The metabolism and production rate of estradiol-17β in premenopausal women with cervical carcinoma

Radioactive estradiol-17β was injected into premenopausal women with cervical carcinoma and healthy controls after which all urine was collected for 5 days and assayed for estrone (E1), estradiol (E2), estriol (E3), and radioactivity associated with these fractions. Endogenous E2 production rates we...

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Veröffentlicht in:	American journal of obstetrics and gynecology 1967-06, Vol.98 (4), p.509-515
Hauptverfasser:	Fraser, R.C., Cudmore, D.C., Melanson, J., Morse, W.I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Carcinoma - urine Estradiol - urine Estriol - biosynthesis Estriol - urine Estrone - urine Female Humans Middle Aged Tritium Uterine Cervical Neoplasms - etiology Uterine Cervical Neoplasms - urine
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container_end_page	515
container_issue	4
container_start_page	509
container_title	American journal of obstetrics and gynecology
container_volume	98
creator	Fraser, R.C. Cudmore, D.C. Melanson, J. Morse, W.I.
description	Radioactive estradiol-17β was injected into premenopausal women with cervical carcinoma and healthy controls after which all urine was collected for 5 days and assayed for estrone (E1), estradiol (E2), estriol (E3), and radioactivity associated with these fractions. Endogenous E2 production rates were calculated from the results of these assays. The younger control group (mean age, 30 years) excreted more E1 and had higher E1:E3 and E2:E3 ratios than the older controls (mean age, 45 years). The patients with carcinoma had lower mean E1:E3 and E2:E3 ratios and excreted less of the injected radioactivity in the E1 and E2 fractions than the controls. The mean E2 production rate was increased in the women with Stage 0 carcinoma. The significance of these findings, including the possibility that increased estrogen production (or a relative increase in E3 production) fostered the development of the initial stages of cervical carcinoma, has been discussed
doi_str_mv	10.1016/0002-9378(67)90104-4
format	Article
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Endogenous E2 production rates were calculated from the results of these assays. The younger control group (mean age, 30 years) excreted more E1 and had higher E1:E3 and E2:E3 ratios than the older controls (mean age, 45 years). The patients with carcinoma had lower mean E1:E3 and E2:E3 ratios and excreted less of the injected radioactivity in the E1 and E2 fractions than the controls. The mean E2 production rate was increased in the women with Stage 0 carcinoma. 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The significance of these findings, including the possibility that increased estrogen production (or a relative increase in E3 production) fostered the development of the initial stages of cervical carcinoma, has been discussed</description><subject>Adult</subject><subject>Carcinoma - urine</subject><subject>Estradiol - urine</subject><subject>Estriol - biosynthesis</subject><subject>Estriol - urine</subject><subject>Estrone - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Tritium</subject><subject>Uterine Cervical Neoplasms - etiology</subject><subject>Uterine Cervical Neoplasms - urine</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlKBDEQhoMo47i8gUJOoofWpJek-yKIuIHgZTyHdKWCke7OmHQrvpYP4jOZcQaPnoqq-mv5P0KOODvnjIsLxlieNYWsT4U8axhnZVZukTlnjcxELeptMv-T7JK9GF9Xad7kMzITLK94Wc0JLF6Q9jjq1ncu9lQPhi6DNxOMzg806BGptxTjGLRxvsu4_P6ibkgi7HHwSz1F3dEPnxL64cYXChjeHaQa6ABu8L0-IDtWdxEPN3GfPN_eLK7vs8enu4frq8cMcpmPma4M8AqxaaWQFk1hSzCFbAsr6lrXDeatYQzboqnqItngFlpRSTCtZdY0UOyTk_XeZOBtSi-r3kXArtMD-imquiwrwQqZhOVaCMHHGNCqZXC9Dp-KM7Viq1ak1AqcElL9slVlGjve7J_aHs3f0AZm6l-u-5hMvjsMKoLDAdC4gDAq493_B34AAw6LGw</recordid><startdate>19670615</startdate><enddate>19670615</enddate><creator>Fraser, R.C.</creator><creator>Cudmore, D.C.</creator><creator>Melanson, J.</creator><creator>Morse, W.I.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19670615</creationdate><title>The metabolism and production rate of estradiol-17β in premenopausal women with cervical carcinoma</title><author>Fraser, R.C. ; Cudmore, D.C. ; Melanson, J. ; Morse, W.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-a5dc15ee9b767fed3f4cd37b3f688a89e2bd00eb395832921fcb657cdbf0fd9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Adult</topic><topic>Carcinoma - urine</topic><topic>Estradiol - urine</topic><topic>Estriol - biosynthesis</topic><topic>Estriol - urine</topic><topic>Estrone - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Tritium</topic><topic>Uterine Cervical Neoplasms - etiology</topic><topic>Uterine Cervical Neoplasms - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fraser, R.C.</creatorcontrib><creatorcontrib>Cudmore, D.C.</creatorcontrib><creatorcontrib>Melanson, J.</creatorcontrib><creatorcontrib>Morse, W.I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fraser, R.C.</au><au>Cudmore, D.C.</au><au>Melanson, J.</au><au>Morse, W.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The metabolism and production rate of estradiol-17β in premenopausal women with cervical carcinoma</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1967-06-15</date><risdate>1967</risdate><volume>98</volume><issue>4</issue><spage>509</spage><epage>515</epage><pages>509-515</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>Radioactive estradiol-17β was injected into premenopausal women with cervical carcinoma and healthy controls after which all urine was collected for 5 days and assayed for estrone (E1), estradiol (E2), estriol (E3), and radioactivity associated with these fractions. Endogenous E2 production rates were calculated from the results of these assays. The younger control group (mean age, 30 years) excreted more E1 and had higher E1:E3 and E2:E3 ratios than the older controls (mean age, 45 years). The patients with carcinoma had lower mean E1:E3 and E2:E3 ratios and excreted less of the injected radioactivity in the E1 and E2 fractions than the controls. The mean E2 production rate was increased in the women with Stage 0 carcinoma. The significance of these findings, including the possibility that increased estrogen production (or a relative increase in E3 production) fostered the development of the initial stages of cervical carcinoma, has been discussed</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6025145</pmid><doi>10.1016/0002-9378(67)90104-4</doi><tpages>7</tpages></addata></record>
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source	MEDLINE; Elsevier ScienceDirect Journals
subjects	Adult Carcinoma - urine Estradiol - urine Estriol - biosynthesis Estriol - urine Estrone - urine Female Humans Middle Aged Tritium Uterine Cervical Neoplasms - etiology Uterine Cervical Neoplasms - urine
title	The metabolism and production rate of estradiol-17β in premenopausal women with cervical carcinoma
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