Structure and development of viruses as observed in the electron microscope. V. Entry and uncoating of adenovirus
Stages in the direct penetration of adenovirus through the cell membrane are illustrated. Phagocytosis with rupture of the vacuole and release of virus into the cytoplasm may also account for entry of some particles. Uncoating by digestion within phagosomes was not observed. Rather, alteration of ca...
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| Veröffentlicht in: | Journal of virology 1969-11, Vol.4 (5), p.777-796 |
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| container_end_page | 796 |
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| container_title | Journal of virology |
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| creator | Morgan, C Rosenkranz, H S Mednis, B |
| description | Stages in the direct penetration of adenovirus through the cell membrane are illustrated. Phagocytosis with rupture of the vacuole and release of virus into the cytoplasm may also account for entry of some particles. Uncoating by digestion within phagosomes was not observed. Rather, alteration of capsid and core occurred to virions free in the cytoplasm. Nucleoprotein released from virus close to the nucleus was transported to the nuclear matrix by a unique mechanism. These events were not prevented by puromycin and hence were not dependent upon the synthesis of new enzymes. They were, however, energy-dependent. |
| doi_str_mv | 10.1128/jvi.4.5.777-796.1969 |
| format | Article |
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V. Entry and uncoating of adenovirus</title><title>Journal of virology</title><addtitle>J Virol</addtitle><description>Stages in the direct penetration of adenovirus through the cell membrane are illustrated. Phagocytosis with rupture of the vacuole and release of virus into the cytoplasm may also account for entry of some particles. Uncoating by digestion within phagosomes was not observed. Rather, alteration of capsid and core occurred to virions free in the cytoplasm. Nucleoprotein released from virus close to the nucleus was transported to the nuclear matrix by a unique mechanism. These events were not prevented by puromycin and hence were not dependent upon the synthesis of new enzymes. They were, however, energy-dependent.</description><subject>Adenoviridae</subject><subject>Arsenic - pharmacology</subject><subject>Carbon Isotopes</subject><subject>Cell Membrane</subject><subject>Cell Nucleus</subject><subject>Colchicine - pharmacology</subject><subject>Cytoplasm</subject><subject>Dinitrophenols - pharmacology</subject><subject>HeLa Cells - drug effects</subject><subject>Microscopy, Electron</subject><subject>Nucleoproteins</subject><subject>Phagocytosis - drug effects</subject><subject>Puromycin - pharmacology</subject><subject>Viral Proteins</subject><issn>0022-538X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNot0LtOwzAYBWAPoFIKbwCSJ7YE352MqCoXqRIDF7FFifMbUiV2ajuV-vaU0ulIR0ffcBC6oSSnlBX3m12Xi1zmWutMlyqnpSrP0JwQxjLJi68LdBnjhhAqhBIzNJNcEcn0HG3fUphMmgLg2rW4hR30fhzAJewt3nVhihBxHbFvIoQdtLhzOP0Ahh5MCt7hoTPBR-NHyPFnjlcuhf3Rmpzxderc959Ut-D8kbtC57buI1yfcoE-Hlfvy-ds_fr0snxYZyNlNGVG6wZKUJYQYxXRjDHeWnOoNGkolbbgRaEIBUspUZYJwiQIzoyiDWet4Qt09--OwW8niKkaumig72sHfopVIbikQtLD8PY0nJoB2moM3VCHfXX6iP8C-bVpeQ</recordid><startdate>196911</startdate><enddate>196911</enddate><creator>Morgan, C</creator><creator>Rosenkranz, H S</creator><creator>Mednis, B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>196911</creationdate><title>Structure and development of viruses as observed in the electron microscope. 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V. Entry and uncoating of adenovirus</atitle><jtitle>Journal of virology</jtitle><addtitle>J Virol</addtitle><date>1969-11</date><risdate>1969</risdate><volume>4</volume><issue>5</issue><spage>777</spage><epage>796</epage><pages>777-796</pages><issn>0022-538X</issn><abstract>Stages in the direct penetration of adenovirus through the cell membrane are illustrated. Phagocytosis with rupture of the vacuole and release of virus into the cytoplasm may also account for entry of some particles. Uncoating by digestion within phagosomes was not observed. Rather, alteration of capsid and core occurred to virions free in the cytoplasm. Nucleoprotein released from virus close to the nucleus was transported to the nuclear matrix by a unique mechanism. These events were not prevented by puromycin and hence were not dependent upon the synthesis of new enzymes. 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| fulltext | fulltext |
| identifier | ISSN: 0022-538X |
| ispartof | Journal of virology, 1969-11, Vol.4 (5), p.777-796 |
| issn | 0022-538X |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adenoviridae Arsenic - pharmacology Carbon Isotopes Cell Membrane Cell Nucleus Colchicine - pharmacology Cytoplasm Dinitrophenols - pharmacology HeLa Cells - drug effects Microscopy, Electron Nucleoproteins Phagocytosis - drug effects Puromycin - pharmacology Viral Proteins |
| title | Structure and development of viruses as observed in the electron microscope. V. Entry and uncoating of adenovirus |
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