The behavioural, cardiovascular and respiratory actions of morphine-N-oxide in the dog
A comparison between the actions of morphine and morphine- N-oxide (MNO) on behaviour, blood pressure, heart rate and respiration of both conscious and anaesthetised dogs has been studied. In the conscious dog morphine was more potent than MNO in producing sedation when both drugs were given subcuta...
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| Veröffentlicht in: | European journal of pharmacology 1969-12, Vol.8 (3), p.261-268 |
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| container_title | European journal of pharmacology |
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| creator | Fennessy, M.R. |
| description | A comparison between the actions of morphine and morphine-
N-oxide (MNO) on behaviour, blood pressure, heart rate and respiration of both conscious and anaesthetised dogs has been studied. In the conscious dog morphine was more potent than MNO in producing sedation when both drugs were given subcutaneously. MNO had no antimorphine activity. Intravenously administered morphine or MNO caused sham rage, tachycardia and an increased respiratory rate in the conscious dog. Morphine was more potent than MNO in producing these actions. The effects of these drugs on the blood pressure of conscious dogs varied; all doses of morphine caused pressor response, whereas small doses of MNO produced pressor responses while larger doses cause depressor responses. In the anaesthetised dog intravenous injections of morphine or MNO produced biphasic depressor responses, bradycardia and decreased respiratory rate. Any difference in activity between these drugs may be due to morphine having a greater ease of entry into the brain than MNO. |
| doi_str_mv | 10.1016/0014-2999(69)90034-X |
| format | Article |
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N-oxide (MNO) on behaviour, blood pressure, heart rate and respiration of both conscious and anaesthetised dogs has been studied. In the conscious dog morphine was more potent than MNO in producing sedation when both drugs were given subcutaneously. MNO had no antimorphine activity. Intravenously administered morphine or MNO caused sham rage, tachycardia and an increased respiratory rate in the conscious dog. Morphine was more potent than MNO in producing these actions. The effects of these drugs on the blood pressure of conscious dogs varied; all doses of morphine caused pressor response, whereas small doses of MNO produced pressor responses while larger doses cause depressor responses. In the anaesthetised dog intravenous injections of morphine or MNO produced biphasic depressor responses, bradycardia and decreased respiratory rate. Any difference in activity between these drugs may be due to morphine having a greater ease of entry into the brain than MNO.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(69)90034-X</identifier><identifier>PMID: 4391827</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Acridines - pharmacology ; Anaesthetised dog ; Animals ; Arousal - drug effects ; Atropine - pharmacology ; Behavior, Animal - drug effects ; Behaviour ; Blood Pressure - drug effects ; Cardiovascular ; Cardiovascular System - drug effects ; Carotid Arteries - drug effects ; Conscious dog ; Cyclic N-Oxides - pharmacology ; Dogs ; Heart Rate - drug effects ; Histamine H1 Antagonists - pharmacology ; Injections, Intravenous ; Injections, Subcutaneous ; Morphinans - administration & dosage ; Morphinans - pharmacology ; Morphine ; Morphine - administration & dosage ; Morphine - pharmacology ; Morphine- N-oxide ; Nalorphine - pharmacology ; Pyridines - pharmacology ; Respiration - drug effects ; Thiazoles - pharmacology</subject><ispartof>European journal of pharmacology, 1969-12, Vol.8 (3), p.261-268</ispartof><rights>1969</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-2091789e2e6fe86c47a22eda2c66ab3420296572c39be4054cca43a18e1d2b93</citedby><cites>FETCH-LOGICAL-c357t-2091789e2e6fe86c47a22eda2c66ab3420296572c39be4054cca43a18e1d2b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/001429996990034X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4391827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fennessy, M.R.</creatorcontrib><title>The behavioural, cardiovascular and respiratory actions of morphine-N-oxide in the dog</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>A comparison between the actions of morphine and morphine-
N-oxide (MNO) on behaviour, blood pressure, heart rate and respiration of both conscious and anaesthetised dogs has been studied. In the conscious dog morphine was more potent than MNO in producing sedation when both drugs were given subcutaneously. MNO had no antimorphine activity. Intravenously administered morphine or MNO caused sham rage, tachycardia and an increased respiratory rate in the conscious dog. Morphine was more potent than MNO in producing these actions. The effects of these drugs on the blood pressure of conscious dogs varied; all doses of morphine caused pressor response, whereas small doses of MNO produced pressor responses while larger doses cause depressor responses. In the anaesthetised dog intravenous injections of morphine or MNO produced biphasic depressor responses, bradycardia and decreased respiratory rate. Any difference in activity between these drugs may be due to morphine having a greater ease of entry into the brain than MNO.</description><subject>Acridines - pharmacology</subject><subject>Anaesthetised dog</subject><subject>Animals</subject><subject>Arousal - drug effects</subject><subject>Atropine - pharmacology</subject><subject>Behavior, Animal - drug effects</subject><subject>Behaviour</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular</subject><subject>Cardiovascular System - drug effects</subject><subject>Carotid Arteries - drug effects</subject><subject>Conscious dog</subject><subject>Cyclic N-Oxides - pharmacology</subject><subject>Dogs</subject><subject>Heart Rate - drug effects</subject><subject>Histamine H1 Antagonists - pharmacology</subject><subject>Injections, Intravenous</subject><subject>Injections, Subcutaneous</subject><subject>Morphinans - administration & dosage</subject><subject>Morphinans - pharmacology</subject><subject>Morphine</subject><subject>Morphine - administration & dosage</subject><subject>Morphine - pharmacology</subject><subject>Morphine- N-oxide</subject><subject>Nalorphine - pharmacology</subject><subject>Pyridines - pharmacology</subject><subject>Respiration - drug effects</subject><subject>Thiazoles - pharmacology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LwzAYx4Moc06_gUJOomA1SdO0uQgyfIOhlyG7hTR56iJdM5N2uG9v58aOnp7D_43nh9A5JbeUUHFHCOUJk1JeCXktCUl5MjtAQ1rkMiE5ZYdouLcco5MYvwghmWTZAA14KmnB8iH6mM4BlzDXK-e7oOsbbHSwzq90NF2tA9aNxQHi0gXd-rDG2rTONxH7Ci98WM5dA8lb4n-cBewa3PZ11n-eoqNK1xHOdneEpk-P0_FLMnl_fh0_TBKTZnmbMCJpXkhgICoohOG5ZgysZkYIXaacESZFljOTyhI4ybgxmqeaFkAtK2U6Qpfb2mXw3x3EVi1cNFDXugHfRVXwtChykfVGvjWa4GMMUKllcAsd1ooStaGpNqjUBpUSUv3RVLM-drHr78oF2H1oh6_X77c69D-uHAQVjYPGgHUBTKusd_8P_AJxLoQ9</recordid><startdate>196912</startdate><enddate>196912</enddate><creator>Fennessy, M.R.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196912</creationdate><title>The behavioural, cardiovascular and respiratory actions of morphine-N-oxide in the dog</title><author>Fennessy, M.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-2091789e2e6fe86c47a22eda2c66ab3420296572c39be4054cca43a18e1d2b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Acridines - pharmacology</topic><topic>Anaesthetised dog</topic><topic>Animals</topic><topic>Arousal - drug effects</topic><topic>Atropine - pharmacology</topic><topic>Behavior, Animal - drug effects</topic><topic>Behaviour</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular</topic><topic>Cardiovascular System - drug effects</topic><topic>Carotid Arteries - drug effects</topic><topic>Conscious dog</topic><topic>Cyclic N-Oxides - pharmacology</topic><topic>Dogs</topic><topic>Heart Rate - drug effects</topic><topic>Histamine H1 Antagonists - pharmacology</topic><topic>Injections, Intravenous</topic><topic>Injections, Subcutaneous</topic><topic>Morphinans - administration & dosage</topic><topic>Morphinans - pharmacology</topic><topic>Morphine</topic><topic>Morphine - administration & dosage</topic><topic>Morphine - pharmacology</topic><topic>Morphine- N-oxide</topic><topic>Nalorphine - pharmacology</topic><topic>Pyridines - pharmacology</topic><topic>Respiration - drug effects</topic><topic>Thiazoles - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fennessy, M.R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fennessy, M.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The behavioural, cardiovascular and respiratory actions of morphine-N-oxide in the dog</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1969-12</date><risdate>1969</risdate><volume>8</volume><issue>3</issue><spage>261</spage><epage>268</epage><pages>261-268</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>A comparison between the actions of morphine and morphine-
N-oxide (MNO) on behaviour, blood pressure, heart rate and respiration of both conscious and anaesthetised dogs has been studied. In the conscious dog morphine was more potent than MNO in producing sedation when both drugs were given subcutaneously. MNO had no antimorphine activity. Intravenously administered morphine or MNO caused sham rage, tachycardia and an increased respiratory rate in the conscious dog. Morphine was more potent than MNO in producing these actions. The effects of these drugs on the blood pressure of conscious dogs varied; all doses of morphine caused pressor response, whereas small doses of MNO produced pressor responses while larger doses cause depressor responses. In the anaesthetised dog intravenous injections of morphine or MNO produced biphasic depressor responses, bradycardia and decreased respiratory rate. Any difference in activity between these drugs may be due to morphine having a greater ease of entry into the brain than MNO.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>4391827</pmid><doi>10.1016/0014-2999(69)90034-X</doi><tpages>8</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1969-12, Vol.8 (3), p.261-268 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acridines - pharmacology Anaesthetised dog Animals Arousal - drug effects Atropine - pharmacology Behavior, Animal - drug effects Behaviour Blood Pressure - drug effects Cardiovascular Cardiovascular System - drug effects Carotid Arteries - drug effects Conscious dog Cyclic N-Oxides - pharmacology Dogs Heart Rate - drug effects Histamine H1 Antagonists - pharmacology Injections, Intravenous Injections, Subcutaneous Morphinans - administration & dosage Morphinans - pharmacology Morphine Morphine - administration & dosage Morphine - pharmacology Morphine- N-oxide Nalorphine - pharmacology Pyridines - pharmacology Respiration - drug effects Thiazoles - pharmacology |
| title | The behavioural, cardiovascular and respiratory actions of morphine-N-oxide in the dog |
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