Lipemia retinalis: Microcirculatory changes and lipid studies in a family
A 13-year-old girl with diabetic acidosis had lipemia retinalis and massive hyperchylomicronemia ( 19.5 Gm. 100 ml. total lipids) corrected by insulin administration. Fat uptake by embryonic cells in tissue culture using the patient's lipemic serum was very marked and was maximal after heparin...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 1969-12, Vol.18 (12), p.978-985 |
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| container_end_page | 985 |
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| container_issue | 12 |
| container_start_page | 978 |
| container_title | Metabolism, clinical and experimental |
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| creator | Chazan, Bernard I. Ferguson, B.Dan Castelli, William P. Touborg, Jens N.F. Balodimos, Marios C. Rutstein, D.D. |
| description | A 13-year-old girl with diabetic acidosis had lipemia retinalis and massive hyperchylomicronemia (
19.5 Gm.
100 ml.
total lipids) corrected by insulin administration. Fat uptake by embryonic cells in tissue culture using the patient's lipemic serum was very marked and was maximal after heparin administration. Red-cell aggregation could be induced in the retinal vessels at the height of her hypertriglyceridemia while conjunctival red-cell aggregation persisted at lower levels of hyperlipemia. Whole-blood viscosity was actually subnormal during the stage of lipemia. With clearing of the hyperchylomicronemia a pre-β band appeared in the lipoprotein electrophoretic pattern of the plasma, which persisted when blood lipid levels returned to normal. The patient's father, mother and brother had pre-β bands despite normal blood lipid and insulin levels and normal glucose tolerance. The pre-β band disappeared on heparin administration. This pattern may represent a prototype of carbohydrate-induced lipemia. |
| doi_str_mv | 10.1016/0026-0495(69)90013-4 |
| format | Article |
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19.5 Gm.
100 ml.
total lipids) corrected by insulin administration. Fat uptake by embryonic cells in tissue culture using the patient's lipemic serum was very marked and was maximal after heparin administration. Red-cell aggregation could be induced in the retinal vessels at the height of her hypertriglyceridemia while conjunctival red-cell aggregation persisted at lower levels of hyperlipemia. Whole-blood viscosity was actually subnormal during the stage of lipemia. With clearing of the hyperchylomicronemia a pre-β band appeared in the lipoprotein electrophoretic pattern of the plasma, which persisted when blood lipid levels returned to normal. The patient's father, mother and brother had pre-β bands despite normal blood lipid and insulin levels and normal glucose tolerance. The pre-β band disappeared on heparin administration. This pattern may represent a prototype of carbohydrate-induced lipemia.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/0026-0495(69)90013-4</identifier><identifier>PMID: 4983064</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Blood Protein Electrophoresis ; Blood Viscosity ; Cell Aggregation ; Chylomicrons - blood ; Culture Techniques ; Diabetic Ketoacidosis - complications ; Erythrocytes ; Eye Diseases - genetics ; Female ; Heparin - therapeutic use ; Humans ; Insulin - therapeutic use ; Lipid Metabolism ; Lipids - blood ; Metabolic Diseases - blood ; Metabolic Diseases - genetics ; Retinal Vessels</subject><ispartof>Metabolism, clinical and experimental, 1969-12, Vol.18 (12), p.978-985</ispartof><rights>1969</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-7792e04c95862f638e3f9df16d5de32163b03bc49569dfb19abb7a0e7226010f3</citedby><cites>FETCH-LOGICAL-c357t-7792e04c95862f638e3f9df16d5de32163b03bc49569dfb19abb7a0e7226010f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0026049569900134$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4983064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chazan, Bernard I.</creatorcontrib><creatorcontrib>Ferguson, B.Dan</creatorcontrib><creatorcontrib>Castelli, William P.</creatorcontrib><creatorcontrib>Touborg, Jens N.F.</creatorcontrib><creatorcontrib>Balodimos, Marios C.</creatorcontrib><creatorcontrib>Rutstein, D.D.</creatorcontrib><title>Lipemia retinalis: Microcirculatory changes and lipid studies in a family</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>A 13-year-old girl with diabetic acidosis had lipemia retinalis and massive hyperchylomicronemia (
19.5 Gm.
100 ml.
total lipids) corrected by insulin administration. Fat uptake by embryonic cells in tissue culture using the patient's lipemic serum was very marked and was maximal after heparin administration. Red-cell aggregation could be induced in the retinal vessels at the height of her hypertriglyceridemia while conjunctival red-cell aggregation persisted at lower levels of hyperlipemia. Whole-blood viscosity was actually subnormal during the stage of lipemia. With clearing of the hyperchylomicronemia a pre-β band appeared in the lipoprotein electrophoretic pattern of the plasma, which persisted when blood lipid levels returned to normal. The patient's father, mother and brother had pre-β bands despite normal blood lipid and insulin levels and normal glucose tolerance. The pre-β band disappeared on heparin administration. This pattern may represent a prototype of carbohydrate-induced lipemia.</description><subject>Adolescent</subject><subject>Blood Protein Electrophoresis</subject><subject>Blood Viscosity</subject><subject>Cell Aggregation</subject><subject>Chylomicrons - blood</subject><subject>Culture Techniques</subject><subject>Diabetic Ketoacidosis - complications</subject><subject>Erythrocytes</subject><subject>Eye Diseases - genetics</subject><subject>Female</subject><subject>Heparin - therapeutic use</subject><subject>Humans</subject><subject>Insulin - therapeutic use</subject><subject>Lipid Metabolism</subject><subject>Lipids - blood</subject><subject>Metabolic Diseases - blood</subject><subject>Metabolic Diseases - genetics</subject><subject>Retinal Vessels</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P5DAMhiPECgbYfwBSTwgO3XWaNGk4ICHElzSrvbDnKE1cMOrHkLQrzb-nw4w4crLk9_Vr-2HslMMvDlz9BihUDtKUF8pcGgAucrnHFrwURV4pgH22-LIcsqOU3gBA60odsANpKgFKLtjTklbYkcsijtS7ltJV9od8HDxFP7VuHOI686-uf8GUuT5kLa0oZGmcAs0d6jOXNa6jdn3CfjSuTfhzV4_Zv_u759vHfPn34en2Zpl7Ueox19oUCNKbslJFo0SFojGh4SqUAUXBlahB1H6-Wc3tmhtX19oB6qJQwKERx-x8m7uKw_uEabQdJY9t63ocpmQrKaSujJ6Ncmucv0kpYmNXkToX15aD3RC0Gzx2g8cqYz8JWjmPne3yp7rD8DW0Qzbr11sd5yf_E0abPGHvMVBEP9ow0PcLPgCwUn8k</recordid><startdate>196912</startdate><enddate>196912</enddate><creator>Chazan, Bernard I.</creator><creator>Ferguson, B.Dan</creator><creator>Castelli, William P.</creator><creator>Touborg, Jens N.F.</creator><creator>Balodimos, Marios C.</creator><creator>Rutstein, D.D.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196912</creationdate><title>Lipemia retinalis: Microcirculatory changes and lipid studies in a family</title><author>Chazan, Bernard I. ; Ferguson, B.Dan ; Castelli, William P. ; Touborg, Jens N.F. ; Balodimos, Marios C. ; Rutstein, D.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-7792e04c95862f638e3f9df16d5de32163b03bc49569dfb19abb7a0e7226010f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Adolescent</topic><topic>Blood Protein Electrophoresis</topic><topic>Blood Viscosity</topic><topic>Cell Aggregation</topic><topic>Chylomicrons - blood</topic><topic>Culture Techniques</topic><topic>Diabetic Ketoacidosis - complications</topic><topic>Erythrocytes</topic><topic>Eye Diseases - genetics</topic><topic>Female</topic><topic>Heparin - therapeutic use</topic><topic>Humans</topic><topic>Insulin - therapeutic use</topic><topic>Lipid Metabolism</topic><topic>Lipids - blood</topic><topic>Metabolic Diseases - blood</topic><topic>Metabolic Diseases - genetics</topic><topic>Retinal Vessels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chazan, Bernard I.</creatorcontrib><creatorcontrib>Ferguson, B.Dan</creatorcontrib><creatorcontrib>Castelli, William P.</creatorcontrib><creatorcontrib>Touborg, Jens N.F.</creatorcontrib><creatorcontrib>Balodimos, Marios C.</creatorcontrib><creatorcontrib>Rutstein, D.D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chazan, Bernard I.</au><au>Ferguson, B.Dan</au><au>Castelli, William P.</au><au>Touborg, Jens N.F.</au><au>Balodimos, Marios C.</au><au>Rutstein, D.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipemia retinalis: Microcirculatory changes and lipid studies in a family</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>1969-12</date><risdate>1969</risdate><volume>18</volume><issue>12</issue><spage>978</spage><epage>985</epage><pages>978-985</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>A 13-year-old girl with diabetic acidosis had lipemia retinalis and massive hyperchylomicronemia (
19.5 Gm.
100 ml.
total lipids) corrected by insulin administration. Fat uptake by embryonic cells in tissue culture using the patient's lipemic serum was very marked and was maximal after heparin administration. Red-cell aggregation could be induced in the retinal vessels at the height of her hypertriglyceridemia while conjunctival red-cell aggregation persisted at lower levels of hyperlipemia. Whole-blood viscosity was actually subnormal during the stage of lipemia. With clearing of the hyperchylomicronemia a pre-β band appeared in the lipoprotein electrophoretic pattern of the plasma, which persisted when blood lipid levels returned to normal. The patient's father, mother and brother had pre-β bands despite normal blood lipid and insulin levels and normal glucose tolerance. The pre-β band disappeared on heparin administration. This pattern may represent a prototype of carbohydrate-induced lipemia.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>4983064</pmid><doi>10.1016/0026-0495(69)90013-4</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Metabolism, clinical and experimental, 1969-12, Vol.18 (12), p.978-985 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Blood Protein Electrophoresis Blood Viscosity Cell Aggregation Chylomicrons - blood Culture Techniques Diabetic Ketoacidosis - complications Erythrocytes Eye Diseases - genetics Female Heparin - therapeutic use Humans Insulin - therapeutic use Lipid Metabolism Lipids - blood Metabolic Diseases - blood Metabolic Diseases - genetics Retinal Vessels |
| title | Lipemia retinalis: Microcirculatory changes and lipid studies in a family |
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