Auditory function in patients with systemic lupus erythematosus
Abstract Objective Patients with systemic lupus erythematosus (SLE) may develop hearing and balance disorders as a result of the immune-mediated inner ear damage due to vasculitis or ototoxicity of drugs used in SLE treatment. The aim of the study was evaluation of the hearing organ disorders in pat...
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description | Abstract Objective Patients with systemic lupus erythematosus (SLE) may develop hearing and balance disorders as a result of the immune-mediated inner ear damage due to vasculitis or ototoxicity of drugs used in SLE treatment. The aim of the study was evaluation of the hearing organ disorders in patients with SLE with particular regard to their prevalence and relationship to duration and severity of disease. The severity was assessed from involvement of organs that resulted in poorer SLE outcome, i.e. kidneys and central nervous system (CNS), and from the presence of antibodies associated with unfavourable SLE prognosis. Methods Thirty-five unselected, consecutive patients (33 women, two men, mean age 47.8 years) with SLE diagnosed in compliance to the international diagnostic criteria of the American Rheumatism Association (1982) were enrolled into the study. The control group consisted of 30 otologically healthy persons matched to the SLE group for age and sex. Case history was recorded for all patients from questionnaire data and laryngological examinations were performed, followed by pure-tone, speech and impedance audiometry and auditory brainstem response audiometry (ABR). Results In the anamnesis 71.4% of patients reported vertigo, 62.9% headaches, 40% tinnitus, 25.7% hyperacusis, 17.1% hearing loss and 2.9% ear fullness. It was found that SLE patients had a significantly poorer mean hearing thresholds than the control group for all frequencies, except for 500; 2000 and 4000 Hz. Longer ABR latency averages were observed in the group of SLE patients compared to control. Ten patients (28.6%) developed high-frequency and symmetric sensorineural hearing loss (SNHL). Significant positive correlation between mean air-conduction hearing thresholds and SLE duration ( r = 0.46, p < 0.001) was found. After taking age into consideration, hearing acuity in SLE was related to duration of disease in younger patients. Furthermore, no relation was seen between hearing level and severity of disease. Conclusions Auditory system involvement ought to be considered as one of elements of the clinical picture of systemic lupus erythematosus while determination of its character, original or secondary, requires further research. |
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The aim of the study was evaluation of the hearing organ disorders in patients with SLE with particular regard to their prevalence and relationship to duration and severity of disease. The severity was assessed from involvement of organs that resulted in poorer SLE outcome, i.e. kidneys and central nervous system (CNS), and from the presence of antibodies associated with unfavourable SLE prognosis. Methods Thirty-five unselected, consecutive patients (33 women, two men, mean age 47.8 years) with SLE diagnosed in compliance to the international diagnostic criteria of the American Rheumatism Association (1982) were enrolled into the study. The control group consisted of 30 otologically healthy persons matched to the SLE group for age and sex. Case history was recorded for all patients from questionnaire data and laryngological examinations were performed, followed by pure-tone, speech and impedance audiometry and auditory brainstem response audiometry (ABR). Results In the anamnesis 71.4% of patients reported vertigo, 62.9% headaches, 40% tinnitus, 25.7% hyperacusis, 17.1% hearing loss and 2.9% ear fullness. It was found that SLE patients had a significantly poorer mean hearing thresholds than the control group for all frequencies, except for 500; 2000 and 4000 Hz. Longer ABR latency averages were observed in the group of SLE patients compared to control. Ten patients (28.6%) developed high-frequency and symmetric sensorineural hearing loss (SNHL). Significant positive correlation between mean air-conduction hearing thresholds and SLE duration ( r = 0.46, p < 0.001) was found. After taking age into consideration, hearing acuity in SLE was related to duration of disease in younger patients. Furthermore, no relation was seen between hearing level and severity of disease. Conclusions Auditory system involvement ought to be considered as one of elements of the clinical picture of systemic lupus erythematosus while determination of its character, original or secondary, requires further research.</description><identifier>ISSN: 0385-8146</identifier><identifier>EISSN: 1879-1476</identifier><identifier>DOI: 10.1016/j.anl.2010.04.008</identifier><identifier>PMID: 20576373</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; Audiometry, Pure-Tone ; Auditory Perception - physiology ; Auditory Threshold - physiology ; Ear ; Evoked Potentials, Auditory, Brain Stem ; Female ; Hearing Disorders - etiology ; Hearing loss ; Humans ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - physiopathology ; Male ; Middle Aged ; Otolaryngology ; Systemic lupus erythematosus</subject><ispartof>Auris, nasus, larynx, 2011-02, Vol.38 (1), p.26-32</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2010 Elsevier Ireland Ltd</rights><rights>Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-ecf3e835ff3c887ddd4aeb98eee1542fc27983358343f9a46e047bfa2d68a2593</citedby><cites>FETCH-LOGICAL-c431t-ecf3e835ff3c887ddd4aeb98eee1542fc27983358343f9a46e047bfa2d68a2593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.anl.2010.04.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20576373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maciaszczyk, Katarzyna</creatorcontrib><creatorcontrib>Durko, Tomasz</creatorcontrib><creatorcontrib>Waszczykowska, Elżbieta</creatorcontrib><creatorcontrib>Erkiert-Polguj, Anna</creatorcontrib><creatorcontrib>Pajor, Anna</creatorcontrib><title>Auditory function in patients with systemic lupus erythematosus</title><title>Auris, nasus, larynx</title><addtitle>Auris Nasus Larynx</addtitle><description>Abstract Objective Patients with systemic lupus erythematosus (SLE) may develop hearing and balance disorders as a result of the immune-mediated inner ear damage due to vasculitis or ototoxicity of drugs used in SLE treatment. The aim of the study was evaluation of the hearing organ disorders in patients with SLE with particular regard to their prevalence and relationship to duration and severity of disease. The severity was assessed from involvement of organs that resulted in poorer SLE outcome, i.e. kidneys and central nervous system (CNS), and from the presence of antibodies associated with unfavourable SLE prognosis. Methods Thirty-five unselected, consecutive patients (33 women, two men, mean age 47.8 years) with SLE diagnosed in compliance to the international diagnostic criteria of the American Rheumatism Association (1982) were enrolled into the study. The control group consisted of 30 otologically healthy persons matched to the SLE group for age and sex. Case history was recorded for all patients from questionnaire data and laryngological examinations were performed, followed by pure-tone, speech and impedance audiometry and auditory brainstem response audiometry (ABR). Results In the anamnesis 71.4% of patients reported vertigo, 62.9% headaches, 40% tinnitus, 25.7% hyperacusis, 17.1% hearing loss and 2.9% ear fullness. It was found that SLE patients had a significantly poorer mean hearing thresholds than the control group for all frequencies, except for 500; 2000 and 4000 Hz. Longer ABR latency averages were observed in the group of SLE patients compared to control. Ten patients (28.6%) developed high-frequency and symmetric sensorineural hearing loss (SNHL). Significant positive correlation between mean air-conduction hearing thresholds and SLE duration ( r = 0.46, p < 0.001) was found. After taking age into consideration, hearing acuity in SLE was related to duration of disease in younger patients. Furthermore, no relation was seen between hearing level and severity of disease. Conclusions Auditory system involvement ought to be considered as one of elements of the clinical picture of systemic lupus erythematosus while determination of its character, original or secondary, requires further research.</description><subject>Adult</subject><subject>Aged</subject><subject>Audiometry, Pure-Tone</subject><subject>Auditory Perception - physiology</subject><subject>Auditory Threshold - physiology</subject><subject>Ear</subject><subject>Evoked Potentials, Auditory, Brain Stem</subject><subject>Female</subject><subject>Hearing Disorders - etiology</subject><subject>Hearing loss</subject><subject>Humans</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Otolaryngology</subject><subject>Systemic lupus erythematosus</subject><issn>0385-8146</issn><issn>1879-1476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9r3DAQxUVpaDZpP0AuxbeevBlZsi1TaAmhTQKBHJKehVYeEW38Z6uREvztq2XTHnrIaWbgvQfze4ydcVhz4M35dm2mYV1BvkGuAdQ7tuKq7Uou2-Y9W4FQdam4bI7ZCdEWAEQrug_suIK6bfK-Yt8vUu_jHJbCpclGP0-Fn4qdiR6nSMWLj48FLRRx9LYY0i5RgWGJjziaOFOij-zImYHw0-s8Zb9-_ni4vC5v765uLi9uSysFjyVaJ1CJ2jlhlWr7vpcGN51CRF7Lytmq7ZQQtRJSuM7IBkG2G2eqvlGmqjtxyr4ccndh_p2Qoh49WRwGM-GcSCspJJcAMiv5QWnDTBTQ6V3wowmL5qD32PRWZ2x6j02D1Blb9nx-TU-bEft_jr-csuDrQYD5x2ePQZPNhCz2PqCNup_9m_Hf_nPbwU_emuEJF6TtnMKU4WmuqdKg7_e97WvjuTEu2k78ASJIkx0</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Maciaszczyk, Katarzyna</creator><creator>Durko, Tomasz</creator><creator>Waszczykowska, Elżbieta</creator><creator>Erkiert-Polguj, Anna</creator><creator>Pajor, Anna</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110201</creationdate><title>Auditory function in patients with systemic lupus erythematosus</title><author>Maciaszczyk, Katarzyna ; Durko, Tomasz ; Waszczykowska, Elżbieta ; Erkiert-Polguj, Anna ; Pajor, Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-ecf3e835ff3c887ddd4aeb98eee1542fc27983358343f9a46e047bfa2d68a2593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Audiometry, Pure-Tone</topic><topic>Auditory Perception - physiology</topic><topic>Auditory Threshold - physiology</topic><topic>Ear</topic><topic>Evoked Potentials, Auditory, Brain Stem</topic><topic>Female</topic><topic>Hearing Disorders - etiology</topic><topic>Hearing loss</topic><topic>Humans</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Otolaryngology</topic><topic>Systemic lupus erythematosus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maciaszczyk, Katarzyna</creatorcontrib><creatorcontrib>Durko, Tomasz</creatorcontrib><creatorcontrib>Waszczykowska, Elżbieta</creatorcontrib><creatorcontrib>Erkiert-Polguj, Anna</creatorcontrib><creatorcontrib>Pajor, Anna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Auris, nasus, larynx</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maciaszczyk, Katarzyna</au><au>Durko, Tomasz</au><au>Waszczykowska, Elżbieta</au><au>Erkiert-Polguj, Anna</au><au>Pajor, Anna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Auditory function in patients with systemic lupus erythematosus</atitle><jtitle>Auris, nasus, larynx</jtitle><addtitle>Auris Nasus Larynx</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>38</volume><issue>1</issue><spage>26</spage><epage>32</epage><pages>26-32</pages><issn>0385-8146</issn><eissn>1879-1476</eissn><abstract>Abstract Objective Patients with systemic lupus erythematosus (SLE) may develop hearing and balance disorders as a result of the immune-mediated inner ear damage due to vasculitis or ototoxicity of drugs used in SLE treatment. The aim of the study was evaluation of the hearing organ disorders in patients with SLE with particular regard to their prevalence and relationship to duration and severity of disease. The severity was assessed from involvement of organs that resulted in poorer SLE outcome, i.e. kidneys and central nervous system (CNS), and from the presence of antibodies associated with unfavourable SLE prognosis. Methods Thirty-five unselected, consecutive patients (33 women, two men, mean age 47.8 years) with SLE diagnosed in compliance to the international diagnostic criteria of the American Rheumatism Association (1982) were enrolled into the study. The control group consisted of 30 otologically healthy persons matched to the SLE group for age and sex. Case history was recorded for all patients from questionnaire data and laryngological examinations were performed, followed by pure-tone, speech and impedance audiometry and auditory brainstem response audiometry (ABR). Results In the anamnesis 71.4% of patients reported vertigo, 62.9% headaches, 40% tinnitus, 25.7% hyperacusis, 17.1% hearing loss and 2.9% ear fullness. It was found that SLE patients had a significantly poorer mean hearing thresholds than the control group for all frequencies, except for 500; 2000 and 4000 Hz. Longer ABR latency averages were observed in the group of SLE patients compared to control. Ten patients (28.6%) developed high-frequency and symmetric sensorineural hearing loss (SNHL). Significant positive correlation between mean air-conduction hearing thresholds and SLE duration ( r = 0.46, p < 0.001) was found. After taking age into consideration, hearing acuity in SLE was related to duration of disease in younger patients. Furthermore, no relation was seen between hearing level and severity of disease. Conclusions Auditory system involvement ought to be considered as one of elements of the clinical picture of systemic lupus erythematosus while determination of its character, original or secondary, requires further research.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>20576373</pmid><doi>10.1016/j.anl.2010.04.008</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Aged Audiometry, Pure-Tone Auditory Perception - physiology Auditory Threshold - physiology Ear Evoked Potentials, Auditory, Brain Stem Female Hearing Disorders - etiology Hearing loss Humans Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - physiopathology Male Middle Aged Otolaryngology Systemic lupus erythematosus |
title | Auditory function in patients with systemic lupus erythematosus |
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