THE INFLUENCE OF DRUGS USED IN NEUROLEPTANALGESIA ON CARDIOVASCULAR AND VENTILATORY FUNCTION
The circulatory and ventilatory influences of various combinations of the narcotic analgesics phenoperidine and fentanyl, and the neuroleptics haloperidol and dehydrobenzperidol, were investigated during nitrous oxide anaesthesia in 230 patients. Measurements of cardiac output and other haemodynamic...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1967-02, Vol.39 (2), p.134-145 |
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| container_title | British journal of anaesthesia : BJA |
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| creator | PRYS-ROBERTS, C. KELMAN, G.R. |
| description | The circulatory and ventilatory influences of various combinations of the narcotic analgesics phenoperidine and fentanyl, and the neuroleptics haloperidol and dehydrobenzperidol, were investigated during nitrous oxide anaesthesia in 230 patients. Measurements of cardiac output and other haemodynamic variables in nine patients supported the general findings that the cardiovascular effects of the analgesics were modified by alterations of ventilation, in particular the haemodynamic effects of concurrent hypercapnia. Serious circulatory disturbances were not found following premedication with neuroleptic drugs. Mechanisms of ventilatory depression following the use of the analgesics have been evaluated, and indices of ventilation and arterial oxygenation show that postoperative values after neuroleptanalgesia are comparable to those after other methods of anaesthesia. The rationale of neuroleptanalgesia combined with light general anaesthesia is explored and the pharmacology of the drugs is reviewed. |
| doi_str_mv | 10.1093/bja/39.2.134 |
| format | Article |
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The rationale of neuroleptanalgesia combined with light general anaesthesia is explored and the pharmacology of the drugs is reviewed.</description><subject>Acid-Base Equilibrium</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia</subject><subject>Benperidol - pharmacology</subject><subject>Blood Gas Analysis</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiac Output - drug effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Fentanyl - pharmacology</subject><subject>Haloperidol - pharmacology</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuroleptanalgesia</subject><subject>Phenoperidine - pharmacology</subject><subject>Respiration - drug effects</subject><subject>Respiratory Function Tests</subject><subject>Spirometry</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1967</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMFr2zAUh8XY6LJut10HOu00p0-ybNlH4SiJFyMXxy7bGAjZlsFd0nRWMtr_fhoJPe304P0-frz3IfSRwJxAGt609-YmTOd0TkL2Cs0I4ySIOSev0QwAeAApoW_RO-fuAQinaXSFrmKghER8hn7Wa4lztSwaqTKJyyVeVM1qi5utXPg9VrKpykLe1kKJYiW3ucClwpmoFnl5J7ZZU4gKC7XAd1LVeSHqsvqOl43K6rxU79Gbweyc_XCZ16hZyjpbB0W5yjNRBB2D9BjEne0TwtqW2xSSOGVgCOUdi3oeR0PIewuJbUNioIsGbkxi4xbokFAzJL2hfXiNPp97H6fD75N1R70fXWd3O_NgDyenE8aYfz3y4Jcz2E0H5yY76Mdp3JvpWRPQ_2RqL1OHqabay_T4p0vvqd3b_gW-2PN5cM5Hd7RPL7GZfumYhzzS628_9O1ms0lAUf3V8_GZt17Gn9FO2nWjffDvj5Ptjro_jP8_5C_Jmol4</recordid><startdate>196702</startdate><enddate>196702</enddate><creator>PRYS-ROBERTS, C.</creator><creator>KELMAN, G.R.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196702</creationdate><title>THE INFLUENCE OF DRUGS USED IN NEUROLEPTANALGESIA ON CARDIOVASCULAR AND VENTILATORY FUNCTION</title><author>PRYS-ROBERTS, C. ; KELMAN, G.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-6ced814bb7e9086940a127c45d765f37de08eb31a0c5f7aa8e6b02f82af8da2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1967</creationdate><topic>Acid-Base Equilibrium</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia</topic><topic>Benperidol - pharmacology</topic><topic>Blood Gas Analysis</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiac Output - drug effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Fentanyl - pharmacology</topic><topic>Haloperidol - pharmacology</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuroleptanalgesia</topic><topic>Phenoperidine - pharmacology</topic><topic>Respiration - drug effects</topic><topic>Respiratory Function Tests</topic><topic>Spirometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PRYS-ROBERTS, C.</creatorcontrib><creatorcontrib>KELMAN, G.R.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PRYS-ROBERTS, C.</au><au>KELMAN, G.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THE INFLUENCE OF DRUGS USED IN NEUROLEPTANALGESIA ON CARDIOVASCULAR AND VENTILATORY FUNCTION</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>1967-02</date><risdate>1967</risdate><volume>39</volume><issue>2</issue><spage>134</spage><epage>145</epage><pages>134-145</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><abstract>The circulatory and ventilatory influences of various combinations of the narcotic analgesics phenoperidine and fentanyl, and the neuroleptics haloperidol and dehydrobenzperidol, were investigated during nitrous oxide anaesthesia in 230 patients. Measurements of cardiac output and other haemodynamic variables in nine patients supported the general findings that the cardiovascular effects of the analgesics were modified by alterations of ventilation, in particular the haemodynamic effects of concurrent hypercapnia. Serious circulatory disturbances were not found following premedication with neuroleptic drugs. Mechanisms of ventilatory depression following the use of the analgesics have been evaluated, and indices of ventilation and arterial oxygenation show that postoperative values after neuroleptanalgesia are comparable to those after other methods of anaesthesia. The rationale of neuroleptanalgesia combined with light general anaesthesia is explored and the pharmacology of the drugs is reviewed.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>6021157</pmid><doi>10.1093/bja/39.2.134</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of anaesthesia : BJA, 1967-02, Vol.39 (2), p.134-145 |
| issn | 0007-0912 1471-6771 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals Digital Archive Legacy; Alma/SFX Local Collection |
| subjects | Acid-Base Equilibrium Adolescent Adult Aged Anesthesia Benperidol - pharmacology Blood Gas Analysis Blood Pressure - drug effects Cardiac Output - drug effects Child Child, Preschool Female Fentanyl - pharmacology Haloperidol - pharmacology Heart Rate - drug effects Humans Male Middle Aged Neuroleptanalgesia Phenoperidine - pharmacology Respiration - drug effects Respiratory Function Tests Spirometry |
| title | THE INFLUENCE OF DRUGS USED IN NEUROLEPTANALGESIA ON CARDIOVASCULAR AND VENTILATORY FUNCTION |
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