Inclusion Compounds in Pharmaceutical Analysis I: Determination of Dienestrol in Dienestrol Cream
Large ratios of monostearin to dienestrol in cream formulations complicate the development of an assay for dienestrol. Monostearin was removed easily in a test-tube procedure by channel-type inclusion in urea. Dienestrol recovery was complete and reproducible analyses were obtained by polarography o...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1969-10, Vol.58 (10), p.1262-1265 |
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| container_end_page | 1265 |
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| container_issue | 10 |
| container_start_page | 1262 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 58 |
| creator | Forman, Barbara J. Grady, Lee T. |
| description | Large ratios of monostearin to dienestrol in cream formulations complicate the development of an assay for dienestrol. Monostearin was removed easily in a test-tube procedure by channel-type inclusion in urea. Dienestrol recovery was complete and reproducible analyses were obtained by polarography of the nitrosophenol derivative. Urea inclusion may offer a general approach to analytical methodology where long-chain compounds need be separated from active ingredients. |
| doi_str_mv | 10.1002/jps.2600581024 |
| format | Article |
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Monostearin was removed easily in a test-tube procedure by channel-type inclusion in urea. Dienestrol recovery was complete and reproducible analyses were obtained by polarography of the nitrosophenol derivative. Urea inclusion may offer a general approach to analytical methodology where long-chain compounds need be separated from active ingredients.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600581024</identifier><identifier>PMID: 5349117</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Chromatography ; Column chromatography-separation ; Dienestrol creams-analysis ; dienestrol creams-urea inclusion compound ; Methods ; Monostearin removal ; Monostearin removal, dienestrol creams–urea inclusion compound ; Ointments ; organic-analysis ; Phenols - analysis ; Polarography ; Polarography, organic–analysis</subject><ispartof>Journal of pharmaceutical sciences, 1969-10, Vol.58 (10), p.1262-1265</ispartof><rights>1998 Wiley Liss, Inc., A Wiley Company</rights><rights>Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4274-27b82fc58ae3806b08df8c2459a052b2b5c0bb31353c0b6a74b9ba4ee53397d3</citedby><cites>FETCH-LOGICAL-c4274-27b82fc58ae3806b08df8c2459a052b2b5c0bb31353c0b6a74b9ba4ee53397d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600581024$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600581024$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5349117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Forman, Barbara J.</creatorcontrib><creatorcontrib>Grady, Lee T.</creatorcontrib><title>Inclusion Compounds in Pharmaceutical Analysis I: Determination of Dienestrol in Dienestrol Cream</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Large ratios of monostearin to dienestrol in cream formulations complicate the development of an assay for dienestrol. Monostearin was removed easily in a test-tube procedure by channel-type inclusion in urea. Dienestrol recovery was complete and reproducible analyses were obtained by polarography of the nitrosophenol derivative. Urea inclusion may offer a general approach to analytical methodology where long-chain compounds need be separated from active ingredients.</description><subject>Chromatography</subject><subject>Column chromatography-separation</subject><subject>Dienestrol creams-analysis</subject><subject>dienestrol creams-urea inclusion compound</subject><subject>Methods</subject><subject>Monostearin removal</subject><subject>Monostearin removal, dienestrol creams–urea inclusion compound</subject><subject>Ointments</subject><subject>organic-analysis</subject><subject>Phenols - analysis</subject><subject>Polarography</subject><subject>Polarography, organic–analysis</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1969</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1DAURi0EKtPClh1SVuwyXL_yYFfN9DFVBZUYqews27kRLkk82Al0_j0eZVRggVjZ1j3fp-tDyBsKSwrA3j_s4pIVALKiwMQzsqCSQV4ALZ-TRQJYzqWoX5LTGB8AoAApT8iJ5KKmtFwQvRlsN0Xnh2zl-52fhiZmbsjuvurQa4vT6KzusvNBd_voYrb5kK1xxNC7QY-HlG-ztcMB4xh8d0j-8VoF1P0r8qLVXcTXx_OMbC8vtqvr_PbT1WZ1fptbwUqRs9JUrLWy0sgrKAxUTVtZJmStQTLDjLRgDKdc8nQpdClMbbRAlJzXZcPPyLu5dhf89yktoHoXLXadHtBPUVWC1ZLWMoHLGbTBxxiwVbvgeh32ioI6KFVJqfqtNAXeHpsn02PzhB8dpnk9z3-6Dvf_aVM3d5__6s7nrIsjPj5ldfimipKXUt1_vFLb9c09_7K9VNeJr2Yek8kfDoOKNvm22LiAdlSNd__6xi8h66US</recordid><startdate>196910</startdate><enddate>196910</enddate><creator>Forman, Barbara J.</creator><creator>Grady, Lee T.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196910</creationdate><title>Inclusion Compounds in Pharmaceutical Analysis I: Determination of Dienestrol in Dienestrol Cream</title><author>Forman, Barbara J. ; Grady, Lee T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4274-27b82fc58ae3806b08df8c2459a052b2b5c0bb31353c0b6a74b9ba4ee53397d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1969</creationdate><topic>Chromatography</topic><topic>Column chromatography-separation</topic><topic>Dienestrol creams-analysis</topic><topic>dienestrol creams-urea inclusion compound</topic><topic>Methods</topic><topic>Monostearin removal</topic><topic>Monostearin removal, dienestrol creams–urea inclusion compound</topic><topic>Ointments</topic><topic>organic-analysis</topic><topic>Phenols - analysis</topic><topic>Polarography</topic><topic>Polarography, organic–analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Forman, Barbara J.</creatorcontrib><creatorcontrib>Grady, Lee T.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forman, Barbara J.</au><au>Grady, Lee T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inclusion Compounds in Pharmaceutical Analysis I: Determination of Dienestrol in Dienestrol Cream</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. 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| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1969-10, Vol.58 (10), p.1262-1265 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Chromatography Column chromatography-separation Dienestrol creams-analysis dienestrol creams-urea inclusion compound Methods Monostearin removal Monostearin removal, dienestrol creams–urea inclusion compound Ointments organic-analysis Phenols - analysis Polarography Polarography, organic–analysis |
| title | Inclusion Compounds in Pharmaceutical Analysis I: Determination of Dienestrol in Dienestrol Cream |
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