Marek's Disease Herpesvirus: In Vivo and in vitro Infection of Kidney Cells of Different Genetic Strains of Chickens
Cell culture techniques showed kidney cells from genetically susceptible S-strain chickens exposed to JM-virus to have higher concentrations of Marek's disease (MD) herpesvirus than did those from pen-mates of the relatively resistant C-, K-, and PDRC-strains. There was quantitative correlation...
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| Veröffentlicht in: | Avian diseases 1969-11, Vol.13 (4), p.753-761 |
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| container_title | Avian diseases |
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| creator | Spencer, J. Lloyd |
| description | Cell culture techniques showed kidney cells from genetically susceptible S-strain chickens exposed to JM-virus to have higher concentrations of Marek's disease (MD) herpesvirus than did those from pen-mates of the relatively resistant C-, K-, and PDRC-strains. There was quantitative correlation between numbers of focal lesions and MD infectivity of cultures. However, factors affecting in vivo infection did not influence in vitro sensitivity. Cultured cells derived from unexposed genetically susceptible or resistant strains of chickens were equally sensitive to MD herpesvirus in vitro. The data provide circumstantial evidence that the cytopathogenic herpesvirus was the etiological agent of MD. |
| doi_str_mv | 10.2307/1588583 |
| format | Article |
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Lloyd</creator><creatorcontrib>Spencer, J. Lloyd</creatorcontrib><description>Cell culture techniques showed kidney cells from genetically susceptible S-strain chickens exposed to JM-virus to have higher concentrations of Marek's disease (MD) herpesvirus than did those from pen-mates of the relatively resistant C-, K-, and PDRC-strains. There was quantitative correlation between numbers of focal lesions and MD infectivity of cultures. However, factors affecting in vivo infection did not influence in vitro sensitivity. Cultured cells derived from unexposed genetically susceptible or resistant strains of chickens were equally sensitive to MD herpesvirus in vitro. The data provide circumstantial evidence that the cytopathogenic herpesvirus was the etiological agent of MD.</description><identifier>ISSN: 0005-2086</identifier><identifier>EISSN: 1938-4351</identifier><identifier>DOI: 10.2307/1588583</identifier><identifier>PMID: 4311861</identifier><language>eng</language><publisher>United States: American Association of Avian Pathologists, Inc</publisher><subject>Animals ; Avian Leukosis - microbiology ; Aviculture ; Cell culture techniques ; Chickens ; Culture Techniques ; Cultured cells ; Disease resistance ; Gallid herpesvirus 2 ; Herpesviridae ; Herpesviridae - isolation & purification ; Herpesviridae Infections - veterinary ; Kidney ; Kidney cells ; Lesions ; Poultry Diseases - microbiology ; Virus Cultivation ; Viruses</subject><ispartof>Avian diseases, 1969-11, Vol.13 (4), p.753-761</ispartof><rights>Copyright 1969 The American Association of Avian Pathologists, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c220t-8e0b8230b8fcdbfd9b3fc2673dd75acf38e539e3605fbad9e497491e563aad4c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1588583$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1588583$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27922,27923,58015,58248</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4311861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spencer, J. 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The data provide circumstantial evidence that the cytopathogenic herpesvirus was the etiological agent of MD.</description><subject>Animals</subject><subject>Avian Leukosis - microbiology</subject><subject>Aviculture</subject><subject>Cell culture techniques</subject><subject>Chickens</subject><subject>Culture Techniques</subject><subject>Cultured cells</subject><subject>Disease resistance</subject><subject>Gallid herpesvirus 2</subject><subject>Herpesviridae</subject><subject>Herpesviridae - isolation & purification</subject><subject>Herpesviridae Infections - veterinary</subject><subject>Kidney</subject><subject>Kidney cells</subject><subject>Lesions</subject><subject>Poultry Diseases - microbiology</subject><subject>Virus Cultivation</subject><subject>Viruses</subject><issn>0005-2086</issn><issn>1938-4351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtPwzAQhC0EKqUgfgGSD4ieAnYcJw431EJbUcSBxzVy7LVwH06x3Ur996S04sZptTufRjuD0CUltykjxR3lQnDBjlCXlkwkGeP0GHUJITxJichP0VkIM0JoUeakgzoZo1TktIvii_Qw7wc8tAFkADwGv4KwsX4d7vHE4U-7abB0GluHNzb6pj0aUNE2DjcGP1vtYIsHsFiE3T60xoAHF_EIHESr8Fv00rpfcfBl1RxcOEcnRi4CXBxmD308Pb4Pxsn0dTQZPEwTlaYkJgJILdp0tTBK10aXNTMqzQumdcGlMkwAZyWwnHBTS11CVhZZSYHnTEqdKdZDN3vflW--1xBitbRBta9KB806VCJjTOS8aMH-HlS-CcGDqVbeLqXfVpRUu36rQ78teXWwXNdL0H_codBWv97rsxAb_6_NDzRCgJo</recordid><startdate>196911</startdate><enddate>196911</enddate><creator>Spencer, J. Lloyd</creator><general>American Association of Avian Pathologists, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196911</creationdate><title>Marek's Disease Herpesvirus: In Vivo and in vitro Infection of Kidney Cells of Different Genetic Strains of Chickens</title><author>Spencer, J. Lloyd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c220t-8e0b8230b8fcdbfd9b3fc2673dd75acf38e539e3605fbad9e497491e563aad4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Animals</topic><topic>Avian Leukosis - microbiology</topic><topic>Aviculture</topic><topic>Cell culture techniques</topic><topic>Chickens</topic><topic>Culture Techniques</topic><topic>Cultured cells</topic><topic>Disease resistance</topic><topic>Gallid herpesvirus 2</topic><topic>Herpesviridae</topic><topic>Herpesviridae - isolation & purification</topic><topic>Herpesviridae Infections - veterinary</topic><topic>Kidney</topic><topic>Kidney cells</topic><topic>Lesions</topic><topic>Poultry Diseases - microbiology</topic><topic>Virus Cultivation</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spencer, J. 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Lloyd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Marek's Disease Herpesvirus: In Vivo and in vitro Infection of Kidney Cells of Different Genetic Strains of Chickens</atitle><jtitle>Avian diseases</jtitle><addtitle>Avian Dis</addtitle><date>1969-11</date><risdate>1969</risdate><volume>13</volume><issue>4</issue><spage>753</spage><epage>761</epage><pages>753-761</pages><issn>0005-2086</issn><eissn>1938-4351</eissn><abstract>Cell culture techniques showed kidney cells from genetically susceptible S-strain chickens exposed to JM-virus to have higher concentrations of Marek's disease (MD) herpesvirus than did those from pen-mates of the relatively resistant C-, K-, and PDRC-strains. There was quantitative correlation between numbers of focal lesions and MD infectivity of cultures. However, factors affecting in vivo infection did not influence in vitro sensitivity. Cultured cells derived from unexposed genetically susceptible or resistant strains of chickens were equally sensitive to MD herpesvirus in vitro. The data provide circumstantial evidence that the cytopathogenic herpesvirus was the etiological agent of MD.</abstract><cop>United States</cop><pub>American Association of Avian Pathologists, Inc</pub><pmid>4311861</pmid><doi>10.2307/1588583</doi><tpages>9</tpages></addata></record> |
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| ispartof | Avian diseases, 1969-11, Vol.13 (4), p.753-761 |
| issn | 0005-2086 1938-4351 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Animals Avian Leukosis - microbiology Aviculture Cell culture techniques Chickens Culture Techniques Cultured cells Disease resistance Gallid herpesvirus 2 Herpesviridae Herpesviridae - isolation & purification Herpesviridae Infections - veterinary Kidney Kidney cells Lesions Poultry Diseases - microbiology Virus Cultivation Viruses |
| title | Marek's Disease Herpesvirus: In Vivo and in vitro Infection of Kidney Cells of Different Genetic Strains of Chickens |
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