Alkaloids of Acronychia Baueri Schott I: Isolation of the Alkaloids and a Study of the Antitumor and Other Biological Properties of Acronycine
Utilizing a differential extraction technique for the examination of the bark of the Australian plant Acronychia Baueri Schott (Bauerella australiana Borzi), has resulted in the isolation of the triterpene lupeol and the alkaloids melicopine, acronycine, and normelicopidine. The experimental antitum...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1966-08, Vol.55 (8), p.758-768 |
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| creator | Svoboda, Gordon H. Poore, Gerald A. Simpson, Patrick J. Boder, George B. |
| description | Utilizing a differential extraction technique for the examination of the bark of the Australian plant Acronychia Baueri Schott (Bauerella australiana Borzi), has resulted in the isolation of the triterpene lupeol and the alkaloids melicopine, acronycine, and normelicopidine. The experimental antitumor activity associated with the crude alkaloidal mixture obtained from the ether extract has been shown to be attributable to acronycine. Experimental evidence is herein given, showing acronycine to have the broadest antitumor spectrum of any alkaloid isolated to date in these laboratories. By virtue of its being chemically unrelated to any of the presently utilized antitumor agents it represents a new lead in the search for agents effective in the chemotherapeutic management of human neoplasms. |
| doi_str_mv | 10.1002/jps.2600550803 |
| format | Article |
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The experimental antitumor activity associated with the crude alkaloidal mixture obtained from the ether extract has been shown to be attributable to acronycine. Experimental evidence is herein given, showing acronycine to have the broadest antitumor spectrum of any alkaloid isolated to date in these laboratories. By virtue of its being chemically unrelated to any of the presently utilized antitumor agents it represents a new lead in the search for agents effective in the chemotherapeutic management of human neoplasms.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600550803</identifier><identifier>PMID: 5975286</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Alkaloids - administration & dosage ; Alkaloids - pharmacology ; Alkaloids - therapeutic use ; Animals ; Anthracenes - pharmacology ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; Blood Protein Electrophoresis ; Carcinoma, Ehrlich Tumor - drug therapy ; Carcinoma, Squamous Cell - drug therapy ; Cell Division - drug effects ; Cerebrovascular Disorders ; Cricetinae ; Culture Techniques ; Eukaryota - drug effects ; Female ; Leukemia, Experimental - drug therapy ; Mice ; Neoplasms, Experimental - drug therapy ; Plants, Medicinal ; Rats ; Sarcoma 180 - drug therapy ; Sarcoma, Experimental - drug therapy ; Vinblastine - pharmacology</subject><ispartof>Journal of pharmaceutical sciences, 1966-08, Vol.55 (8), p.758-768</ispartof><rights>1966 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1966 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600550803$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600550803$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5975286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Svoboda, Gordon H.</creatorcontrib><creatorcontrib>Poore, Gerald A.</creatorcontrib><creatorcontrib>Simpson, Patrick J.</creatorcontrib><creatorcontrib>Boder, George B.</creatorcontrib><title>Alkaloids of Acronychia Baueri Schott I: Isolation of the Alkaloids and a Study of the Antitumor and Other Biological Properties of Acronycine</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Utilizing a differential extraction technique for the examination of the bark of the Australian plant Acronychia Baueri Schott (Bauerella australiana Borzi), has resulted in the isolation of the triterpene lupeol and the alkaloids melicopine, acronycine, and normelicopidine. The experimental antitumor activity associated with the crude alkaloidal mixture obtained from the ether extract has been shown to be attributable to acronycine. Experimental evidence is herein given, showing acronycine to have the broadest antitumor spectrum of any alkaloid isolated to date in these laboratories. By virtue of its being chemically unrelated to any of the presently utilized antitumor agents it represents a new lead in the search for agents effective in the chemotherapeutic management of human neoplasms.</description><subject>Alkaloids - administration & dosage</subject><subject>Alkaloids - pharmacology</subject><subject>Alkaloids - therapeutic use</subject><subject>Animals</subject><subject>Anthracenes - pharmacology</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Blood Protein Electrophoresis</subject><subject>Carcinoma, Ehrlich Tumor - drug therapy</subject><subject>Carcinoma, Squamous Cell - drug therapy</subject><subject>Cell Division - drug effects</subject><subject>Cerebrovascular Disorders</subject><subject>Cricetinae</subject><subject>Culture Techniques</subject><subject>Eukaryota - drug effects</subject><subject>Female</subject><subject>Leukemia, Experimental - drug therapy</subject><subject>Mice</subject><subject>Neoplasms, Experimental - drug therapy</subject><subject>Plants, Medicinal</subject><subject>Rats</subject><subject>Sarcoma 180 - drug therapy</subject><subject>Sarcoma, Experimental - drug therapy</subject><subject>Vinblastine - pharmacology</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1966</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9vEzEQxS0EKqFw5YbkE7ctXnvt9XJLAw2pKlop_DlajneWuHXWqe0t5Evwmes0UcKFkzXzfs-jmYfQ25KclYTQD7freEYFIZwTSdgzNCo5JYUgZf0cjTJAC8ar5iV6FeMtIURk8ASd8KbmVIoR-jt2d9p520bsOzw2wfcbs7Qan-sBgsVzs_Qp4dlHPIve6WR9vwXTEvDRqfsWazxPQ7s5iH2yaVj58CRe51bA59Y7_8sa7fBN8GsIycK_Y20Pr9GLTrsIb_bvKfp-8fnb5EtxdT2dTcZXBVAuWVGRyvCKU60l4125kFJA2UBr5KKBThIqWc21WHRV7urOtHlXYEJUpCYVZQ07Re93_66Dvx8gJrWy0YBzugc_RCUrRmXZ8Ay-24PDYgWtWge70mGj9gfMerPTf1sHm4NcErVNR-V01DEddXkzP1bZW-y8Nib4c_DqcKdEnRdQP79O1fTThNIf4lJtebnjIV_mwUJQ0VjoDbQ2gEmq9fY_g9kjl_ylTw</recordid><startdate>196608</startdate><enddate>196608</enddate><creator>Svoboda, Gordon H.</creator><creator>Poore, Gerald A.</creator><creator>Simpson, Patrick J.</creator><creator>Boder, George B.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>196608</creationdate><title>Alkaloids of Acronychia Baueri Schott I: Isolation of the Alkaloids and a Study of the Antitumor and Other Biological Properties of Acronycine</title><author>Svoboda, Gordon H. ; Poore, Gerald A. ; Simpson, Patrick J. ; Boder, George B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e2583-404c5452aa835f1b886e19edc8b9ef8028375a6bf419eafcd286e366407042393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1966</creationdate><topic>Alkaloids - administration & dosage</topic><topic>Alkaloids - pharmacology</topic><topic>Alkaloids - therapeutic use</topic><topic>Animals</topic><topic>Anthracenes - pharmacology</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Blood Protein Electrophoresis</topic><topic>Carcinoma, Ehrlich Tumor - drug therapy</topic><topic>Carcinoma, Squamous Cell - drug therapy</topic><topic>Cell Division - drug effects</topic><topic>Cerebrovascular Disorders</topic><topic>Cricetinae</topic><topic>Culture Techniques</topic><topic>Eukaryota - drug effects</topic><topic>Female</topic><topic>Leukemia, Experimental - drug therapy</topic><topic>Mice</topic><topic>Neoplasms, Experimental - drug therapy</topic><topic>Plants, Medicinal</topic><topic>Rats</topic><topic>Sarcoma 180 - drug therapy</topic><topic>Sarcoma, Experimental - drug therapy</topic><topic>Vinblastine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Svoboda, Gordon H.</creatorcontrib><creatorcontrib>Poore, Gerald A.</creatorcontrib><creatorcontrib>Simpson, Patrick J.</creatorcontrib><creatorcontrib>Boder, George B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Svoboda, Gordon H.</au><au>Poore, Gerald A.</au><au>Simpson, Patrick J.</au><au>Boder, George B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alkaloids of Acronychia Baueri Schott I: Isolation of the Alkaloids and a Study of the Antitumor and Other Biological Properties of Acronycine</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1966-08</date><risdate>1966</risdate><volume>55</volume><issue>8</issue><spage>758</spage><epage>768</epage><pages>758-768</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Utilizing a differential extraction technique for the examination of the bark of the Australian plant Acronychia Baueri Schott (Bauerella australiana Borzi), has resulted in the isolation of the triterpene lupeol and the alkaloids melicopine, acronycine, and normelicopidine. The experimental antitumor activity associated with the crude alkaloidal mixture obtained from the ether extract has been shown to be attributable to acronycine. Experimental evidence is herein given, showing acronycine to have the broadest antitumor spectrum of any alkaloid isolated to date in these laboratories. By virtue of its being chemically unrelated to any of the presently utilized antitumor agents it represents a new lead in the search for agents effective in the chemotherapeutic management of human neoplasms.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>5975286</pmid><doi>10.1002/jps.2600550803</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1966-08, Vol.55 (8), p.758-768 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Alkaloids - administration & dosage Alkaloids - pharmacology Alkaloids - therapeutic use Animals Anthracenes - pharmacology Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Blood Protein Electrophoresis Carcinoma, Ehrlich Tumor - drug therapy Carcinoma, Squamous Cell - drug therapy Cell Division - drug effects Cerebrovascular Disorders Cricetinae Culture Techniques Eukaryota - drug effects Female Leukemia, Experimental - drug therapy Mice Neoplasms, Experimental - drug therapy Plants, Medicinal Rats Sarcoma 180 - drug therapy Sarcoma, Experimental - drug therapy Vinblastine - pharmacology |
| title | Alkaloids of Acronychia Baueri Schott I: Isolation of the Alkaloids and a Study of the Antitumor and Other Biological Properties of Acronycine |
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