Biochemical properties of anti-inflammatory drugs—VII. Inhibition of proteolytic enzymes in connective tissue by chloroquine (resochin) and related antimalarial/antirheumatic drugs

A chondromucoprotease present in bovine cartilage, with optimal activity at pH 5, has been partially characterized. This autolytic enzyme was irreversibly inhibited by chloroquine, those of its metabolites with a quinoline nucleus, and mepacrine (quinacrine, atebrine). These drugs did not affect car...

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Veröffentlicht in:	Biochemical pharmacology 1966-08, Vol.15 (8), p.1071-1084
Hauptverfasser:	Cowey, F.K., Whitehouse, M.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - pharmacology Animals Cartilage - metabolism Cattle Chloroquine - metabolism Chloroquine - pharmacology Chondroitin - metabolism Connective Tissue - metabolism Hyaluronoglucosaminidase - pharmacology Hydrogen-Ion Concentration Hydroxychloroquine - metabolism Microbial Collagenase - metabolism Mucoproteins - metabolism Papain - pharmacology Primaquine - pharmacology Quaternary Ammonium Compounds - pharmacology Quinacrine - pharmacology Rabbits
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