Immune response to urinary bladder tumours in man
A microassay in disposable tissue culture plates was used to demonstrate a cell‐mediated immune response against human urinary bladder carcinoma. Leukocytes isolated from peripheral blood of patients with urinary bladder tumours were allowed to react in vitro with cells of bladder tumours, or with a...
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| Veröffentlicht in: | International journal of cancer 1970-01, Vol.5 (1), p.39-46 |
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| container_title | International journal of cancer |
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| creator | Bubenïk, J. Perlmann, P. Helmstein, K. Moberger, G. |
| description | A microassay in disposable tissue culture plates was used to demonstrate a cell‐mediated immune response against human urinary bladder carcinoma. Leukocytes isolated from peripheral blood of patients with urinary bladder tumours were allowed to react in vitro with cells of bladder tumours, or with a control tumour or normal cells. Both autochthonous and allogeneic leukocytes from patients with bladder tumours strongly reduced the number of plated bladder tumour cells as compared to control leukocytes, but did not affect control tumour or normal cells. No significant cytotoxic effects were produced by control leukocyte suspensions from a patient with prostatic carcinoma, from patients with non‐neoplastic diseases or from normal healthy individuals.
The results indicate that human urinary bladder tumours possess tumour‐specific antigens which cross‐react with each other. |
| doi_str_mv | 10.1002/ijc.2910050106 |
| format | Article |
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The results indicate that human urinary bladder tumours possess tumour‐specific antigens which cross‐react with each other.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antigens</subject><subject>Culture Techniques</subject><subject>Female</subject><subject>Humans</subject><subject>Leukocytes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Urinary Bladder Neoplasms - blood</subject><subject>Urinary Bladder Neoplasms - immunology</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1970</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUE1LAzEUDKLUWr16E3LytvW9JJt2j7L4USl40XPIJlnYstmtSYP03xtpUW--y_uYeQMzhFwjzBGA3XUbM2dVHktAkCdkilAtCmBYnpJpJkCxQC7PyUWMGwDEEsSETEqBYiHYlODK-zQ4GlzcjkN0dDfSFLpBhz1tem2tC3SX_JhCpN1AvR4uyVmr--iujn1G3h8f3urnYv36tKrv14XhspLFUjoujEPeomTaMNs0glk0PFfVamDcYsMkayubVwnGtcYakw8IwkjgM3J70N2G8SO5uFO-i8b1vR7cmKJaiuyAZ3MzMj8QTRhjDK5V29D5bEAhqO-MVM5I_WaUH26Oyqnxzv7Qj6FkvDrgn13v9v-oqdVL_Uf7C145ceI</recordid><startdate>19700115</startdate><enddate>19700115</enddate><creator>Bubenïk, J.</creator><creator>Perlmann, P.</creator><creator>Helmstein, K.</creator><creator>Moberger, G.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19700115</creationdate><title>Immune response to urinary bladder tumours in man</title><author>Bubenïk, J. ; Perlmann, P. ; Helmstein, K. ; Moberger, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3696-86e34ce13f162ac2dbb42d1c33339fa023d1b262f9d9fa60cefcdcc62f104c603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1970</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antigens</topic><topic>Culture Techniques</topic><topic>Female</topic><topic>Humans</topic><topic>Leukocytes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Urinary Bladder Neoplasms - blood</topic><topic>Urinary Bladder Neoplasms - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bubenïk, J.</creatorcontrib><creatorcontrib>Perlmann, P.</creatorcontrib><creatorcontrib>Helmstein, K.</creatorcontrib><creatorcontrib>Moberger, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bubenïk, J.</au><au>Perlmann, P.</au><au>Helmstein, K.</au><au>Moberger, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune response to urinary bladder tumours in man</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>1970-01-15</date><risdate>1970</risdate><volume>5</volume><issue>1</issue><spage>39</spage><epage>46</epage><pages>39-46</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><abstract>A microassay in disposable tissue culture plates was used to demonstrate a cell‐mediated immune response against human urinary bladder carcinoma. Leukocytes isolated from peripheral blood of patients with urinary bladder tumours were allowed to react in vitro with cells of bladder tumours, or with a control tumour or normal cells. Both autochthonous and allogeneic leukocytes from patients with bladder tumours strongly reduced the number of plated bladder tumour cells as compared to control leukocytes, but did not affect control tumour or normal cells. No significant cytotoxic effects were produced by control leukocyte suspensions from a patient with prostatic carcinoma, from patients with non‐neoplastic diseases or from normal healthy individuals.
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| identifier | ISSN: 0020-7136 |
| ispartof | International journal of cancer, 1970-01, Vol.5 (1), p.39-46 |
| issn | 0020-7136 1097-0215 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Adolescent Adult Aged Antigens Culture Techniques Female Humans Leukocytes Male Middle Aged Urinary Bladder Neoplasms - blood Urinary Bladder Neoplasms - immunology |
| title | Immune response to urinary bladder tumours in man |
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