Airway cell patterns in patients suffering from COPD and OSAS (Overlap Syndrome)
Summary Background Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are two diseases that often coexist within an individual. This coexistence is known as Overlap Syndrome (OS). Both diseases are characterized by local and systemic inflammations, but no studie...
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description | Summary Background Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are two diseases that often coexist within an individual. This coexistence is known as Overlap Syndrome (OS). Both diseases are characterized by local and systemic inflammations, but no studies to date have investigated local airway inflammation in patients suffering from Overlap Syndrome. Methods We performed a Berlin Questionnaire to evaluate the presence of the principal OSAS symptoms, a pulmonary function test, and then a nocturnal oximetry and polysomnography in 72 patients that were divided into five groups: OS ( n = 18), COPD ( n = 15), OSAS ( n = 16), 12 obese without OSAS or COPD, and one control group of 11 normal subjects. All patients underwent sputum induction and the analysis of cell patterns were evaluated in all groups. The relationship with the degree of obesity, airway obstruction and OSAS severity was also evaluated. Results The percentage of neutrophils in induced sputum was higher in OS (74.33% ± 14.8), COPD (63.33% ± 13.22) and OSAS (60.69% ± 17.6) subjects compared with control groups of obese (43.5% ± 17.49) and normal weight (32.04% ± 12.26). No difference was found among Overlap, COPD, and OSAS patients ( p = 0.56). A negative correlation was found between PaO2 and percentage of airway neutrophils ( r = −0.29, p |
doi_str_mv | 10.1016/j.rmed.2010.10.023 |
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This coexistence is known as Overlap Syndrome (OS). Both diseases are characterized by local and systemic inflammations, but no studies to date have investigated local airway inflammation in patients suffering from Overlap Syndrome. Methods We performed a Berlin Questionnaire to evaluate the presence of the principal OSAS symptoms, a pulmonary function test, and then a nocturnal oximetry and polysomnography in 72 patients that were divided into five groups: OS ( n = 18), COPD ( n = 15), OSAS ( n = 16), 12 obese without OSAS or COPD, and one control group of 11 normal subjects. All patients underwent sputum induction and the analysis of cell patterns were evaluated in all groups. The relationship with the degree of obesity, airway obstruction and OSAS severity was also evaluated. Results The percentage of neutrophils in induced sputum was higher in OS (74.33% ± 14.8), COPD (63.33% ± 13.22) and OSAS (60.69% ± 17.6) subjects compared with control groups of obese (43.5% ± 17.49) and normal weight (32.04% ± 12.26). No difference was found among Overlap, COPD, and OSAS patients ( p = 0.56). A negative correlation was found between PaO2 and percentage of airway neutrophils ( r = −0.29, p < 0.05); similarly, no correlations arose between BMI, FEV1 or ODI. Conclusion Patients suffering from Overlap Syndrome present a high percentage of neutrophils in induced sputum like patients affected by COPD or OSAS alone. Our result suggests that airway inflammations is always involved in all of these diseases, even though probably sustained by different mechanisms.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2010.10.023</identifier><identifier>PMID: 21130635</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Airway inflammation ; Airway management ; Biological and medical sciences ; Chronic obstructive pulmonary disease, asthma ; Continuous Positive Airway Pressure - methods ; COPD ; Disease ; Female ; Humans ; Hypotheses ; Hypoxia ; Laboratories ; Leukocyte Count ; Male ; Medical sciences ; Middle Aged ; Neutrophils ; Obesity ; OSAS ; Overlap Syndrome ; Pneumology ; Polysomnography - methods ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Disease, Chronic Obstructive - therapy ; Pulmonary/Respiratory ; Respiratory Function Tests - methods ; Risk Factors ; Sleep Apnea, Obstructive - diagnosis ; Sleep Apnea, Obstructive - physiopathology ; Sleep Apnea, Obstructive - therapy ; Sleep disorders ; Spirometry ; Sputum - cytology ; Statistical analysis ; Surveys and Questionnaires ; Syndrome ; Treatment Outcome</subject><ispartof>Respiratory medicine, 2011-02, Vol.105 (2), p.303-309</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-1a6af790e127594706cd6eb2c9d7061a23659fb038e452e4b7121fbdc52cf753</citedby><cites>FETCH-LOGICAL-c512t-1a6af790e127594706cd6eb2c9d7061a23659fb038e452e4b7121fbdc52cf753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rmed.2010.10.023$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23779102$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21130635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lacedonia, Donato</creatorcontrib><creatorcontrib>Salerno, Francesco G</creatorcontrib><creatorcontrib>Sabato, Roberto</creatorcontrib><creatorcontrib>Carpagnano, Giovanna E</creatorcontrib><creatorcontrib>Aliani, Maria</creatorcontrib><creatorcontrib>Palladino, Grazia P</creatorcontrib><creatorcontrib>Foschino Barbaro, Maria P</creatorcontrib><title>Airway cell patterns in patients suffering from COPD and OSAS (Overlap Syndrome)</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Summary Background Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are two diseases that often coexist within an individual. This coexistence is known as Overlap Syndrome (OS). Both diseases are characterized by local and systemic inflammations, but no studies to date have investigated local airway inflammation in patients suffering from Overlap Syndrome. Methods We performed a Berlin Questionnaire to evaluate the presence of the principal OSAS symptoms, a pulmonary function test, and then a nocturnal oximetry and polysomnography in 72 patients that were divided into five groups: OS ( n = 18), COPD ( n = 15), OSAS ( n = 16), 12 obese without OSAS or COPD, and one control group of 11 normal subjects. All patients underwent sputum induction and the analysis of cell patterns were evaluated in all groups. The relationship with the degree of obesity, airway obstruction and OSAS severity was also evaluated. Results The percentage of neutrophils in induced sputum was higher in OS (74.33% ± 14.8), COPD (63.33% ± 13.22) and OSAS (60.69% ± 17.6) subjects compared with control groups of obese (43.5% ± 17.49) and normal weight (32.04% ± 12.26). No difference was found among Overlap, COPD, and OSAS patients ( p = 0.56). A negative correlation was found between PaO2 and percentage of airway neutrophils ( r = −0.29, p < 0.05); similarly, no correlations arose between BMI, FEV1 or ODI. Conclusion Patients suffering from Overlap Syndrome present a high percentage of neutrophils in induced sputum like patients affected by COPD or OSAS alone. Our result suggests that airway inflammations is always involved in all of these diseases, even though probably sustained by different mechanisms.</description><subject>Airway inflammation</subject><subject>Airway management</subject><subject>Biological and medical sciences</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Continuous Positive Airway Pressure - methods</subject><subject>COPD</subject><subject>Disease</subject><subject>Female</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Hypoxia</subject><subject>Laboratories</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neutrophils</subject><subject>Obesity</subject><subject>OSAS</subject><subject>Overlap Syndrome</subject><subject>Pneumology</subject><subject>Polysomnography - methods</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnosis</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary Disease, Chronic Obstructive - therapy</subject><subject>Pulmonary/Respiratory</subject><subject>Respiratory Function Tests - methods</subject><subject>Risk Factors</subject><subject>Sleep Apnea, Obstructive - diagnosis</subject><subject>Sleep Apnea, Obstructive - physiopathology</subject><subject>Sleep Apnea, Obstructive - therapy</subject><subject>Sleep disorders</subject><subject>Spirometry</subject><subject>Sputum - cytology</subject><subject>Statistical analysis</subject><subject>Surveys and Questionnaires</subject><subject>Syndrome</subject><subject>Treatment Outcome</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt-LEzEQx4MoXj39B3yQgIj6sDWTH7tdEKHUn3DQg957SLMTSd1ma7J70v_exPY4uAefZpj5zK8vQ8hLYHNgUH_YzeMeuzln_wJzxsUjMgMleCVYLR-TGWuVrGoAuCDPUtoxxlop2VNywQEyItSMXC99_GOO1GLf04MZR4whUR-K7zGMiabJOYw-_KQuDnu6Wl9_piZ0dL1Zbui79S3G3hzo5hi6nMb3z8kTZ_qEL872ktx8_XKz-l5drb_9WC2vKquAjxWY2rimZQi8Ua1sWG27Grfctl32wXBRq9ZtmVigVBzltgEObttZxa1rlLgkb09tD3H4PWEa9d6ncoQJOExJL6SQIBacZ_L1A3I3TDHk3TQwoUCIWhSKnygbh5QiOn2Ifm_iMUO6qK13uqiti9olltXORa_Oradtyd2V3MmbgTdnwCRrehdNsD7dc6JpWmBl-scTh1mxW49RJ5vVt9j5iHbU3eD_v8enB-W298Hnib_wiOn-Xp24ZnpT_qK8BeSPkI1sxV-pd682</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Lacedonia, Donato</creator><creator>Salerno, Francesco G</creator><creator>Sabato, Roberto</creator><creator>Carpagnano, Giovanna E</creator><creator>Aliani, Maria</creator><creator>Palladino, Grazia P</creator><creator>Foschino Barbaro, Maria P</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20110201</creationdate><title>Airway cell patterns in patients suffering from COPD and OSAS (Overlap Syndrome)</title><author>Lacedonia, Donato ; Salerno, Francesco G ; Sabato, Roberto ; Carpagnano, Giovanna E ; Aliani, Maria ; Palladino, Grazia P ; Foschino Barbaro, Maria P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-1a6af790e127594706cd6eb2c9d7061a23659fb038e452e4b7121fbdc52cf753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Airway inflammation</topic><topic>Airway management</topic><topic>Biological and medical sciences</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Continuous Positive Airway Pressure - methods</topic><topic>COPD</topic><topic>Disease</topic><topic>Female</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Hypoxia</topic><topic>Laboratories</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neutrophils</topic><topic>Obesity</topic><topic>OSAS</topic><topic>Overlap Syndrome</topic><topic>Pneumology</topic><topic>Polysomnography - methods</topic><topic>Pulmonary Disease, Chronic Obstructive - diagnosis</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary Disease, Chronic Obstructive - therapy</topic><topic>Pulmonary/Respiratory</topic><topic>Respiratory Function Tests - methods</topic><topic>Risk Factors</topic><topic>Sleep Apnea, Obstructive - diagnosis</topic><topic>Sleep Apnea, Obstructive - physiopathology</topic><topic>Sleep Apnea, Obstructive - therapy</topic><topic>Sleep disorders</topic><topic>Spirometry</topic><topic>Sputum - cytology</topic><topic>Statistical analysis</topic><topic>Surveys and Questionnaires</topic><topic>Syndrome</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lacedonia, Donato</creatorcontrib><creatorcontrib>Salerno, Francesco G</creatorcontrib><creatorcontrib>Sabato, Roberto</creatorcontrib><creatorcontrib>Carpagnano, Giovanna E</creatorcontrib><creatorcontrib>Aliani, Maria</creatorcontrib><creatorcontrib>Palladino, Grazia P</creatorcontrib><creatorcontrib>Foschino Barbaro, Maria P</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lacedonia, Donato</au><au>Salerno, Francesco G</au><au>Sabato, Roberto</au><au>Carpagnano, Giovanna E</au><au>Aliani, Maria</au><au>Palladino, Grazia P</au><au>Foschino Barbaro, Maria P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Airway cell patterns in patients suffering from COPD and OSAS (Overlap Syndrome)</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>105</volume><issue>2</issue><spage>303</spage><epage>309</epage><pages>303-309</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Summary Background Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are two diseases that often coexist within an individual. This coexistence is known as Overlap Syndrome (OS). Both diseases are characterized by local and systemic inflammations, but no studies to date have investigated local airway inflammation in patients suffering from Overlap Syndrome. Methods We performed a Berlin Questionnaire to evaluate the presence of the principal OSAS symptoms, a pulmonary function test, and then a nocturnal oximetry and polysomnography in 72 patients that were divided into five groups: OS ( n = 18), COPD ( n = 15), OSAS ( n = 16), 12 obese without OSAS or COPD, and one control group of 11 normal subjects. All patients underwent sputum induction and the analysis of cell patterns were evaluated in all groups. The relationship with the degree of obesity, airway obstruction and OSAS severity was also evaluated. Results The percentage of neutrophils in induced sputum was higher in OS (74.33% ± 14.8), COPD (63.33% ± 13.22) and OSAS (60.69% ± 17.6) subjects compared with control groups of obese (43.5% ± 17.49) and normal weight (32.04% ± 12.26). No difference was found among Overlap, COPD, and OSAS patients ( p = 0.56). A negative correlation was found between PaO2 and percentage of airway neutrophils ( r = −0.29, p < 0.05); similarly, no correlations arose between BMI, FEV1 or ODI. Conclusion Patients suffering from Overlap Syndrome present a high percentage of neutrophils in induced sputum like patients affected by COPD or OSAS alone. Our result suggests that airway inflammations is always involved in all of these diseases, even though probably sustained by different mechanisms.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>21130635</pmid><doi>10.1016/j.rmed.2010.10.023</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Airway inflammation Airway management Biological and medical sciences Chronic obstructive pulmonary disease, asthma Continuous Positive Airway Pressure - methods COPD Disease Female Humans Hypotheses Hypoxia Laboratories Leukocyte Count Male Medical sciences Middle Aged Neutrophils Obesity OSAS Overlap Syndrome Pneumology Polysomnography - methods Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Disease, Chronic Obstructive - therapy Pulmonary/Respiratory Respiratory Function Tests - methods Risk Factors Sleep Apnea, Obstructive - diagnosis Sleep Apnea, Obstructive - physiopathology Sleep Apnea, Obstructive - therapy Sleep disorders Spirometry Sputum - cytology Statistical analysis Surveys and Questionnaires Syndrome Treatment Outcome |
title | Airway cell patterns in patients suffering from COPD and OSAS (Overlap Syndrome) |
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