas chromatographic determination of iodinated compounds</title><author>Funakoshi, Kazuhisa ; Cahnmann, H.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-8dd16cfc6d889f6c2fc9790b910e7aa7379729468af26b3777249d90e292352b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Amino Acids - analysis</topic><topic>Chromatography, Gas</topic><topic>Diiodotyrosine - analysis</topic><topic>Iodine</topic><topic>Methods</topic><topic>Microchemistry</topic><topic>Monoiodotyrosine - analysis</topic><topic>Silicon</topic><topic>Spectrum Analysis</topic><topic>Thyroid Hormones - analysis</topic><topic>Thyroxine - analysis</topic><topic>Triiodothyronine - analysis</topic><topic>Tyrosine - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Funakoshi, Kazuhisa</creatorcontrib><creatorcontrib>Cahnmann, H.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Funakoshi, Kazuhisa</au><au>Cahnmann, H.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gas chromatographic determination of iodinated compounds</atitle><jtitle>Analytical biochemistry</jtitle><addtitle>Anal Biochem</addtitle><date>1969</date><risdate>1969</risdate><volume>27</volume><issue>1</issue><spage>150</spage><epage>161</epage><pages>150-161</pages><issn>0003-2697</issn><eissn>1096-0309</eissn><abstract>The qualitative and quantitative gas chromatographic evaluation of a large variety of iodinated substances (iodoamino acids and their side chain and position analogs, intermediates in the synthesis or degradation of the thyroid hormones, and related compounds) is described. As little as a few hundred picograms can be determined accurately in most cases by means of an electron capture detector. Nonvolatile compounds have been converted to their volatile trimethylsilyl derivatives by treatment with
N,O-bis(trimethylsilyl)acetamide at room temperature or at 80°. Various characteristics of these derivatives as well as precautions which must be taken for the determination of picogram and nanogram amounts are described. Mass spectrometry shows that the gas chromatographically determined derivatives of the iodoamino acids contain three trimethylsilyl groups.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>5397235</pmid><doi>10.1016/0003-2697(69)90226-7</doi><tpages>12</tpages></addata></record> |
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| ispartof | Analytical biochemistry, 1969, Vol.27 (1), p.150-161 |
| issn | 0003-2697 1096-0309 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84475611 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acids - analysis Chromatography, Gas Diiodotyrosine - analysis Iodine Methods Microchemistry Monoiodotyrosine - analysis Silicon Spectrum Analysis Thyroid Hormones - analysis Thyroxine - analysis Triiodothyronine - analysis Tyrosine - analysis |
| title | Gas chromatographic determination of iodinated compounds |
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