Anti-inflammatory and antinociceptive effects of Garcinia brasiliensis
In Brazilian folk medicine, the leaves of Garcinia brasiliensis are used to treat tumors, inflammation of the urinary tract and arthritis as well as to relieve pain. Nevertheless, scientific information regarding Garcinia brasiliensis is limited; there are no reports related to its possible anti-inf...
Gespeichert in:
| Veröffentlicht in: | Journal of ethnopharmacology 2011-01, Vol.133 (2), p.467-473 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 473 |
|---|---|
| container_issue | 2 |
| container_start_page | 467 |
| container_title | Journal of ethnopharmacology |
| container_volume | 133 |
| creator | Santa-Cecília, Flávia V. Vilela, Fabiana C. da Rocha, Cláudia Q. Dias, Danielle F. Cavalcante, Gustavo P. Freitas, Lissara A.S. dos Santos, Marcelo H. Giusti-Paiva, Alexandre |
| description | In Brazilian folk medicine, the leaves of Garcinia brasiliensis are used to treat tumors, inflammation of the urinary tract and arthritis as well as to relieve pain. Nevertheless, scientific information regarding Garcinia brasiliensis is limited; there are no reports related to its possible anti-inflammatory and antinociceptive effects. This study employed in vivo inflammatory and nociceptive models to evaluate the scientific basis for the traditional use of Garcinia brasiliensis.
Carrageenan-induced paw edema, peritonitis and fibrovascular tissue growth induced by s.c. cotton pellet implantation were used to investigate the anti-inflammatory activity of Garcinia brasiliensis ethanolic extract (GbEE) in rats. Formalin and acetic acid-induced writhing tests were used to investigate the antinociceptive activity in mice.
GbEE at test doses of 30–300mg/kg p.o. clearly demonstrated anti-inflammatory effects by reduced paw edema induced by carrageenan, inhibited leukocyte recruitment into the peritoneal cavity, and in the model of chronic inflammation using the cotton pellet-induced fibrovascular tissue growth in rats, the GbEE significantly inhibited the formation of granulomatous tissue.
The extracts at test doses of 30–300mg/kg, p.o., clearly demonstrated antinociceptive activity, except for the first phase of the formalin test.
GbEE markedly demonstrated anti-inflammatory action in rats and antinociceptive activity in mice, which supports previous claims of the traditional use of species of the Garcinia genus for inflammation and pain. |
| doi_str_mv | 10.1016/j.jep.2010.09.036 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_843413702</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874110007130</els_id><sourcerecordid>843413702</sourcerecordid><originalsourceid>FETCH-LOGICAL-c449t-ad72a5e6326d26d1057200c7b9ca83fae74e0945be6f4ac187791d75aae327a3</originalsourceid><addsrcrecordid>eNp9kE1PGzEQhi1UBCntD-ACe0E9bTr-2LWtnhACioTUQ-nZmnjHyNF-BHuDxL_HUVJ6q2TLGul5Z8YPY-cclhx4-329XNNmKaDUYJcg2yO24EaLWjdafmILkNrURit-yj7nvAYAzRWcsFMBtmm0Fgt2dz3OsY5j6HEYcJ7SW4VjV-4cx8lHT5s5vlJFIZCfczWF6h6Tj2PEapUwxz7SmGP-wo4D9pm-Ht4z9nR3-3Tzs378df9wc_1Ye6XsXGOnBTbUStF25XBotADwemU9GhmQtCKwqllRGxT68hdteacbRJJCozxj3_ZtN2l62VKe3RCzp77HkaZtdkZJxaUGUUi-J32ack4U3CbFAdOb4-B28tzaFXluJ8-BdUVeyVwcum9XA3Ufib-2CnB1ADB77EPC0cf8j5NGGsNl4S73XMDJ4XMqzJ_fZZIEboURdkf82BNUZL1GSi77YtJTF1MR7bop_mfRd4Cjla4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>843413702</pqid></control><display><type>article</type><title>Anti-inflammatory and antinociceptive effects of Garcinia brasiliensis</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Santa-Cecília, Flávia V. ; Vilela, Fabiana C. ; da Rocha, Cláudia Q. ; Dias, Danielle F. ; Cavalcante, Gustavo P. ; Freitas, Lissara A.S. ; dos Santos, Marcelo H. ; Giusti-Paiva, Alexandre</creator><creatorcontrib>Santa-Cecília, Flávia V. ; Vilela, Fabiana C. ; da Rocha, Cláudia Q. ; Dias, Danielle F. ; Cavalcante, Gustavo P. ; Freitas, Lissara A.S. ; dos Santos, Marcelo H. ; Giusti-Paiva, Alexandre</creatorcontrib><description>In Brazilian folk medicine, the leaves of Garcinia brasiliensis are used to treat tumors, inflammation of the urinary tract and arthritis as well as to relieve pain. Nevertheless, scientific information regarding Garcinia brasiliensis is limited; there are no reports related to its possible anti-inflammatory and antinociceptive effects. This study employed in vivo inflammatory and nociceptive models to evaluate the scientific basis for the traditional use of Garcinia brasiliensis.
Carrageenan-induced paw edema, peritonitis and fibrovascular tissue growth induced by s.c. cotton pellet implantation were used to investigate the anti-inflammatory activity of Garcinia brasiliensis ethanolic extract (GbEE) in rats. Formalin and acetic acid-induced writhing tests were used to investigate the antinociceptive activity in mice.
GbEE at test doses of 30–300mg/kg p.o. clearly demonstrated anti-inflammatory effects by reduced paw edema induced by carrageenan, inhibited leukocyte recruitment into the peritoneal cavity, and in the model of chronic inflammation using the cotton pellet-induced fibrovascular tissue growth in rats, the GbEE significantly inhibited the formation of granulomatous tissue.
The extracts at test doses of 30–300mg/kg, p.o., clearly demonstrated antinociceptive activity, except for the first phase of the formalin test.
GbEE markedly demonstrated anti-inflammatory action in rats and antinociceptive activity in mice, which supports previous claims of the traditional use of species of the Garcinia genus for inflammation and pain.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2010.09.036</identifier><identifier>PMID: 20955772</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>analgesic effect ; Analgesics - isolation & purification ; Analgesics - pharmacology ; animal models ; Animals ; anti-inflammatory activity ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Bacupari ; Biological and medical sciences ; Brazil ; Clusiaceae ; dosage ; dose response ; Edema - drug therapy ; Ethnopharmacology ; Female ; Garcinia ; Garcinia - chemistry ; Garcinia - toxicity ; Garcinia brasiliensis ; General pharmacology ; granulation tissue ; herbal medicines ; Inflammation ; Male ; Medical sciences ; medicinal plants ; Medicine, Traditional ; Mice ; Nociception ; Pain ; Pain - drug therapy ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; plant extracts ; Plant Leaves - chemistry ; Plants, Medicinal - chemistry ; Plants, Medicinal - toxicity ; Rats ; Rats, Wistar</subject><ispartof>Journal of ethnopharmacology, 2011-01, Vol.133 (2), p.467-473</ispartof><rights>2010 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-ad72a5e6326d26d1057200c7b9ca83fae74e0945be6f4ac187791d75aae327a3</citedby><cites>FETCH-LOGICAL-c449t-ad72a5e6326d26d1057200c7b9ca83fae74e0945be6f4ac187791d75aae327a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2010.09.036$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23838813$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20955772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santa-Cecília, Flávia V.</creatorcontrib><creatorcontrib>Vilela, Fabiana C.</creatorcontrib><creatorcontrib>da Rocha, Cláudia Q.</creatorcontrib><creatorcontrib>Dias, Danielle F.</creatorcontrib><creatorcontrib>Cavalcante, Gustavo P.</creatorcontrib><creatorcontrib>Freitas, Lissara A.S.</creatorcontrib><creatorcontrib>dos Santos, Marcelo H.</creatorcontrib><creatorcontrib>Giusti-Paiva, Alexandre</creatorcontrib><title>Anti-inflammatory and antinociceptive effects of Garcinia brasiliensis</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>In Brazilian folk medicine, the leaves of Garcinia brasiliensis are used to treat tumors, inflammation of the urinary tract and arthritis as well as to relieve pain. Nevertheless, scientific information regarding Garcinia brasiliensis is limited; there are no reports related to its possible anti-inflammatory and antinociceptive effects. This study employed in vivo inflammatory and nociceptive models to evaluate the scientific basis for the traditional use of Garcinia brasiliensis.
Carrageenan-induced paw edema, peritonitis and fibrovascular tissue growth induced by s.c. cotton pellet implantation were used to investigate the anti-inflammatory activity of Garcinia brasiliensis ethanolic extract (GbEE) in rats. Formalin and acetic acid-induced writhing tests were used to investigate the antinociceptive activity in mice.
GbEE at test doses of 30–300mg/kg p.o. clearly demonstrated anti-inflammatory effects by reduced paw edema induced by carrageenan, inhibited leukocyte recruitment into the peritoneal cavity, and in the model of chronic inflammation using the cotton pellet-induced fibrovascular tissue growth in rats, the GbEE significantly inhibited the formation of granulomatous tissue.
The extracts at test doses of 30–300mg/kg, p.o., clearly demonstrated antinociceptive activity, except for the first phase of the formalin test.
GbEE markedly demonstrated anti-inflammatory action in rats and antinociceptive activity in mice, which supports previous claims of the traditional use of species of the Garcinia genus for inflammation and pain.</description><subject>analgesic effect</subject><subject>Analgesics - isolation & purification</subject><subject>Analgesics - pharmacology</subject><subject>animal models</subject><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Bacupari</subject><subject>Biological and medical sciences</subject><subject>Brazil</subject><subject>Clusiaceae</subject><subject>dosage</subject><subject>dose response</subject><subject>Edema - drug therapy</subject><subject>Ethnopharmacology</subject><subject>Female</subject><subject>Garcinia</subject><subject>Garcinia - chemistry</subject><subject>Garcinia - toxicity</subject><subject>Garcinia brasiliensis</subject><subject>General pharmacology</subject><subject>granulation tissue</subject><subject>herbal medicines</subject><subject>Inflammation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>Medicine, Traditional</subject><subject>Mice</subject><subject>Nociception</subject><subject>Pain</subject><subject>Pain - drug therapy</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>plant extracts</subject><subject>Plant Leaves - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><subject>Plants, Medicinal - toxicity</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PGzEQhi1UBCntD-ACe0E9bTr-2LWtnhACioTUQ-nZmnjHyNF-BHuDxL_HUVJ6q2TLGul5Z8YPY-cclhx4-329XNNmKaDUYJcg2yO24EaLWjdafmILkNrURit-yj7nvAYAzRWcsFMBtmm0Fgt2dz3OsY5j6HEYcJ7SW4VjV-4cx8lHT5s5vlJFIZCfczWF6h6Tj2PEapUwxz7SmGP-wo4D9pm-Ht4z9nR3-3Tzs378df9wc_1Ye6XsXGOnBTbUStF25XBotADwemU9GhmQtCKwqllRGxT68hdteacbRJJCozxj3_ZtN2l62VKe3RCzp77HkaZtdkZJxaUGUUi-J32ack4U3CbFAdOb4-B28tzaFXluJ8-BdUVeyVwcum9XA3Ufib-2CnB1ADB77EPC0cf8j5NGGsNl4S73XMDJ4XMqzJ_fZZIEboURdkf82BNUZL1GSi77YtJTF1MR7bop_mfRd4Cjla4</recordid><startdate>20110127</startdate><enddate>20110127</enddate><creator>Santa-Cecília, Flávia V.</creator><creator>Vilela, Fabiana C.</creator><creator>da Rocha, Cláudia Q.</creator><creator>Dias, Danielle F.</creator><creator>Cavalcante, Gustavo P.</creator><creator>Freitas, Lissara A.S.</creator><creator>dos Santos, Marcelo H.</creator><creator>Giusti-Paiva, Alexandre</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110127</creationdate><title>Anti-inflammatory and antinociceptive effects of Garcinia brasiliensis</title><author>Santa-Cecília, Flávia V. ; Vilela, Fabiana C. ; da Rocha, Cláudia Q. ; Dias, Danielle F. ; Cavalcante, Gustavo P. ; Freitas, Lissara A.S. ; dos Santos, Marcelo H. ; Giusti-Paiva, Alexandre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-ad72a5e6326d26d1057200c7b9ca83fae74e0945be6f4ac187791d75aae327a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>analgesic effect</topic><topic>Analgesics - isolation & purification</topic><topic>Analgesics - pharmacology</topic><topic>animal models</topic><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Bacupari</topic><topic>Biological and medical sciences</topic><topic>Brazil</topic><topic>Clusiaceae</topic><topic>dosage</topic><topic>dose response</topic><topic>Edema - drug therapy</topic><topic>Ethnopharmacology</topic><topic>Female</topic><topic>Garcinia</topic><topic>Garcinia - chemistry</topic><topic>Garcinia - toxicity</topic><topic>Garcinia brasiliensis</topic><topic>General pharmacology</topic><topic>granulation tissue</topic><topic>herbal medicines</topic><topic>Inflammation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>Medicine, Traditional</topic><topic>Mice</topic><topic>Nociception</topic><topic>Pain</topic><topic>Pain - drug therapy</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>plant extracts</topic><topic>Plant Leaves - chemistry</topic><topic>Plants, Medicinal - chemistry</topic><topic>Plants, Medicinal - toxicity</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santa-Cecília, Flávia V.</creatorcontrib><creatorcontrib>Vilela, Fabiana C.</creatorcontrib><creatorcontrib>da Rocha, Cláudia Q.</creatorcontrib><creatorcontrib>Dias, Danielle F.</creatorcontrib><creatorcontrib>Cavalcante, Gustavo P.</creatorcontrib><creatorcontrib>Freitas, Lissara A.S.</creatorcontrib><creatorcontrib>dos Santos, Marcelo H.</creatorcontrib><creatorcontrib>Giusti-Paiva, Alexandre</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santa-Cecília, Flávia V.</au><au>Vilela, Fabiana C.</au><au>da Rocha, Cláudia Q.</au><au>Dias, Danielle F.</au><au>Cavalcante, Gustavo P.</au><au>Freitas, Lissara A.S.</au><au>dos Santos, Marcelo H.</au><au>Giusti-Paiva, Alexandre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory and antinociceptive effects of Garcinia brasiliensis</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2011-01-27</date><risdate>2011</risdate><volume>133</volume><issue>2</issue><spage>467</spage><epage>473</epage><pages>467-473</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>In Brazilian folk medicine, the leaves of Garcinia brasiliensis are used to treat tumors, inflammation of the urinary tract and arthritis as well as to relieve pain. Nevertheless, scientific information regarding Garcinia brasiliensis is limited; there are no reports related to its possible anti-inflammatory and antinociceptive effects. This study employed in vivo inflammatory and nociceptive models to evaluate the scientific basis for the traditional use of Garcinia brasiliensis.
Carrageenan-induced paw edema, peritonitis and fibrovascular tissue growth induced by s.c. cotton pellet implantation were used to investigate the anti-inflammatory activity of Garcinia brasiliensis ethanolic extract (GbEE) in rats. Formalin and acetic acid-induced writhing tests were used to investigate the antinociceptive activity in mice.
GbEE at test doses of 30–300mg/kg p.o. clearly demonstrated anti-inflammatory effects by reduced paw edema induced by carrageenan, inhibited leukocyte recruitment into the peritoneal cavity, and in the model of chronic inflammation using the cotton pellet-induced fibrovascular tissue growth in rats, the GbEE significantly inhibited the formation of granulomatous tissue.
The extracts at test doses of 30–300mg/kg, p.o., clearly demonstrated antinociceptive activity, except for the first phase of the formalin test.
GbEE markedly demonstrated anti-inflammatory action in rats and antinociceptive activity in mice, which supports previous claims of the traditional use of species of the Garcinia genus for inflammation and pain.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>20955772</pmid><doi>10.1016/j.jep.2010.09.036</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2011-01, Vol.133 (2), p.467-473 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_843413702 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | analgesic effect Analgesics - isolation & purification Analgesics - pharmacology animal models Animals anti-inflammatory activity Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Bacupari Biological and medical sciences Brazil Clusiaceae dosage dose response Edema - drug therapy Ethnopharmacology Female Garcinia Garcinia - chemistry Garcinia - toxicity Garcinia brasiliensis General pharmacology granulation tissue herbal medicines Inflammation Male Medical sciences medicinal plants Medicine, Traditional Mice Nociception Pain Pain - drug therapy Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy plant extracts Plant Leaves - chemistry Plants, Medicinal - chemistry Plants, Medicinal - toxicity Rats Rats, Wistar |
| title | Anti-inflammatory and antinociceptive effects of Garcinia brasiliensis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T06%3A09%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anti-inflammatory%20and%20antinociceptive%20effects%20of%20Garcinia%20brasiliensis&rft.jtitle=Journal%20of%20ethnopharmacology&rft.au=Santa-Cec%C3%ADlia,%20Fl%C3%A1via%20V.&rft.date=2011-01-27&rft.volume=133&rft.issue=2&rft.spage=467&rft.epage=473&rft.pages=467-473&rft.issn=0378-8741&rft.eissn=1872-7573&rft.coden=JOETD7&rft_id=info:doi/10.1016/j.jep.2010.09.036&rft_dat=%3Cproquest_cross%3E843413702%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=843413702&rft_id=info:pmid/20955772&rft_els_id=S0378874110007130&rfr_iscdi=true |