An Automated Colorimetric Method for the Determination of Meprobamate and Other N-Unsubstituted Carbamates in Pharmaceutical Products
An automated colorimetric procedure, based on the adaptation of the cobalt complex method for N-unsubstituted carbamates, has been developed for the analysis of meprobamate and other structurally related compounds in pharmaceutical products.The technique is capable of analyzing 15 samples per hour w...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1969-12, Vol.58 (12), p.1537-1539 |
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| container_end_page | 1539 |
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| container_issue | 12 |
| container_start_page | 1537 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 58 |
| creator | Cullen, L.F. Heckman, L.J. Papariello, G.J. |
| description | An automated colorimetric procedure, based on the adaptation of the cobalt complex method for N-unsubstituted carbamates, has been developed for the analysis of meprobamate and other structurally related compounds in pharmaceutical products.The technique is capable of analyzing 15 samples per hour with a relative standard deviation of 0.9% at the 400-mg.meprobamate level.Data collected on commercial formulations of a number of meprobamate combination products in addition to results on several trade packages containing structurally related therapeutic components describe the wide applicability of the method.Specificity of the procedure with respect to the analysis of intact meprobamate in the presence of its photochemical, hydrolytic, and thermal degradation products was demonstrated by comparison to quantitative thinlayer chromatography values. |
| doi_str_mv | 10.1002/jps.2600581227 |
| format | Article |
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Pharm. Sci</addtitle><description>An automated colorimetric procedure, based on the adaptation of the cobalt complex method for N-unsubstituted carbamates, has been developed for the analysis of meprobamate and other structurally related compounds in pharmaceutical products.The technique is capable of analyzing 15 samples per hour with a relative standard deviation of 0.9% at the 400-mg.meprobamate level.Data collected on commercial formulations of a number of meprobamate combination products in addition to results on several trade packages containing structurally related therapeutic components describe the wide applicability of the method.Specificity of the procedure with respect to the analysis of intact meprobamate in the presence of its photochemical, hydrolytic, and thermal degradation products was demonstrated by comparison to quantitative thinlayer chromatography values.</description><subject>analysis</subject><subject>Autoanalysis</subject><subject>automated procedure-meprobamate</subject><subject>Carbamates</subject><subject>Carbamates - analysis</subject><subject>Carbamates, N-unsubstituted, dosage forms—automated analysis</subject><subject>Carisoprodol - analysis</subject><subject>Chromatography, Thin Layer</subject><subject>Colorimetric analysis-automated spectrophotometric procedure</subject><subject>Colorimetry</subject><subject>Diagram</subject><subject>Diagram, automated procedure—meprobamate, related compounds, analysis</subject><subject>dosage forms-automated analysis</subject><subject>Meprobamate - analysis</subject><subject>Meprobamate dosage forms-automated analysis</subject><subject>Methods</subject><subject>N-unsubstituted</subject><subject>related compounds</subject><subject>Tablets - analysis</subject><subject>TLC-analysis confirmation</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFu1DAURS0EKkNhyw7JK3YZbCe2k-VogJbSaUeiFUvLsV80Lkk8tR1oP4D_xiWjIhaIlRf33Kvng9BrSpaUEPbuZh-XTBDCa8qYfIIWlDNSCELlU7TIACtKXjXP0YsYbwghgnB-hI54yUsm5QL9XI14NSU_6AQWr33vgxsgBWfwBtLOW9z5gNMO8HtIEAY36uT8iH2X833wrX5oYj1afJmpgC-K6zFObUwuTb8ndZiZiN2ItzsdBm1gSs7oHm-Dt5NJ8SV61uk-wqvDe4yuP364Wp8W55cnn9ar88JU-dqigspaWgsi25rRjmrdNA2rG21lxRklICStSVXLnJgaDOVGWt6CsJXUpZTlMXo77-bLbyeISQ0uGuh7PYKfoqqrklaC8gwuZ9AEH2OATu2zFx3uFSXqwbvK3tUf77nw5rA8tQPYR_wgOufNnP9wPdz_Z02dbb_8tV3MXRcT3D12dfimhCwlV18vTtTV5zPebDZC0czXMw9Z5XcHQUXjYDRgXQCTlPXuX9_4Bb8Usis</recordid><startdate>196912</startdate><enddate>196912</enddate><creator>Cullen, L.F.</creator><creator>Heckman, L.J.</creator><creator>Papariello, G.J.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196912</creationdate><title>An Automated Colorimetric Method for the Determination of Meprobamate and Other N-Unsubstituted Carbamates in Pharmaceutical Products</title><author>Cullen, L.F. ; Heckman, L.J. ; Papariello, G.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4277-4e4dd18607b821f1aa999289ad745210e671804871aac8ec15c7d5be6d47a3773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>analysis</topic><topic>Autoanalysis</topic><topic>automated procedure-meprobamate</topic><topic>Carbamates</topic><topic>Carbamates - analysis</topic><topic>Carbamates, N-unsubstituted, dosage forms—automated analysis</topic><topic>Carisoprodol - analysis</topic><topic>Chromatography, Thin Layer</topic><topic>Colorimetric analysis-automated spectrophotometric procedure</topic><topic>Colorimetry</topic><topic>Diagram</topic><topic>Diagram, automated procedure—meprobamate, related compounds, analysis</topic><topic>dosage forms-automated analysis</topic><topic>Meprobamate - analysis</topic><topic>Meprobamate dosage forms-automated analysis</topic><topic>Methods</topic><topic>N-unsubstituted</topic><topic>related compounds</topic><topic>Tablets - analysis</topic><topic>TLC-analysis confirmation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cullen, L.F.</creatorcontrib><creatorcontrib>Heckman, L.J.</creatorcontrib><creatorcontrib>Papariello, G.J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cullen, L.F.</au><au>Heckman, L.J.</au><au>Papariello, G.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An Automated Colorimetric Method for the Determination of Meprobamate and Other N-Unsubstituted Carbamates in Pharmaceutical Products</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1969-12</date><risdate>1969</risdate><volume>58</volume><issue>12</issue><spage>1537</spage><epage>1539</epage><pages>1537-1539</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>An automated colorimetric procedure, based on the adaptation of the cobalt complex method for N-unsubstituted carbamates, has been developed for the analysis of meprobamate and other structurally related compounds in pharmaceutical products.The technique is capable of analyzing 15 samples per hour with a relative standard deviation of 0.9% at the 400-mg.meprobamate level.Data collected on commercial formulations of a number of meprobamate combination products in addition to results on several trade packages containing structurally related therapeutic components describe the wide applicability of the method.Specificity of the procedure with respect to the analysis of intact meprobamate in the presence of its photochemical, hydrolytic, and thermal degradation products was demonstrated by comparison to quantitative thinlayer chromatography values.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>5353277</pmid><doi>10.1002/jps.2600581227</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1969-12, Vol.58 (12), p.1537-1539 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | analysis Autoanalysis automated procedure-meprobamate Carbamates Carbamates - analysis Carbamates, N-unsubstituted, dosage forms—automated analysis Carisoprodol - analysis Chromatography, Thin Layer Colorimetric analysis-automated spectrophotometric procedure Colorimetry Diagram Diagram, automated procedure—meprobamate, related compounds, analysis dosage forms-automated analysis Meprobamate - analysis Meprobamate dosage forms-automated analysis Methods N-unsubstituted related compounds Tablets - analysis TLC-analysis confirmation |
| title | An Automated Colorimetric Method for the Determination of Meprobamate and Other N-Unsubstituted Carbamates in Pharmaceutical Products |
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